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RPS6KA2 [cytosol]
Stable Identifier
R-HSA-444252
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Ribosomal protein S6 kinase alpha 2, K6A2_HUMAN, RSK3
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Axon guidance (Homo sapiens)
L1CAM interactions (Homo sapiens)
Recycling pathway of L1 (Homo sapiens)
Phosphorylation of L1 by p90rsk (Homo sapiens)
p90rsk [cytosol] (Homo sapiens)
RPS6KA2 [cytosol] (Homo sapiens)
pL1 (S1152):p90rsk:clathrin-dynamin complex [endosome] (Homo sapiens)
p90rsk [cytosol] (Homo sapiens)
RPS6KA2 [cytosol] (Homo sapiens)
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling (Homo sapiens)
RSK activation (Homo sapiens)
ERKs phosphorylate RSKs (Homo sapiens)
RSK [cytosol] (Homo sapiens)
RPS6KA2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15349 RPS6KA2
Gene Names
RPS6KA2, MAPKAPK1C, RSK3
Chain
chain:1-733
Reference Genes
BioGPS Gene:6196 RPS6KA2
COSMIC (genes):RPS6KA2 RPS6KA2
CTD Gene:6196 RPS6KA2
dbSNP Gene:6196 RPS6KA2
ENSEMBL:ENSG00000071242 RPS6KA2
HGNC:10431 RPS6KA2
KEGG Gene (Homo sapiens):6196 RPS6KA2
Monarch:6196 RPS6KA2
NCBI Gene:6196 RPS6KA2
OMIM:601685 RPS6KA2
UCSC:Q15349 RPS6KA2
Reference Transcript
RefSeq:NM_001318938.1 RPS6KA2
RefSeq:NM_001318937.1 RPS6KA2
RefSeq:NM_001006932.2 RPS6KA2
RefSeq:NM_001318936.1 RPS6KA2
RefSeq:NM_021135.5 RPS6KA2
Other Identifiers
0004280152
04150+2.7.11.1
04151+2.7.11.1
04714+2.7.11.1
04926+2.7.11.1
05163+2.7.11.1
05165+2.7.11.1
05170+2.7.11.1
11731762_s_at
11731763_s_at
11743831_s_at
11756657_a_at
1557970_s_at
204906_at
212912_at
26243
2984665
2984666
2984667
2984668
2984669
2984670
2984671
2984672
2984673
2984674
2984675
2984677
2984678
2984679
2984680
2984683
2984685
2984695
2984697
2984698
2984703
2984720
2984722
2984730
2984733
2984736
2984743
2984744
2984754
2984759
2984786
2984787
2984810
2984811
2984812
2984813
2984814
2984936
32892_at
33325_at
45061
54237
54736_at
6196
69428
8130739
A_23_P335920
A_33_P3347452
A_33_P3399935
A_33_P3399943
AAC82496
AAH02363
AB209116
AK095751
AL022069
AL023775
AL159163
B7Z3B5
BAD92353
BAG53121
BC002363
CAA59427
CAB026243
CAB069428
CAI19651
CAI20579
CCDS34570
CCDS5294
D6R910
D6RA62
D6RD75
D6RE03
D6RHW7
ENSG00000071242
ENSP00000265678
ENSP00000427015
ENST00000265678
ENST00000265678.8
ENST00000503859
ENST00000503859.5
EntrezGene:6196
EntrezGene:RPS6KA2
F2Z2J1
g12803118_3p_at
GE82591
GE86143
GO:0000166
GO:0000287
GO:0003674
GO:0004672
GO:0004674
GO:0004711
GO:0004712
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006464
GO:0006468
GO:0007049
GO:0007165
GO:0008150
GO:0008219
GO:0008283
GO:0008285
GO:0016301
GO:0016310
GO:0016740
GO:0035556
GO:0043065
GO:0043167
GO:0043226
GO:0045786
GO:0046872
HGNC:10431
HPA045061
HPA054237
Hs.184581.0.A1_3p_at
Hs2.397210.1.S1_3p_s_at
ILMN_1702501
ILMN_1790801
IPR000719
IPR000961
IPR008271
IPR011009
IPR016239
IPR017441
IPR017892
IPR041906
L07598
MIM:601685
NM_001006932
NM_021135
NP_001006933
NP_066958
PF00069
PF00433
PH_hs_0015556
RPS6KA2
RPS6KA2-201
RPS6KA2-206
SM00133
SM00220
TC06004057.hg
UPI000006DAD2
UPI000020D48C
X85106
X85106_at
XM_006715549
XP_006715612
Z98049
Participant Of
hasMember
p90rsk [cytosol]
RSK [cytosol]
Other forms of this molecule
p-S218,T356,S360,S377,T570,T730-RPS6KA2 [nucleoplasm]
p-T356,S360,S377,T570,T730-RPS6KA2 [cytosol]
p-S218,T356,S360,S377,T570,T730-RPS6KA2 [cytosol]
p-T356,S360,T570-RPS6KA2 [cytosol]
p-4S,T356,T570-RPS6KA2 [nucleoplasm]
RPS6KA2 [nucleoplasm]
Cross References
ZINC - Investigational
KS6A2_HUMAN
RefSeq
NP_001305865.1
,
NP_066958.2
,
NP_001305867.1
,
NP_001006933.2
,
NP_001305866.1
ZINC - World Drugs
KS6A2_HUMAN
OpenTargets
ENSG00000071242
ZINC - FDA approved
KS6A2_HUMAN
GeneCards
Q15349
ZINC - Substances
KS6A2_HUMAN
ZINC - Biogenic
KS6A2_HUMAN
ZINC target
Q15349
PRO
Q15349
ZINC - Predictions - Purchasable
KS6A2_HUMAN
HMDB Protein
HMDBP01159
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14160 SCRIB
1
SCRIB [cytosol]
(R-HSA-4608858)
0.769
9
UniProt:P28482 MAPK1
7
MAPK1 [extracellular region]
(R-HSA-6806250)
MAPK1 [azurophil granule lumen]
(R-HSA-6799225)
MAPK1 [ficolin-1-rich granule lumen]
(R-HSA-6800964)
MAPK1 [nucleoplasm]
(R-HSA-199960)
MAPK1 [cytosol]
(R-HSA-59282)
p-T185,Y187-MAPK1 [cytosol]
(R-HSA-109853)
p-T185,Y187-MAPK1 [nucleoplasm]
(R-HSA-112354)
0.709
6
UniProt:P27361 MAPK3
4
p-T202,Y204-MAPK3 [cytosol]
(R-HSA-109842)
p-T202,Y204-MAPK3 [nucleoplasm]
(R-HSA-112359)
MAPK3 [cytosol]
(R-HSA-59284)
MAPK3 [nucleoplasm]
(R-HSA-73724)
0.564
2
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