Relaxin 3 receptor 2 binds relaxin 3 and INSL5

Stable Identifier
R-HSA-444859
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Relaxin-3 receptor 2 (RXFP4 or GPR100) is activated by relaxin-3 and by INSL5. Because of overlapping expression patterns between ligand and receptor Relaxin-3 receptor 2 is considered to be a high affinity INSL5 receptor.
Literature References
PubMed ID Title Journal Year
15525639 INSL5 is a high affinity specific agonist for GPCR142 (GPR100)

Sutton, S, Kuei, C, Bathgate, R, Wilkinson, T, Bonaventure, P, Eriste, E, Sillard, R, Liu, C, Tran, DT, Lovenberg, TW, Zhu, J, Nepomuceno, D, Kamme, F, Wu, J, Chen, J

J Biol Chem 2005
14522967 Identification of relaxin-3/INSL7 as a ligand for GPCR142

Kuei, C, Roland, B, Sutton, S, Lovenberg, TW, Farmer, N, Sillard, R, Chen, J, Liu, C

J Biol Chem 2003
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