Reactome: A Curated Pathway Database

Dephosphorylation of pL1 (Y1176)

Stable Identifier
R-HSA-445089
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

L1 translocated to the non raft membranes of the C-domain is dephosphorylated. A number of potential candidate phosphatases exist including phosphotyrosine phosphatases. Dephosphorylation of Y1176 allows L1 binding to AP-2, an adaptor required for clathrin mediated internalization of L1.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein tyrosine phosphatase activity of unknown protein [cytosol] unknown protein [cytosol] protein tyrosine phosphatase activity (0004725)