Formyl peptide receptors bind formyl peptides and many other ligands

Stable Identifier
R-HSA-444473
Type
Pathway
Species
Homo sapiens
Compartment
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The formyl peptide receptor (FPR) was defined pharmacologically in 1976 as a high affinity binding site on the surface of neutrophils for the peptide N-formyl-methionine-leucine-phenylalanine (fMLF). FPR was cloned in 1990 and the cDNA used as a probe to identify two additional genes, FPRL1 and FPRL2. The three genes for a cluster on 19q13.3. All are coupled to the Gi family of G proteins.
All 3 receptors can be activated by formyl peptides but also display affinities for a range of structurally diverse ligands.

Literature References
PubMed ID Title Journal Year
17084101 Formyl peptide receptors: a promiscuous subfamily of G protein-coupled receptors controlling immune responses

Migeotte, I, Communi, D, Parmentier, M

Cytokine Growth Factor Rev 2006
Participants
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Orthologous Events
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