Calcium Binds Caldesmon

Stable Identifier
R-HSA-445704
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Caldesmon functions in an analogous fashion to troponin in striated muscle. Once calcium has entered the smooth muscle cell, calcium levels slowly rise. Caldesmon binds calcium, freeing tropomyosin, allowing the tropomyosin to move exposing the active sites on actin for myosin binding.

Literature References
PubMed ID Title Journal Year
1930128 The molecular anatomy of caldesmon Biochem J 1991
11457814 Invited review: cross-bridge regulation by thin filament-associated proteins J Appl Physiol 2001
Participants
Participant Of
Orthologous Events