TAK1 activates NFkB by phosphorylation and activation of IKKs complex

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R-HSA-445989
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Pathway
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Homo sapiens
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NF-kappaB is sequestered in the cytoplasm in a complex with inhibitor of NF-kappaB (IkB). Almost all NF-kappaB activation pathways are mediated by IkB kinase (IKK), which phosphorylates IkB resulting in dissociation of NF-kappaB from the complex. This allows translocation of NF-kappaB to the nucleus where it regulates gene expression.

Literature References
PubMed ID Title Journal Year
15837794 Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes

Thiefes, A, Wolter, S, Mushinski, JF, Hoffmann, E, Dittrich-Breiholz, O, Graue, N, Dörrie, A, Schneider, H, Wirth, D, Luckow, B, Resch, K, Kracht, M

J Biol Chem 2005
11460167 TAK1 is a ubiquitin-dependent kinase of MKK and IKK

Wang, C, Deng, L, Hong, M, Akkaraju, GR, Inoue, J, Chen, ZJ

Nature 2001
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