Phosphorylation of L1 by ERK

Stable Identifier
R-HSA-445079
Type
Reaction [transition]
Species
Homo sapiens
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L1 cross linking can activate MAPK cascade components MEK1/2, ERK1/2, as well as Src, Raf-1,and p90rsk. MAP kinase signaling requires endocytosis mediated by Src. ERK2 can phos-phorylate internalized L1 at serine residues 1204 and 1248. This phosphorylation may increase the neurite growth.

Literature References
PubMed ID Title Journal Year
10608864 Activation of the MAPK signal cascade by the neural cell adhesion molecule L1 requires L1 internalization

Schaefer, AW, Kamiguchi, H, Wong, EV, Beach, CM, Landreth, G, Lemmon, V

J Biol Chem 1999
10818153 A MAP kinase-signaling pathway mediates neurite outgrowth on L1 and requires Src-dependent endocytosis

Schmid, RS, Pruitt, WM, Maness, PF

J Neurosci 2000
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Catalyst Activity
Title
MAP kinase activity of p-T185,Y187-MAPK1 [cytosol]
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Orthologous Events
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