Reactome: A Curated Pathway Database

Phosphorylation of L1 by ERK

Stable Identifier
R-HSA-445079
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

L1 cross linking can activate MAPK cascade components MEK1/2, ERK1/2, as well as Src, Raf-1,and p90rsk. MAP kinase signaling requires endocytosis mediated by Src. ERK2 can phos-phorylate internalized L1 at serine residues 1204 and 1248. This phosphorylation may increase the neurite growth.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
kinase activity of p-T185,Y187-MAPK1 [cytosol] p-T185,Y187-MAPK1 [cytosol] kinase activity (0016301)
Orthologous Events