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Relaxin receptor 2 binds relaxin 2 and INSL3
Stable Identifier
R-HSA-444879
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Relaxin receptors (Homo sapiens)
Relaxin receptor 2 binds relaxin 2 and INSL3 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Relaxin receptor 2 (RXFP2 or LGR8) is activated by porcine relaxin, human relaxin-2 and insulin-like peptide-3 (INSL3). Relaxin affinity is lower than for Relaxin receptor 1, suggesting that this receptor functions as an INSL3 receptor.
Literature References
PubMed ID
Title
Journal
Year
12506116
H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2
Kumagai, J
,
Bathgate, RA
,
Ferraro, T
,
Hsueh, AJ
,
Sudo, S
,
Layfield, S
,
Nishi, S
J Biol Chem
2003
Participants
Input
RXFP2 [plasma membrane]
(Homo sapiens)
RXFP2 ligands [extracellular region]
(Homo sapiens)
Output
RXFP2:RXFP2 ligands [plasma membrane]
(Homo sapiens)
Participates
as an event of
Relaxin receptors (Homo sapiens)
Orthologous Events
Relaxin receptor 2 binds relaxin 2 and INSL3 (Bos taurus)
Relaxin receptor 2 binds relaxin 2 and INSL3 (Canis familiaris)
Relaxin receptor 2 binds relaxin 2 and INSL3 (Drosophila melanogaster)
Relaxin receptor 2 binds relaxin 2 and INSL3 (Mus musculus)
Relaxin receptor 2 binds relaxin 2 and INSL3 (Rattus norvegicus)
Relaxin receptor 2 binds relaxin 2 and INSL3 (Sus scrofa)
Authored
Jupe, S (2009-10-26)
Reviewed
D'Eustachio, P (2009-12-12)
Created
Jupe, S (2009-10-27)
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