L1-EGFR trans-heterodimerization

Stable Identifier
R-HSA-445069
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

L1CAM and EGFR engage in a weak heterophilic trans interaction and this induces EGFR tyrosine kinase activity and its activation. However, this trans interaction alone is not sufficient to induce EGFR autophosphorylation, which requires additional cis type interactions between the two proteins.

Literature References
PubMed ID Title Journal Year
14718570 Activation of EGF receptor kinase by L1-mediated homophilic cell interactions Mol Biol Cell 2004
Participants
Participant Of
Orthologous Events