Reactome | TCF4 [nucleoplasm]

TCF4 [nucleoplasm]

Stable Identifier

R-HSA-445672

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

E2-2/ITF-2, Transcription factor 4, ITF2_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by TGFB family members (Homo sapiens)
  - Signaling by TGFBR3 (Homo sapiens)
    - TGFBR3 expression (Homo sapiens)
      - Binding of MyoD to TGFBR3 gene promoter (Homo sapiens)
        
        MyoD:TGFBR3 gene [nucleoplasm] (Homo sapiens)
        
        Myod:phospho-E heterodimers [nucleoplasm] (Homo sapiens)
        
        phospho-E proteins [nucleoplasm] (Homo sapiens)
        
        TCF4 [nucleoplasm] (Homo sapiens)
        
        Myod:phospho-E heterodimers [nucleoplasm] (Homo sapiens)
        
        phospho-E proteins [nucleoplasm] (Homo sapiens)
        
        TCF4 [nucleoplasm] (Homo sapiens)
      - TGFBR3 transcription (Homo sapiens)
        
        MyoD:TGFBR3 gene [nucleoplasm] (Homo sapiens)
        
        Myod:phospho-E heterodimers [nucleoplasm] (Homo sapiens)
        
        phospho-E proteins [nucleoplasm] (Homo sapiens)
        
        TCF4 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P15884 TCF4

Gene Names

TCF4, BHLHB19, ITF2, SEF2

Chain

chain:1-667

Reference Genes

BioGPS Gene:6925 TCF4

COSMIC (genes):TCF4 TCF4

CTD Gene:6925 TCF4

dbSNP Gene:6925 TCF4

ENSEMBL:ENSG00000196628 TCF4

ENSEMBL_homo_sapiens_GENE:ENSG00000196628.20 TCF4

HGNC:11634 TCF4

KEGG Gene (Homo sapiens):6925 TCF4

Monarch:6925 TCF4

NCBI Gene:6925 TCF4

OMIM:602272 TCF4

UCSC:P15884 TCF4

Reference Transcript

Other Identifiers

11724239_at

11724240_at

11724241_at

11724242_s_at

11724243_at

11724244_s_at

11745765_x_at

11747698_x_at

11754605_a_at

11754733_a_at

16855382

203753_PM_at

203753_at

212382_PM_at

212382_at

212385_PM_at

212385_at

212386_PM_at

212386_at

212387_PM_at

212387_at

213891_PM_s_at

213891_s_at

222146_PM_s_at

222146_s_at

228837_PM_at

228837_at

36605_at

3808851

3808852

3808853

3808856

3808857

3808858

3808859

3808860

3808861

3808862

3808863

3808864

3808865

3808866

3808870

3808871

3808890

3808891

3808892

3808897

3808899

3808904

3808905

3808909

3808912

3808913

3808922

3808923

3808937

3808938

3808940

3808944

3808949

3808950

3808972

3808990

3808992

3808993

3808994

3808995

3808996

3808997

3808998

3808999

3809064

56847_at

6925

8023415

89997_at

A_23_P27332

GE58073

GE88135

GO:0000785

GO:0000978

GO:0000981

GO:0001093

GO:0001228

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005667

GO:0005694

GO:0006351

GO:0006355

GO:0006357

GO:0007399

GO:0008013

GO:0030154

GO:0042802

GO:0043226

GO:0045666

GO:0045893

GO:0045944

GO:0046982

GO:0046983

GO:0048856

GO:0065003

GO:0065004

GO:0070369

GO:0070888

GO:0140110

GO:1990837

GO:1990907

HMNXSV003029345

Hs.106932.0.A1_3p_at

Hs.289068.0.S1_3p_at

Hs.289068.0.S2_3p_at

Hs.289068.0.S3_3p_at

Hs.289068.0.S4_3p_a_at

Hs.289068.0.S4_3p_x_at

Hs.289068.1.S1_3p_a_at

Hs.289068.1.S1_3p_x_at

ILMN_1814194

M74719_at

PH_hs_0024014

PH_hs_0037737

TC18000527.hg

TC18000932.hg

g4507398_3p_a_at

g4507398_3p_x_at

p27308

p27309

Participates

as a candidate of

phospho-E proteins [nucleoplasm] (Homo sapiens)

Inferred To

da [nucleoplasm] (Drosophila melanogaster)

Tcf4 [nucleoplasm] (Mus musculus)

Tcf4 [nucleoplasm] (Rattus norvegicus)

hlh-2 [nucleoplasm] (Caenorhabditis elegans)

TCF4 [nucleoplasm] (Bos taurus)

TCF4 [nucleoplasm] (Canis familiaris)

TCF4 [nucleoplasm] (Gallus gallus)

TCF4 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001230165.1, NP_001335144.1, NP_001335145.1, XP_005266796.2, XP_016881429.1, XP_016881425.1, XP_006722599.1, NP_001230163.1, NP_001230157.1, NP_001335146.1, NP_001230164.1, XP_016881445.1, NP_001335147.1, NP_001077431.1, XP_006722600.1, NP_001230159.1, NP_001335140.1, NP_001230155.2, NP_001230161.1, NP_001230156.1, NP_001335148.1, NP_001335141.1, NP_001335149.1, NP_001230162.1, XP_016881430.1, XP_016881435.1, NP_001335142.1, NP_001335143.1, NP_001293136.1, NP_001293137.1, NP_001230160.1, NP_003190.1

OpenTargets

ENSG00000196628

HPA

ENSG00000196628-TCF4

GeneCards

P15884

Ensembl

ENST00000537856, ENST00000537578, ENST00000567880, ENSP00000348374, ENSP00000454647, ENST00000561992, ENSG00000196628, ENST00000561831, ENST00000543082, ENSP00000455418, ENST00000566286, ENST00000540999, ENST00000565018, ENST00000629387, ENST00000457482, ENST00000564228, ENSP00000346440, ENSP00000454366, ENSP00000439656, ENSP00000409447, ENSP00000490006, ENSP00000456125, ENSP00000455261, ENST00000568673, ENST00000564999, ENST00000616053, ENSP00000455135, ENSP00000486670, ENSP00000439827, ENST00000566279, ENST00000356073, ENSP00000486072, ENSP00000455179, ENSP00000478549, ENSP00000445202, ENSP00000455763, ENSP00000441562, ENSP00000457765, ENSP00000457649, ENST00000626584, ENSP00000455984, ENSP00000440731, ENST00000544241, ENST00000570177, ENST00000354452, ENST00000636400, ENST00000570287

PRO

P15884

Pharos - Targets

P15884

Orphanet

17229

PDB

8OSB, 6OD5, 6OD3, 2KWF, 6OD4

Interactors (47)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.94	22
UniProt:Q15672 TWIST1	1	TWIST1 [nucleoplasm] (R-HSA-445442)	0.845	9
UniProt:Q96ES7 SGF29	1	SGF29 [nucleoplasm] (R-HSA-3662279)	0.8	7
UniProt:P50553 ASCL1	1	ASCL1 [nucleoplasm] (R-HSA-212402)	0.725	8
UniProt:P47928 ID4	1	ID4 [nucleoplasm] (R-HSA-3701048)	0.725	5
UniProt:P17542 TAL1	1	TAL1 [nucleoplasm] (R-HSA-8956511)	0.689	5
UniProt:P61296 HAND2	1	HAND2 [nucleoplasm] (R-HSA-9007820)	0.666	4
UniProt:P41134 ID1	1	ID1 [nucleoplasm] (R-HSA-2534101)	0.659	4
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.564	2
UniProt:Q96AC1 FERMT2	1	FERMT2 [cytosol] (R-HSA-430275)	0.558	6
UniProt:Q13541 EIF4EBP1	2	EIF4EBP1 [cytosol] (R-HSA-72580) p-T37,T46-EIF4EBP1 [cytosol] (R-HSA-165685)	0.556	3
UniProt:Q96BZ8 LENG1	1	LENG1 [nucleoplasm] (R-HSA-9769590)	0.556	3
UniProt:P55040 GEM	1	GEM [plasma membrane] (R-HSA-9769962)	0.556	3
UniProt:P25786 PSMA1	2	PSMA1 [nucleoplasm] (R-HSA-174333) PSMA1 [cytosol] (R-HSA-68724)	0.556	3
UniProt:P38936 CDKN1A	5	p-T145-CDKN1A [cytosol] (R-HSA-198614) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) CDKN1A [cytosol] (R-HSA-182512) CDKN1A [nucleoplasm] (R-HSA-182585) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857)	0.556	3
UniProt:Q9UI95 MAD2L2	1	MAD2L2 [nucleoplasm] (R-HSA-59092)	0.556	3
UniProt:Q92888 ARHGEF1	1	ARHGEF1 [cytosol] (R-HSA-114526)	0.556	3
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.556	3
UniProt:O43559 FRS3	3	p-5Y-FRS3 [plasma membrane] (R-HSA-191475) FRS3 [plasma membrane] (R-HSA-191482) p-Y-FRS3 [plasma membrane] (R-HSA-9032427)	0.556	3
UniProt:Q969U7 PSMG2	1	PSMG2 [cytosol] (R-HSA-9908053)	0.556	3
UniProt:O60573 EIF4E2	1	EIF4E2 [cytosol] (R-HSA-1678822)	0.556	3
UniProt:Q9UIL1 SCOC	1	SCOC [cytosol] (R-HSA-6813911)	0.556	3
UniProt:O95602 POLR1A	1	POLR1A [nucleoplasm] (R-HSA-63494)	0.556	3
UniProt:Q9Y316 MEMO1	1	MEMO1 [cytosol] (R-HSA-6785630)	0.556	3
UniProt:O15160 POLR1C	2	POLR1C [nucleoplasm] (R-HSA-63498) POLR1C [cytosol] (R-HSA-1964454)	0.556	3
UniProt:Q9Y3C6 PPIL1	1	PPIL1 [nucleoplasm] (R-HSA-8867892)	0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:Q96FJ0 STAMBPL1	1	STAMBPL1 [cytosol] (R-HSA-6783264)	0.556	3
UniProt:Q9GZQ4 NMUR2	1	NMUR2 [plasma membrane] (R-HSA-964816)	0.556	3
UniProt:Q9BZE9 ASPSCR1	1	ASPSCR1 [cytoplasmic vesicle membrane] (R-HSA-1449582)	0.556	3
UniProt:Q13526 PIN1	2	PIN1 [cytosol] (R-HSA-9626823) PIN1 [nucleoplasm] (R-HSA-936016)	0.556	3
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:P54646 PRKAA2	4	PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.556	3
UniProt:Q8NFF5 FLAD1	1	FLAD1 [cytosol] (R-HSA-196980)	0.556	3
UniProt:P21281 ATP6V1B2	1	ATP6V1B2 [cytosol] (R-HSA-912598)	0.556	3
UniProt:Q5SY16 NOL9	1	NOL9 [nucleoplasm] (R-HSA-6791216)	0.556	3
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.556	3
UniProt:P17252 PRKCA	8	PRKCA [nucleoplasm] (R-HSA-450530) PRKCA [photoreceptor disc membrane] (R-HSA-2648987) PRKCA [cytosol] (R-HSA-58196) pT497,T638,S657-PRKCA [plasma membrane] (R-HSA-4332340) p-T497,T638,S657-PRKCA [cytosol] (R-HSA-4332337) PRKCA [plasma membrane] (R-HSA-156469) p-T497-PRKCA [cytosol] (R-HSA-5218731) p-T497,T638,S657-PRKCA [nucleoplasm] (R-HSA-5223292)	0.556	3
UniProt:O43929 ORC4	1	ORC4 [nucleoplasm] (R-HSA-68519)	0.556	3
UniProt:O76003 GLRX3	1	GLRX3 [cytosol] (R-HSA-5691202)	0.556	3
UniProt:Q99081 TCF12	1	TCF12 [nucleoplasm] (R-HSA-445670)	0.527	3
UniProt:Q9UPN9 TRIM33	1	TRIM33 [nucleoplasm] (R-HSA-870522)	0.527	3
UniProt:Q9Y4Z2 NEUROG3	1	NEUROG3 [nucleoplasm] (R-HSA-189530)	0.527	2
UniProt:Q13562 NEUROD1	1	NEUROD1 [nucleoplasm] (R-HSA-186689)	0.527	2
UniProt:Q0VG99 MESP2	1	MESP2 [nucleoplasm] (R-HSA-9793805)	0.527	2
UniProt:P26233 ctnnb1	1	ctnnb1 [nucleoplasm] (R-XLA-9835531)	0.499	2
UniProt:Q61473 Sox17	2	Sox17 [nucleoplasm] (R-MMU-9823740) Sox17 [nucleoplasm] (R-MMU-5625834)	0.499	5

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