Phosphorylation of Smooth Muscle Myosin Light Chains

Stable Identifier
R-HSA-445813
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The smooth muscle light chain kinase phosphorylates the smooth muscle light chains. This phosphorylation activates the myosin lights chains, effectively allowing contraction to begin.

Literature References
PubMed ID Title Journal Year
3780718 Isoforms of myosin and actin in human, monkey and rat myometrium. Comparison of pregnant and non-pregnant uterus proteins

Cavaillé, F, Janmot, C, Ropert, S, d'Albis, A

Eur J Biochem 1986
2526655 Characterization and differential expression of human vascular smooth muscle myosin light chain 2 isoform in nonmuscle cells

Kumar, CC, Mohan, SR, Zavodny, PJ, Narula, SK, Leibowitz, PJ

Biochemistry 1989
2764880 The distribution of heavy-chain isoforms of myosin in airways smooth muscle from adult and neonate humans

Mohammad, MA, Sparrow, MP

Biochem J 1989
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
myosin light chain kinase activity of MYLK:Ca2+:CALM1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed