Reactome | Urotensin-2 receptor binds urotensin-2 and 2B

Urotensin-2 receptor binds urotensin-2 and 2B

Stable Identifier

R-HSA-445113

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Urotensin-2 receptor binds urotensin-2 and 2B

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Urotensin-II (U2) is a vasoactive 'somatostatin-like' cyclic peptide originally isolated from fish spinal cords. It was found to activate GPR14 later renamed Urotensin II receptor (U2R).
U2 is the most potent known vasoconstrictor. A second ligand for U2R, urotensin-related peptide or Urotensin 2B, was identified as an extract from rat brains, and shown to activate rat and human U2R.

Literature References

PubMed ID	Title	Journal	Year
10499587	Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14 Elshourbagy, NA, Ohlstein, EH, Aiyar, NV, Douglas, SA, Bergsma, DJ, Trill, JJ, Shabon, U, Willette, RN, Ao, Z, Coatney, RW, Martin, JD, Ellis, CE, Wilson, S, Disa, J, Hay, DW, Sarau, HM, Liu, WS, Louden, CS, Sauermelch, CF, Stadel, JM, Holmes, SD, Glover, GI, Ames, RS, Romanic, AM, McNulty, DE, Foley, JJ, Chambers, JK	Nature	1999
14550283	Identification of urotensin II-related peptide as the urotensin II-immunoreactive molecule in the rat brain Miyajima, N, Murakami, Y, Harada, M, Shimomura, Y, Fujino, M, Sugo, T, Abe, M, Suzuki, N, Kitada, C, Mori, M, Ishibashi, Y	Biochem Biophys Res Commun	2003