Reactome | Cho transports from the extracellular space to the cytosol

Cho transports from the extracellular space to the cytosol

Stable Identifier

R-HSA-444433

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane, cytosol

Synonyms

CTL1-5 can mediate the uptake of choline

ReviewStatus

5/5

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Cho transports from the extracellular space to the cytosol

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Choline (Cho) transports from the extracellular space through the plasma membrane via the choline transporter-like proteins (SLC44A1-5 also known as CTL1-5) to the cytosol (Okuda & Haga 2000, Traiffort et al. 2005, O'Regan et al. 2000).

CTL1 is broadly expressed on leukocytes and endothelial cells (Wille et al. 2001). CTL2 is highly expressed in human inner ear and is the target of antibody-induced hearing loss (Nair et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
11068039	Functional characterization of the human high-affinity choline transporter Haga, T, Okuda, T	FEBS Lett	2000
11698453	Characterization of CDw92 as a member of the choline transporter-like protein family regulated specifically on dendritic cells Wille, S, Knapp, W, Prieschl, EE, Staffler, G, Stockinger, H, Stockl, J, Szekeres, A, Majdic, O, Prager, E, Burtscher, H, Kunthalert, D, Baumruker, T, Zlabinger, GJ	J Immunol	2001
15715662	Molecular characterization of the family of choline transporter-like proteins and their splice variants O'Regan, S, Meunier, FM, Ruat, M, Traiffort, E	J Neurochem	2005
10677542	An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins Compaore, D, Cha, N, O'Regan, S, Meunier, FM, Ruat, M, Traiffort, E	Proc Natl Acad Sci U S A	2000
14973250	Identification and characterization of choline transporter-like protein 2, an inner ear glycoprotein of 68 and 72 kDa that is the target of antibody-induced hearing loss Lansford, CD, Lomax, MI, Gong, TW, Carey, TE, Kozma, KE, Raphael, Y, El-Kashlan, HK, Kommareddi, PK, Berryhill, WE, Satar, B, Ueda, Y, Nair, TS, Arts, HA, Hoefling, NL, Telian, SA	J Neurosci	2004