Reactome | SORBS3 [cytosol]

SORBS3 [cytosol]

Stable Identifier

R-HSA-445805

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Vinexin, VINEX_HUMAN

Locations in the PathwayBrowser

Expand all

Muscle contraction (Homo sapiens)

- Smooth Muscle Contraction (Homo sapiens)
  - ATP Hydrolysis By Myosin (Homo sapiens)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
        
        SORBS3 [cytosol] (Homo sapiens)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
        
        SORBS3 [cytosol] (Homo sapiens)
  - Calcium Binds Caldesmon (Homo sapiens)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
        
        SORBS3 [cytosol] (Homo sapiens)
    - Inactive Myosin Actin Contractile Complex [plasma membrane] (Homo sapiens)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
        
        SORBS3 [cytosol] (Homo sapiens)
  - Myosin Binds ATP (Homo sapiens)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
        
        SORBS3 [cytosol] (Homo sapiens)
    - p-S CALD1-Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
        
        SORBS3 [cytosol] (Homo sapiens)
  - Release Of ADP From Myosin (Homo sapiens)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
        
        SORBS3 [cytosol] (Homo sapiens)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
        
        SORBS3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60504 SORBS3

Gene Names

SORBS3, SCAM1

Chain

chain:1-671, initiator methionine:1

Reference Genes

BioGPS Gene:10174 SORBS3

COSMIC (genes):SORBS3 SORBS3

CTD Gene:10174 SORBS3

dbSNP Gene:10174 SORBS3

ENSEMBL:ENSG00000120896 SORBS3

HGNC:30907 SORBS3

KEGG:hsa:10174 SORBS3

Monarch:10174 SORBS3

NCBI Gene:10174 SORBS3

OMIM:610795 SORBS3

UCSC:O60504 SORBS3

Reference Transcript

Participates

as a component of

integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)

Inferred To

CAP [cytosol] (Drosophila melanogaster)

SORBS3 [cytosol] (Bos taurus)

SORBS3 [cytosol] (Canis familiaris)

SORBS3 [cytosol] (Sus scrofa)

Sorbs3 [cytosol] (Mus musculus)

Sorbs3 [cytosol] (Rattus norvegicus)

sorbs3 [cytosol] (Xenopus tropicalis)

sorb-1 [cytosol] (Caenorhabditis elegans)

LOC107050638 [cytosol] (Gallus gallus)

Cross References

RefSeq

NP_005766.3, XP_005273428.1, NP_001018003.1, XP_016868433.1, XP_047277175.1, XP_016868434.1, XP_016868435.1

OpenTargets

ENSG00000120896

ENSEMBL

ENSP00000429764, ENSG00000120896, ENST00000523965, ENST00000240123, ENSP00000240123

HPA

ENSG00000120896-SORBS3

GeneCards

SORBS3

PRO

O60504

Pharos - Targets

O60504

GlyGen

O60504

PDB

2YUP, 2NWM, 2DLM, 2CT3

HMDB Protein

HMDBP01932

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13177 PAK2	11	p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) PAK2(1-524) [plasma membrane] (R-HSA-164946) p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524)	0.775	6
UniProt:P61978 HNRNPK	2	HNRNPK [nucleoplasm] (R-HSA-71945) polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532)	0.666	4
UniProt:P52597 HNRNPF	2	HNRNPF [nucleoplasm] (R-HSA-71937) HNRNPF [plasma membrane] (R-HSA-8950714)	0.556	3
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.556	3
UniProt:P55040 GEM	1	GEM [plasma membrane] (R-HSA-9769962)	0.556	3
UniProt:Q92917 GPKOW	1	GPKOW [nucleoplasm] (R-HSA-8850839)	0.556	3
UniProt:O75604 USP2	2	USP2 [cytosol] (R-HSA-5212661) USP2 [nucleoplasm] (R-HSA-5689946)	0.556	3
UniProt:Q15561 TEAD4	1	TEAD4 [nucleoplasm] (R-HSA-2032780)	0.556	3
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.556	3
UniProt:P31751 AKT2	7	p-T309,S474-AKT2 [nucleoplasm] (R-HSA-202087) p-T309,S474-AKT2 [cytosol] (R-HSA-202062) p-S474-AKT2 [plasma membrane] (R-HSA-2317312) AKT2 [plasma membrane] (R-HSA-202053) AKT2 [cytosol] (R-HSA-49859) p-T309-AKT2 [cytosol] (R-HSA-202066) p-T309,S474-AKT2 [plasma membrane] (R-HSA-202056)	0.556	3
UniProt:P47897 QARS1	2	QARS [cytosol] (R-HSA-379615) QARS [mitochondrial matrix] (R-HSA-379592)	0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.556	3
UniProt:P40222 TXLNA	1	TXLNA [cytosol] (R-HSA-449124)	0.556	3
UniProt:Q15742 NAB2	1	NAB2 [nucleoplasm] (R-HSA-9612177)	0.556	3
UniProt:O15160 POLR1C	2	POLR1C [cytosol] (R-HSA-1964454) POLR1C [nucleoplasm] (R-HSA-63498)	0.556	3
UniProt:Q5ST30 VARS2	1	VARS2 [mitochondrial matrix] (R-HSA-379626)	0.556	3
UniProt:O75771 RAD51D	1	RAD51D [nucleoplasm] (R-HSA-216920)	0.556	3
UniProt:Q96P48 ARAP1	2	ARAP1 [cytosol] (R-HSA-3211582) p-Y231-ARAP1 [cytosol] (R-HSA-8848869)	0.527	2
UniProt:P42684 ABL2	1	ABL2 [cytosol] (R-HSA-375998)	0.527	2
UniProt:Q9BST9 RTKN	1	RTKN [cytosol] (R-HSA-5666184)	0.508	3

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