Reactome: A Curated Pathway Database

Phosphorylation of L1 by SRC

Stable Identifier
R-HSA-445084
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The tyrosine based sorting motif (YRSLE) in L1CD is required for clathrin mediated endocytosis. Y1176 of the YRSLE motif is phosphorylated by SRC tyrosine kinase associated with lipid rafts in the P-domain of the growth cone. Phosphorylation of Y1176 prevents L1 binding to AP-2, an adaptor required for clathrin mediated internalization of L1.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein tyrosine kinase activity of SRC-1 [cytosol] SRC-1 [cytosol] protein tyrosine kinase activity (0004713)
Orthologous Events