Dephosphorylation of pL1 (Y1176)

Stable Identifier
R-HSA-445089
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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L1 translocated to the non raft membranes of the C-domain is dephosphorylated. A number of potential candidate phosphatases exist including phosphotyrosine phosphatases. Dephosphorylation of Y1176 allows L1 binding to AP-2, an adaptor required for clathrin mediated internalization of L1.

Literature References
PubMed ID Title Journal Year
12082080 L1 endocytosis is controlled by a phosphorylation-dephosphorylation cycle stimulated by outside-in signaling by L1

Schaefer, AW, Kamei, Y, Kamiguchi, H, Wong, EV, Rapoport, I, Kirchhausen, Tomas, Beach, CM, Landreth, G, Lemmon, SK, Lemmon, V

J Cell Biol 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine phosphatase activity of unknown protein [cytosol]
Physical Entity
Activity
Authored
Reviewed
Created