Reactome | RPS6KA2 [cytosol]

RPS6KA2 [cytosol]

Stable Identifier

R-HSA-444252

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ribosomal protein S6 kinase alpha 2, K6A2_HUMAN, RSK3

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling (Homo sapiens)
        
        RSK activation (Homo sapiens)
        
        ERKs phosphorylate RSKs (Homo sapiens)
        
        RSK [cytosol] (Homo sapiens)
        
        RPS6KA2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15349 RPS6KA2

Gene Names

RPS6KA2, MAPKAPK1C, RSK3

Chain

chain:1-733

Reference Genes

BioGPS Gene:6196 RPS6KA2

COSMIC (genes):RPS6KA2 RPS6KA2

CTD Gene:6196 RPS6KA2

dbSNP Gene:6196 RPS6KA2

ENSEMBL:ENSG00000071242 RPS6KA2

HGNC:10431 RPS6KA2

KEGG Gene (Homo sapiens):6196 RPS6KA2

Monarch:6196 RPS6KA2

NCBI Gene:6196 RPS6KA2

OMIM:601685 RPS6KA2

UCSC:Q15349 RPS6KA2

Reference Transcript

Other Identifiers

0004280152

11731762_s_at

11731763_s_at

11743831_s_at

11756657_a_at

1557970_s_at

204906_at

212912_at

2984665

2984666

2984667

2984668

2984669

2984670

2984671

2984672

2984673

2984674

2984675

2984677

2984678

2984679

2984680

2984683

2984685

2984695

2984697

2984698

2984703

2984720

2984722

2984730

2984733

2984736

2984743

2984744

2984754

2984759

2984786

2984787

2984810

2984811

2984812

2984813

2984814

2984936

32892_at

33325_at

54736_at

6196

8130739

A_23_P335920

A_33_P3347452

A_33_P3399935

A_33_P3399943

GE82591

GE86143

GO:0000166

GO:0000287

GO:0003674

GO:0004672

GO:0004674

GO:0004711

GO:0004712

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006464

GO:0006468

GO:0007049

GO:0007165

GO:0008150

GO:0008219

GO:0008283

GO:0008285

GO:0016301

GO:0016310

GO:0016740

GO:0035556

GO:0043065

GO:0043167

GO:0043226

GO:0045786

GO:0046872

Hs.184581.0.A1_3p_at

Hs2.397210.1.S1_3p_s_at

ILMN_1702501

ILMN_1790801

PH_hs_0015556

TC06004057.hg

X85106_at

g12803118_3p_at

Participant Of

hasMember

Other forms of this molecule

RPS6KA2 [nucleoplasm]

p-4S,T356,T570-RPS6KA2 [nucleoplasm]

p-T356,S360,T570-RPS6KA2 [cytosol]

p-S218,T356,S360,S377,T570,T730-RPS6KA2 [nucleoplasm]

p-T356,S360,S377,T570,T730-RPS6KA2 [cytosol]

p-S218,T356,S360,S377,T570,T730-RPS6KA2 [cytosol]

Cross References

RefSeq

NP_066958.2, NP_001006933.2, NP_001305865.1, NP_001305866.1, NP_001305867.1

ZINC - World Drugs

KS6A2_HUMAN

OpenTargets

ENSG00000071242

ZINC - FDA approved

KS6A2_HUMAN

ZINC - Substances

KS6A2_HUMAN

ZINC target

Q15349

ZINC - Biogenic

KS6A2_HUMAN

PRO

Q15349

ZINC - Investigational

KS6A2_HUMAN

HPA

ENSG00000071242-RPS6KA2

GeneCards

Q15349

Ensembl

ENST00000503859, ENST00000265678, ENSP00000427015, ENSG00000071242, ENSP00000265678

ZINC - Predictions - Purchasable

KS6A2_HUMAN

HMDB Protein

HMDBP01159

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14160 SCRIB	1	SCRIB [cytosol] (R-HSA-4608858)	0.769	9
UniProt:P28482 MAPK1	18	MAPK1 [azurophil granule lumen] (R-HSA-6799225) MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185-MAPK1 [cytosol] (R-HSA-9635773) MAPK1 [nucleoplasm] (R-HSA-199960) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) MAPK1 [cytosol] (R-HSA-59282) p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354)	0.742	8
UniProt:P27361 MAPK3	6	p-T202-MAPK3 [cytosol] (R-HSA-9635775) MAPK3 [endoplasmic reticulum lumen] (R-HSA-9636295) p-T202,Y204-MAPK3 [nucleoplasm] (R-HSA-112359) p-T202,Y204-MAPK3 [cytosol] (R-HSA-109842) MAPK3 [cytosol] (R-HSA-59284) MAPK3 [nucleoplasm] (R-HSA-73724)	0.564	2