Reactome | RARA [nucleoplasm]

RARA [nucleoplasm]

Stable Identifier

R-HSA-446164

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Retinoic acid receptor alpha, RARA_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:P51946 CCNH

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of intracellular receptors (Homo sapiens)
        
        SUMOylation of RARA with SUMO2 (Homo sapiens)
        
        RARA [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P10276 RARA

Gene Names

RARA, NR1B1

Chain

chain:1-462

Reference Genes

BioGPS Gene:5914 RARA

COSMIC (genes):RARA RARA

CTD Gene:5914 RARA

dbSNP Gene:5914 RARA

ENSEMBL:ENSG00000131759 RARA

HGNC:9864 RARA

KEGG:hsa:5914 RARA

Monarch:5914 RARA

NCBI Gene:5914 RARA

OMIM:180240 RARA

UCSC:P10276 RARA

Reference Transcript

Participates

as an input of

SUMOylation of RARA with SUMO2 (Homo sapiens)

as a component of

as a member of

Other forms of this molecule

polySUMO2-K166,K171,K399-RARA [nucleoplasm]

SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm]

Inferred To

RARA [nucleoplasm] (Bos taurus)

RARA [nucleoplasm] (Canis familiaris)

RARA [nucleoplasm] (Gallus gallus)

RARA [nucleoplasm] (Sus scrofa)

nhr-2 [nucleoplasm] (Caenorhabditis elegans)

Rara [nucleoplasm] (Mus musculus)

Rara [nucleoplasm] (Rattus norvegicus)

Eip75B [nucleoplasm] (Drosophila melanogaster)

Homologues of RARA [nucleoplasm] (Caenorhabditis elegans)

nhr-7 [nucleoplasm] (Caenorhabditis elegans)

nhr-85 [nucleoplasm] (Caenorhabditis elegans)

sex-1 [nucleoplasm] (Caenorhabditis elegans)

raraa [nucleoplasm] (Danio rerio)

unc-55 [nucleoplasm] (Caenorhabditis elegans)

Cross References

Guide to Pharmacology - Targets

590

OpenTargets

ENSG00000131759

ENSEMBL

ENSP00000389993, ENST00000254066, ENSP00000254066, ENST00000394081, ENSP00000377649, ENST00000394089, ENSG00000131759, ENST00000425707, ENSP00000377643

ZINC - FDA approved

RARA_HUMAN

ZINC - Substances

RARA_HUMAN

ZINC - Biogenic

RARA_HUMAN

ZINC target

P10276

PRO

P10276

PDB

7QAA, 1DSZ, 3A9E, 3KMR, 7AOS, 4DQM, 1DKF, 3KMZ, 7WQQ, 7APO, 5K13, 6XWG

ZINC - Investigational

RARA_HUMAN

ZINC - Metabolites

RARA_HUMAN

GeneCards

RARA

HPA

ENSG00000131759-RARA

Pharos - Targets

P10276

Orphanet

RARA

ZINC - Predictions - Purchasable

RARA_HUMAN

HMDB Protein

HMDBP01910

Interactors (42)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P19793 RXRA	4	RXRA [nucleoplasm] (R-HSA-381319) monoSUMO1-K108-RXRA [nucleoplasm] (R-HSA-4341130) p-S21-RXRA [nucleoplasm] (R-HSA-5334811) RXRA [cytosol] (R-HSA-9619757)	0.951	15
UniProt:P28702 RXRB	1	RXRB [nucleoplasm] (R-HSA-446163)	0.949	16
UniProt:P48443 RXRG	1	RXRG [nucleoplasm] (R-HSA-446170)	0.944	18
UniProt:Q15788 NCOA1	3	NCOA1 [nucleoplasm] (R-HSA-442496) NCOA1 (868-1441) [nucleoplasm] (R-HSA-5603230) monoSUMO1-K732,K774-NCOA1 [nucleoplasm] (R-HSA-4085291)	0.869	7
UniProt:Q15648 MED1	1	MED1 [nucleoplasm] (R-HSA-212445)	0.818	6
UniProt:O75376 NCOR1	2	NCOR1 [nucleoplasm] (R-HSA-442501) NCOR1 [cytosol] (R-HSA-1253310)	0.802	6
UniProt:P48552 NRIP1	2	NRIP1 [nucleoplasm] (R-HSA-4086031) monoSUMO1-K756,K1154-NRIP1 [nucleoplasm] (R-HSA-4086057)	0.666	4
UniProt:Q8WW24 TEKT4			0.666	4
UniProt:Q91XC0 Ajuba	3	Ajuba [nucleoplasm] (R-MMU-5687969) phospho-Ajuba [cytosol] (R-MMU-2574841) Ajuba [cytosol] (R-MMU-2564698)	0.653	7
UniProt:Q9Y618 NCOR2	2	NCOR2 [nucleoplasm] (R-HSA-442469) monoSUMO1-K672-NCOR2 [nucleoplasm] (R-HSA-3927904)	0.647	4
UniProt:P59598	1	Asxl1 [nucleoplasm] (R-MMU-5689645)	0.61	4
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.597	4
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.577	3
UniProt:Q9Y6Q9 NCOA3	2	NCOA3 [nucleoplasm] (R-HSA-442488) p-S857 NCOA3 [nucleoplasm] (R-HSA-5687005)	0.564	2
UniProt:P50148 GNAQ	1	GNAQ [plasma membrane] (R-HSA-55453)	0.563	4
UniProt:Q96EZ8 MCRS1	1	MCRS1 [nucleoplasm] (R-HSA-3321849)	0.556	3
UniProt:Q96RK4 BBS4	1	BBS4 [cytosol] (R-HSA-5617635)	0.556	3
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382)	0.556	5
UniProt:P28702-3 RXRB			0.556	3
UniProt:Q9H8W4 PKHF2			0.556	3
UniProt:P13056-2 P130562			0.556	3
UniProt:O95273 CCDB1			0.556	3
UniProt:Q15699 ALX1			0.556	3
UniProt:P37231 PPARG	2	PPARG [nucleoplasm] (R-HSA-446172) monoSUMO1-K107,K395-PPARG [nucleoplasm] (R-HSA-4717444)	0.556	3
UniProt:O15296 ALOX15B	1	ALOX15B [cytosol] (R-HSA-2142725)	0.556	3
UniProt:P51946 CCNH	1	CCNH [nucleoplasm] (R-HSA-69220)	0.544	2
UniProt:P23771 GATA3	2	GATA3 [nucleoplasm] (R-HSA-996768) PolyUb-GATA3 [nucleoplasm] (R-HSA-6783009)	0.532	5
UniProt:P55317 FOXA1	1	FOXA1 [nucleoplasm] (R-HSA-453074)	0.532	4
UniProt:P42224 STAT1	8	STAT1 [cytosol] (R-HSA-629622) p-Y701-STAT1 [cytosol] (R-HSA-8951202) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-Y701-STAT1 [cytosol] (R-HSA-3132766) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-Y701,S727-STAT1 [cytosol] (R-HSA-9850842) p-STAT1 [cytosol] (R-HSA-8950418) p-STAT1 [nucleoplasm] (R-HSA-8987140)	0.532	4
UniProt:Q92754 TFAP2C	3	monoSUMO1-K10-TFAP2C [nucleoplasm] (R-HSA-3234071) TFAP2C [cytosol] (R-HSA-8864579) TFAP2C [nucleoplasm] (R-HSA-3234058)	0.532	4
UniProt:P13631 RARG	1	RARG [nucleoplasm] (R-HSA-446161)	0.527	2
UniProt:Q2M1K9 ZNF423	1	ZNF423 [nucleoplasm] (R-HSA-3222318)	0.524	2
UniProt:Q16236 NFE2L2	13	p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) ub-NFE2L2 [cytosol] (R-HSA-9758077) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736)	0.524	2
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.524	3
UniProt:O43707-1 ACTN4			0.524	2
UniProt:Q71SY5 MED25	1	MED25 [nucleoplasm] (R-HSA-212414)	0.508	10
UniProt:P78527 PRKDC	4	p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-HSA-76302) PRKDC [nucleoplasm] (R-HSA-62161) PRKDC [cytosol] (R-HSA-3134816) K48polyUb-PRKDC [cytosol] (R-HSA-8938766)	0.499	3
UniProt:Q9UKP3 ITBP2			0.499	2
UniProt:Q9UPP1-2 PHF8	2	PHF8-2 [nucleoplasm] (R-HSA-2245222) p-S33,84-PHF8-2 [nucleoplasm] (R-HSA-2245220)	0.499	2
UniProt:O75376-2 NCOR1			0.488	2
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.463	2
UniProt:P01100 FOS	2	FOS [nucleoplasm] (R-HSA-450216) p-T325,T331,S362,S374-FOS [nucleoplasm] (R-HSA-450283)	0.462	3