RHAG transports NH4+ from cytosol to extracellular region (red blood cells)

Stable Identifier
R-HSA-444416
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The human gene RHAG encodes a Rhesus blood group family type A glycoprotein which is expressed specifically in erythroid cells. It is thought to mediate ammonium export from these cells (Marini et al. 2000, Westhoff et al. 2002). Defects in RHAG are the cause of regulator type Rh-null hemolytic anemia (RHN, Rh-deficiency syndrome). RHN is a form of chronic hemolytic anemia (Hyland et al. 1998).

Literature References
PubMed ID Title Journal Year
11062476 The human Rhesus-associated RhAG protein and a kidney homologue promote ammonium transport in yeast

Marini, AM, Matassi, G, Raynal, V, André, B, Cartron, JP, Chérif-Zahar, B

Nat Genet 2000
9454778 A novel single missense mutation identified along the RH50 gene in a composite heterozygous Rhnull blood donor of the regulator type

Hyland, CA, Chérif-Zahar, B, Cowley, N, Raynal, V, Parkes, J, Saul, A, Cartron, JP

Blood 1998
11861637 Identification of the erythrocyte Rh blood group glycoprotein as a mammalian ammonium transporter

Westhoff, CM, Ferreri-Jacobia, M, Mak, DO, Foskett, JK

J Biol Chem 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ammonium transmembrane transporter activity of RHAG [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created