Reactome: A Curated Pathway Database

Activation of Rac1 by VAV2

Stable Identifier
R-HSA-445064
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The small GTPase p21Rac1 is one of the important targets of VAV2 GEF activity. On L1 stimulation tyrosine phosphorylated VAV2, catalyses GDP/GTP exchange on Rac1.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
guanyl-nucleotide exchange factor activity of p-Y172-VAV2 [cytosol] p-Y172-VAV2 [cytosol] guanyl-nucleotide exchange factor activity (0005085)
Orthologous Events