Reactome | NPS [extracellular region]

NPS [extracellular region]

Stable Identifier

R-HSA-444711

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Neuropeptide S, NPS_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Leishmania infection (Homo sapiens)
    - Leishmania parasite growth and survival (Homo sapiens)
      - Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
        
        ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)
        
        ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        NPSR1:NPS [plasma membrane] (Homo sapiens)
        
        NPS [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P0C0P6 NPS

Gene Names

NPS

Chain

signal peptide:1-23, propeptide:24-67, peptide:70-89

Reference Genes

BioGPS Gene:594857 NPS

COSMIC (genes):NPS NPS

CTD Gene:594857 NPS

dbSNP Gene:594857 NPS

ENSEMBL:ENSG00000214285 NPS

HGNC:33940 NPS

KEGG Gene (Homo sapiens):594857 NPS

Monarch:594857 NPS

NCBI Gene:594857 NPS

OMIM:609513 NPS

UCSC:P0C0P6 NPS

Reference Transcript

RefSeq:NM_001030013.1 NPS

Other Identifiers

11742672_at

16710540

3270191

3270192

3270212

594857

A_33_P3232290

GE751518

GO:0005575

GO:0005576

GO:0007165

GO:0007186

GO:0007218

GO:0007267

GO:0008150

GO:0008542

GO:0010841

GO:0032230

GO:0045760

GO:0050877

GO:0051968

ILMN_1824874

ILMN_3245281

TC10000920.hg

Participant Of

hasMember

input

Neuropeptide S receptor binds neuropeptide S

hasComponent

NPSR1:NPS [plasma membrane]

Inferred To

NPS [extracellular region] (Canis familiaris)

NPS [extracellular region] (Gallus gallus)

NPS [extracellular region] (Sus scrofa)

Nps [extracellular region] (Mus musculus)

Nps [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_001025184.1

OpenTargets

ENSG00000214285

GeneCards

P0C0P6

HPA

ENSG00000214285-NPS

Ensembl

ENSG00000214285, ENSP00000381105, ENST00000398023

PRO

P0C0P6

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