Phosphorylation of L1 by SRC

Stable Identifier
R-HSA-445084
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Phosphorylation of L1 by SRC
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The tyrosine based sorting motif (YRSLE) in L1CD is required for clathrin mediated endocytosis. Y1176 of the YRSLE motif is phosphorylated by SRC tyrosine kinase associated with lipid rafts in the P-domain of the growth cone. Phosphorylation of Y1176 prevents L1 binding to AP-2, an adaptor required for clathrin mediated internalization of L1.

Literature References
PubMed ID Title Journal Year
12082080 L1 endocytosis is controlled by a phosphorylation-dephosphorylation cycle stimulated by outside-in signaling by L1

Schaefer, AW, Kamei, Y, Kamiguchi, H, Wong, EV, Rapoport, I, Kirchhausen, Tomas, Beach, CM, Landreth, G, Lemmon, SK, Lemmon, V

J Cell Biol 2002
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of SRC-1 [cytosol]
Physical Entity
SRC-1 [cytosol]
Activity
protein tyrosine kinase activity (0004713)
Orthologous Events
Phosphorylation of L1 by SRC (Mus musculus)
Phosphorylation of L1 by SRC (Rattus norvegicus)
Authored
Garapati, P V  (2008-07-30)
Reviewed
Maness, PF  (2010-02-16)
Created
Garapati, P V  (2009-10-27)