Reactome | TWIST1 [nucleoplasm]

TWIST1 [nucleoplasm]

Stable Identifier

R-HSA-445442

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Twist-related protein 1, TWST1_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by ALK in cancer (Homo sapiens)
    - Signaling by ALK fusions and activated point mutants (Homo sapiens)
      - Nuclear events stimulated by ALK signaling in cancer (Homo sapiens)
        
        NPM1-ALK- and STAT3-dependent TWIST gene expression (Homo sapiens)
        
        TWIST1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15672 TWIST1

Gene Names

TWIST1, BHLHA38, TWIST

Chain

chain:1-202

Reference Genes

BioGPS Gene:7291 TWIST1

COSMIC (genes):TWIST1 TWIST1

CTD Gene:7291 TWIST1

dbSNP Gene:7291 TWIST1

ENSEMBL:ENSG00000122691 TWIST1

ENSEMBL_homo_sapiens_GENE:ENSG00000122691.13 TWIST1

HGNC:12428 TWIST1

KEGG Gene (Homo sapiens):7291 TWIST1

Monarch:7291 TWIST1

NCBI Gene:7291 TWIST1

OMIM:601622 TWIST1

UCSC:Q15672 TWIST1

Reference Transcript

Other Identifiers

11727666_at

213943_PM_at

213943_at

3040366

3040367

3040368

3040369

3040370

40328_at

7291

8138442

A_23_P71067

A_23_P71073

A_33_P3414591

GE60216

GO:0000122

GO:0000785

GO:0000977

GO:0000981

GO:0000987

GO:0001217

GO:0001221

GO:0001503

GO:0001649

GO:0001701

GO:0001764

GO:0001843

GO:0002376

GO:0003180

GO:0003183

GO:0003203

GO:0003253

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0006281

GO:0006351

GO:0006355

GO:0006357

GO:0006629

GO:0007517

GO:0010628

GO:0010718

GO:0010936

GO:0012501

GO:0019904

GO:0023052

GO:0030154

GO:0030326

GO:0030335

GO:0030500

GO:0032000

GO:0032502

GO:0032720

GO:0032755

GO:0032760

GO:0035115

GO:0035116

GO:0035137

GO:0035359

GO:0042473

GO:0042733

GO:0042802

GO:0042803

GO:0042826

GO:0043066

GO:0043226

GO:0043425

GO:0043518

GO:0045596

GO:0045668

GO:0045766

GO:0045843

GO:0045892

GO:0045944

GO:0046983

GO:0048511

GO:0048642

GO:0048701

GO:0048704

GO:0048856

GO:0048863

GO:0048870

GO:0050679

GO:0051898

GO:0060021

GO:0060348

GO:0060363

GO:0060900

GO:0061029

GO:0061309

GO:0070888

GO:0071363

GO:0071456

GO:0071639

GO:0097009

GO:0140110

GO:0140297

GO:1902894

GO:2000144

GO:2000147

GO:2000679

GO:2000773

GO:2000780

GO:2000793

GO:2000802

HMNXSV003041315

Hs.66744.0.S2_3p_at

ILMN_1672908

PH_hs_0004062

TC07001175.hg

Participates

as a member of

as an output of

NPM1-ALK- and STAT3-dependent TWIST gene expression (Homo sapiens)

as an input of

TWIST1 binds the RUNX2 gene promoter (Homo sapiens)

as a component of

TWIST1:RUNX2 gene [nucleoplasm] (Homo sapiens)

Inferred To

TWIST1 [nucleoplasm] (Bos taurus)

TWIST1 [nucleoplasm] (Canis familiaris)

TWIST1 [nucleoplasm] (Gallus gallus)

TWIST1 [nucleoplasm] (Sus scrofa)

Twist1 [nucleoplasm] (Mus musculus)

Twist1 [nucleoplasm] (Rattus norvegicus)

twi [nucleoplasm] (Drosophila melanogaster)

twist1b [nucleoplasm] (Danio rerio)

twist1 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

XP_011513798.1, NP_000465.1

OpenTargets

ENSG00000122691

GeneCards

Q15672

HPA

ENSG00000122691-TWIST1

Ensembl

ENST00000242261, ENSP00000242261, ENSG00000122691

PRO

Q15672

Pharos - Targets

Q15672

Orphanet

15676

PDB

2MJV, 8OSB

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P15884 TCF4	1	TCF4 [nucleoplasm] (R-HSA-445672)	0.845	9
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.817	10
UniProt:P15923-1 TCF3			0.715	6
UniProt:P62805 H4C1	17	polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) HIST1H4A [extracellular region] (R-HSA-977569) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) HIST1H4 [nucleoplasm] (R-HSA-181902)	0.662	5
UniProt:Q9NQR1 KMT5A	1	SETD8 [nucleoplasm] (R-HSA-417142)	0.632	5
UniProt:O60885 BRD4	1	BRD4 [nucleoplasm] (R-HSA-9680425)	0.623	7
UniProt:O60885-1 BRD4			0.576	9
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q12798 CETN1	7	PolyUb-Misfolded CETN1 [late endosome lumen] (R-HSA-9659982) CETN1 [cilium] (R-HSA-9639700) Misfolded CETN1 [cilium] (R-HSA-9639714) Misfolded CETN1 [cytosol] (R-HSA-9640113) Ub-Misfolded CETN1 [cytosol] (R-HSA-9641110) PolyUb-Misfolded CETN1 [cytosol] (R-HSA-9641126) PolyUb-Misfolded CETN1 [lysosomal lumen] (R-HSA-9659990)	0.527	3
UniProt:P15036 ETS2	2	p-T72-ETS2 [nucleoplasm] (R-HSA-3132735) ETS2 [nucleoplasm] (R-HSA-1629811)	0.524	2
UniProt:Q92831 KAT2B	1	KAT2B [nucleoplasm] (R-HSA-352430)	0.499	2
UniProt:P40763 STAT3	12	Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [nucleoplasm] (R-HSA-8983188) p-STAT3 [cytosol] (R-HSA-8982823) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705-STAT3 [cytosol] (R-HSA-8983130) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.488	2

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