Reactome | SRP68 [cytosol]

SRP68 [cytosol]

Stable Identifier

R-HSA-445234

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Signal recognition particle 68 kDa protein, SRP68_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9UHB9 SRP68

Gene Names

SRP68

Chain

chain:1-627

Reference Genes

BioGPS Gene:6730 SRP68

COSMIC (genes):SRP68 SRP68

CTD Gene:6730 SRP68

dbSNP Gene:6730 SRP68

ENSEMBL:ENSG00000167881 SRP68

HGNC:11302 SRP68

KEGG:hsa:6730 SRP68

Monarch:6730 SRP68

NCBI Gene:6730 SRP68

OMIM:604858 SRP68

UCSC:Q9UHB9 SRP68

Reference Transcript

Other Identifiers

11718495_a_at

11749745_a_at

16849072

224607_PM_s_at

224607_s_at

3713447

3747386

3749200

3771298

3771299

3771300

3771301

3771302

3771303

3771304

3771305

3771306

3771307

3771308

3771309

3771310

3771312

3771313

3771314

3771315

3771317

3771318

3771319

3771320

3771321

3771322

3771323

3771324

3771326

3771327

3771328

44745_at

6730

78062_at

8018600

87378_at

A_23_P118353

GE81902

GO:0003723

GO:0005047

GO:0005515

GO:0005634

GO:0005730

GO:0005737

GO:0005783

GO:0005786

GO:0005829

GO:0005840

GO:0005925

GO:0006614

GO:0008312

GO:0009410

GO:0019904

GO:0030942

GO:0043022

GO:0048500

GO:1990904

HMNXSV003012572

Hs.273307.0.S2_3p_s_at

ILMN_1703524

PH_hs_0014103

PH_hs_0032415

TC17001892.hg

Participates

as a component of

Signal Recognition Particle [cytosol] (Homo sapiens)

Inferred To

SRP68 [cytosol] (Bos taurus)

SRP68 [cytosol] (Canis familiaris)

SRP68 [cytosol] (Gallus gallus)

SRP68 [cytosol] (Plasmodium falciparum)

SRP68 [cytosol] (Saccharomyces cerevisiae)

SRP68 [cytosol] (Sus scrofa)

Homologues of SRP68 [cytosol] (Canis familiaris)

srpa-68 [cytosol] (Caenorhabditis elegans)

Srp68 [cytosol] (Drosophila melanogaster)

Srp68 [cytosol] (Mus musculus)

Srp68 [cytosol] (Rattus norvegicus)

srp68 [cytosol] (Danio rerio)

srp68 [cytosol] (Dictyostelium discoideum)

srp68 [cytosol] (Schizosaccharomyces pombe)

srp68 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001247431.1, NP_001247432.1, NP_055045.2

OpenTargets

ENSG00000167881

ENSEMBL

ENST00000307877, ENSG00000167881, ENSP00000446136, ENSP00000473613, ENST00000539137, ENST00000602720, ENSP00000312066

HPA

ENSG00000167881-SRP68

GeneCards

SRP68

PRO

Q9UHB9

Pharos - Targets

Q9UHB9

GlyGen

Q9UHB9

PDB

5WRV, 8QVX, 4P3F, 7NFX, 7QWQ, 4P3E, 5M72, 8QVW, 5M73

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NW13 RBM28	1	RBM28 [nucleoplasm] (R-HSA-6791192)	0.527	2
UniProt:P46087 NOP2	1	NOP2 [nucleoplasm] (R-HSA-6790922)	0.527	2
UniProt:P62277 RPS13	2	RPS13 [cytosol] (R-HSA-72331) RPS13 [nucleoplasm] (R-HSA-6791198)	0.527	2
UniProt:P40429 RPL13A	2	RPL13A [cytosol] (R-HSA-72412) p-RPL13A [cytosol] (R-HSA-156829)	0.527	2
UniProt:P05388 RPLP0	1	RPLP0 [cytosol] (R-HSA-72396)	0.527	2
UniProt:P62917 RPL8	3	RPL8 [cytosol] (R-HSA-72490) RPL8 [nucleoplasm] (R-HSA-9630985) 3OHH216-RPL8 [nucleoplasm] (R-HSA-9630976)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.519	7
UniProt:P62753 RPS6	4	RPS6 [cytosol] (R-HSA-72381) p-5S-RPS6 [cytosol] (R-HSA-165727) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) RPS6 [nucleoplasm] (R-HSA-6790606)	0.483	2

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