ATP Hydrolysis By Myosin

Stable Identifier
R-HSA-445699
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Once ATP is bound, myosin, which is an ATPase, uses the energy from the cleavage of the terminal phosphate to pivot the myosin head back, away from the actin filamentous chain. This change in conformation "resets" the myosin molecule, leaving it ready to bind the actin filament once more and slide the myosin filament along the actin filament, continuing the contractile cycle.

Literature References
PubMed ID Title Journal Year
3780718 Isoforms of myosin and actin in human, monkey and rat myometrium. Comparison of pregnant and non-pregnant uterus proteins

Cavaillé, F, Janmot, C, Ropert, S, d'Albis, A

Eur J Biochem 1986
2526655 Characterization and differential expression of human vascular smooth muscle myosin light chain 2 isoform in nonmuscle cells

Kumar, CC, Mohan, SR, Zavodny, PJ, Narula, SK, Leibowitz, PJ

Biochemistry 1989
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
myosin phosphatase activity of ATP Bound Smooth Muscle Myosin Complex [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created