Reactome: A Curated Pathway Database

ESR1

Stable Identifier
R-HSA-446168
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Estrogen receptor, ESR1_HUMAN
Locations in the PathwayBrowser
External Reference Information
External Reference
Gene Names
ESR1, ESR, NR3A1
Chain
chain:1-595
Reference Genes
Reference Transcript
Other Identifiers
 0000360020  0104540528  11721785_a_at  11721786_a_at  11736904_a_at
 11750485_a_at  11756042_x_at  1298_at  1681_at  17013809
 1893_s_at  1A52  1AKF  1ERE  1ERR
 1G50  1GWQ  1GWR  1HCP  1HCQ
 1L2I  1PCG  1QKT  1QKU  1R5K
 1SJ0  1UOM  1X7E  1X7R  1XP1
 1XP6  1XP9  1XPC  1XQC  1YIM
 1YIN  1ZKY  205225_at  2099  211233_x_at
 211234_x_at  211235_s_at  215552_s_at  217163_at  217190_x_at
 2931764  2931765  2931775  2931776  2931779
 2931780  2931781  2931782  2931783  2931784
 2931785  2931798  2931799  2931812  2931821
 2931839  2931840  2931850  2931859  2931860
 2931861  2931862  2AYR  2B1V  2B1Z
 2B23  2BJ4  2FAI  2G44  2G5O
 2I0J  2IOG  2IOK  2JF9  2JFA
 2LLO  2LLQ  2OCF  2OUZ  2P15
 2POG  2Q6J  2Q70  2QA6  2QA8
 2QAB  2QE4  2QGT  2QGW  2QH6
 2QR9  2QSE  2QXM  2QXS  2QZO
 2R6W  2R6Y  2YAT  2YJA  33670_at
 37  3CBM  3CBO  3CBP  3DT3
 3ERD  3ERT  3HLV  3HM1  3L03
 3OS8  3OS9  3OSA  3Q95  3Q97
 3UU7  3UUA  3UUC  3UUD  449
 450  4AA6  4DMA  4IU7  4IUI
 4IV2  4IV4  4IVW  4IVY  4IW6
 4IW8  4IWC  4IWF  4JC3  4JDD
 4MG5  4MG6  4MG7  4MG8  4MG9
 4MGA  4MGB  4MGC  4MGD  4O6F
 4PP6  4PPP  4PPS  4PXM  4Q13
 4Q50  4TUZ  4TV1  4XI3  4ZN7
 4ZN9  4ZNH  4ZNS  4ZNT  4ZNU
 4ZNV  4ZNW  55099  5AAU  5AAV
 5ACC  5AK2  5DI7  5DID  5DIE
 5DIG  5DK9  5DKB  5DKE  5DKG
 5DKS  5DL4  5DLR  5DMC  5DMF
 5DP0  5DRJ  5DRM  5DTV  5DU5
 5DUE  5DUG  5DUH  5DVS  5DVV
 5DWE  5DWG  5DWI  5DWJ  5DX3
 5DXB  5DXE  5DXG  5DXK  5DXM
 5DXP  5DXQ  5DXR  5DY8  5DYB
 5DYD  5DZ0  5DZ1  5DZ3  5DZH
 5DZI  5E0W  5E0X  5E14  5E15
 5E19  5E1C  5EGV  5EHJ  5EI1
 5EIT  5FQP  5FQR  5FQS  5FQT
 5FQV  5HYR  5KCC  5KCD  5KCE
 5KCF  5KCT  5KCU  5KCW  5KD9
 5KR9  5KRA  5KRC  5KRF  5KRH
 5KRI  5KRJ  5KRK  5KRL  5KRM
 5KRO  5T0X  5T92  5T97  5TLD
 5TLF  5TLG  5TLL  5TLM  5TLO
 5TLP  5TLT  5TLU  5TLV  5TLX
 5TLY  5TM1  5TM2  5TM3  5TM4
 5TM5  5TM6  5TM7  5TM8  5TM9
 5TML  5TMM  5TMO  5TMQ  5TMR
 5TMS  5TMT  5TMU  5TMV  5TMW
 5TMZ  5TN1  5TN3  5TN4  5TN5
 5TN6  5TN7  5TN8  5TN9  5TNB
 5U2D  72858  8122840  8122843  A_14_P136162
 A_23_P309739  A_24_P325215  A_24_P383478  A_33_P3379356  AAA52399
 AAB00115  AAD52984  AAI28574  AAI28575  AAQ91815
 AEP43755  AH008151  AL049821  AL078582  AL356311
 AL590993  AY425004  BC128573  BC128574  BX640939
 CAA27284  CAA51528  CAA99436  CAB000037  CAB055099
 CAB072858  CAE45969  CCDS5234  CH471051  EAW47740
 ENSG00000091831  ENSP00000206249  ENSP00000342630  ENSP00000387500  ENSP00000405330
 ENST00000206249  ENST00000338799  ENST00000440973  ENST00000443427  EntrezGene:2099
 ESR1  ESR1-201  ESR1-202  ESR1-207  ESR1-208
 g11907834_3p_a_at  g4503602_3p_at  G4XH65  GE59651  GO:0000003
 GO:0000122  GO:0000228  GO:0000790  GO:0000978  GO:0001046
 GO:0001071  GO:0001077  GO:0001093  GO:0001547  GO:0002064
 GO:0002376  GO:0003674  GO:0003677  GO:0003682  GO:0003700
 GO:0003707  GO:0004871  GO:0004879  GO:0005496  GO:0005515
 GO:0005575  GO:0005622  GO:0005623  GO:0005634  GO:0005654
 GO:0005694  GO:0005737  GO:0005794  GO:0005886  GO:0006338
 GO:0006351  GO:0006355  GO:0006357  GO:0006366  GO:0006367
 GO:0006412  GO:0006461  GO:0006464  GO:0006629  GO:0006950
 GO:0007165  GO:0007200  GO:0007204  GO:0008013  GO:0008134
 GO:0008150  GO:0008209  GO:0008219  GO:0008270  GO:0008283
 GO:0008289  GO:0008584  GO:0009058  GO:0010629  GO:0010863
 GO:0016020  GO:0016021  GO:0016579  GO:0017025  GO:0019899
 GO:0019901  GO:0022607  GO:0030154  GO:0030234  GO:0030235
 GO:0030284  GO:0030331  GO:0030518  GO:0030520  GO:0030522
 GO:0032355  GO:0034056  GO:0034121  GO:0034641  GO:0035327
 GO:0038052  GO:0040007  GO:0042592  GO:0042802  GO:0042981
 GO:0043124  GO:0043167  GO:0043226  GO:0043234  GO:0043401
 GO:0043433  GO:0043565  GO:0043627  GO:0045893  GO:0045899
 GO:0045944  GO:0046872  GO:0048146  GO:0048856  GO:0048863
 GO:0050727  GO:0051091  GO:0051117  GO:0051276  GO:0060065
 GO:0060068  GO:0060523  GO:0060527  GO:0060687  GO:0060745
 GO:0060749  GO:0060750  GO:0065003  GO:0071168  GO:0071391
 GO:0071392  GO:0097550  GO:1903799  HGNC:3467  HPA000449
 HPA000450  Hs.208124  Hs.247938.0.S1_3p_at  Hs.247976.0.S1_3p_s_at  ILMN_1678535
 IPR000536  IPR001292  IPR001628  IPR001723  IPR013088
 IPR024178  IPR024736  JF810888  LRG_992  LRG_992t1
 M12674  NM_000125  NM_001122740  NM_001122741  NM_001122742
 NM_001291230  NM_001291241  NP_000116  NP_001116212  NP_001116213
 NP_001116214  NP_001278159  NP_001278170  PF00104  PF00105
 PF02159  PF12743  PR00047  PR00398  PR00543
 Q9H2M1  Q9H2M2  Q9UE35  SM00399  SM00430
 TC06001104.hg  TC06003132.hg  TC06003133.hg  U47678  uc003qom.5
 uc003qon.5  uc003qoo.5  uc010kin.4  UPI000004A328  X03635
 X03635_at  X73067  X86816_at  XM_006715374  XM_006715375
 XM_011535543  XM_011535544  XM_011535545  XM_011535547  XM_017010376
 XM_017010377  XM_017010378  XM_017010379  XM_017010380  XM_017010381
 XM_017010382  XM_017010383  XP_006715437  XP_006715438  XP_011533845
 XP_011533846  XP_011533847  XP_011533849  XP_016865865  XP_016865866
 XP_016865867  XP_016865868  XP_016865869  XP_016865870  XP_016865871
 XP_016865872  XR_001743222  XR_001743223  Z75126
Participant Of
Inferred To
Cross References
ZINC - World Drugs
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
PDB
5TLT, 3HM1, 5TLU, 5TLP, 3HLV, 5TLV, 3OS8, 5TLX, 3OS9, 3L03, 3DT3, 3CBO, 5TLF, 3CBP, 5TLG, 5TLO, 3ERT, 5TLL, 3ERD, 5TLM, 2YAT, 5T92, 2R6Y, 5T0X, 5TLD, 2YJA, 5T97, 3CBM, 2QXM, 5KRL, 2QXS, 5KRM, 5KRK, 2QSE, 5KRO, 2R6W, 5N10, 2QZO, 5TMS, 4IVY, 4IW6, 5TMR, 4IWC, 5TMT, 4IW8, 5TMU, 5TML, 5TMM, 4IUI, 4IV2, 5TM9, 4IU7, 5TMQ, 4IV4, 4IVW, 5TMO, 5TM6, 5TM4, 3UUA, 5TM5, 3UUC, 5TM8, 4DMA, 3UUD, 4AA6, 5TM7, 5TM1, 3Q95, 5TLY, 3OSA, 5TM3, 3UU7, 5TM2, 3Q97, 2G44, 5FQP, 5EI1, 5EIT, 2FAI, 5FQS, 5FQT, 2IOG, 5FQR, 2G5O, 2I0J, 2B1V, 2AYR, 5E19, 5E1C, 2BJ4, 2B1Z, 5EGV, 5EHJ, 2B23, 5E0W, 5E0X, 1YIM, 1XPC, 1XQC, 5E15, 1ZKY, 1YIN, 5E14, 1XP1, 5DZ1, 5DZ3, 5DZ0, 1X7R, 5DZH, 5DZI, 1XP6, 1XP9, 2QGW, 5KRH, 2QE4, 5KRC, 5KRF, 2QGT, 2QR9, 5KRJ, 5KRI, 2QH6, 5KD9, 2QA6, 2Q70, 5KCW, 5KRA, 2QAB, 2QA8, 5KR9, 5KCF, 2OUZ, 2P15, 2OCF, 5KCE, 2Q6J, 5KCT, 2POG, 5KCU, 5HYR, 2JFA, 5JMM, 5FQV, 2IOK, 2JF9, 5KCD, 2LLQ, 2LLO, 5KCC, 5DTV, 5DU5, 5DUE, 5DUG, 5DMF, 5DP0, 5DRM, 5DRJ, 5DKS, 5DL4, 5DKG, 5DLR, 5DMC, 5DIE, 5DIG, 5DKE, 5DK9, 5DKB, 1R5K, 1SJ0, 5DXQ, 5DXR, 1UOM, 1X7E, 5DYD, 5DY8, 5DYB, 5DXK, 1L2I, 1HCP, 1HCQ, 5DXG, 1QKT, 1QKU, 1PCG, 5DXM, 5DXP, 5DWJ, 5DX3, 1ERR, 1G50, 5DXB, 5DXE, 1GWQ, 1GWR, 1A52, 5DVV, 5DUH, 5DVS, 1ERE, 5DWG, 5DWI, 5DWE, 1AKF, 4PPS, 4PPP, 4PXM, 4Q13, 5TNB, 4MGC, 4MGD, 5TN9, 4O6F, 4PP6, 5U2B, 5U2D, 5TN5, 5TN6, 4MG8, 5TN4, 4MG6, 4MG7, 5TN8, 4MGA, 4MGB, 4MG9, 5TN7, 5TMZ, 5TMV, 5TMW, 4IWF, 4JC3, 5TN3, 5TN1, 4JDD, 4MG5, 5AK2, 5ACC, 5DI7, 5DID, 4ZNV, 4ZNW, 5AAV, 5AAU, 4ZNH, 4ZNS, 4ZN9, 4ZNT, 4ZNU, 4Q50, 4XI3, 4TV1, 4ZN7, 4TUZ
UCSC human
ZINC - Metabolites
GeneCards
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors
Confidence Score Interactor Accession Interactor Name Evidence (IntAct)
0.92 Q15788 NCOA1_HUMAN 10
0.839 P03372 ESR1_HUMAN 9
0.826 P17844 DDX5_HUMAN 9
0.783 Q04206 TF65_HUMAN 7
0.782 Q92841 DDX17_HUMAN 8
0.774 P06401 PRGR_HUMAN 20
0.756 P38398 BRCA1_HUMAN 14
0.75 P55345 ANM2_HUMAN 9
0.725 EBI-5590876 TFF1_HUMAN_GENE 5
0.708 P12931 SRC_HUMAN 9
0.705 Q15596 NCOA2_HUMAN 8
0.69 P05388 RLA0_HUMAN 4
0.69 P62701 RS4X_HUMAN 4
0.688 Q9Y6Q9 NCOA3_HUMAN 4
0.676 P19838-PRO_0000030311 NFKB1 3
0.643 Q9H1R3 MYLK2_HUMAN 3
0.643 P60709 ACTB_HUMAN 4
0.643 Q13547 HDAC1_HUMAN 5
0.642 P60660 MYL6_HUMAN 3
0.639 P60763 RAC3_HUMAN 5
0.639 Q96AQ6 PBIP1_HUMAN 9
0.633 Q8N895 ZN366_HUMAN 6
0.625 P53041 PPP5_HUMAN 4
0.623 P23771 GATA3_HUMAN 4
0.616 P05627 JUN_MOUSE 6
0.609 Q9Y3R0 GRIP1_HUMAN 2
0.597 P62854 RS26_HUMAN 3
0.597 P21333 FLNA_HUMAN 3
0.597 P11142 HSP7C_HUMAN 3
0.597 P10276 RARA_HUMAN 4
0.597 P35579 MYH9_HUMAN 3
0.597 Q969Q0 RL36L_HUMAN 3
0.597 P62263 RS14_HUMAN 3
0.597 P06396 GELS_HUMAN 3
0.593 Q12802 AKP13_HUMAN 3
0.593 P06401-1 PGR 4
0.593 Q9Y6C7 L3R2A_HUMAN 3
0.589 Q09472 EP300_HUMAN 2
0.581 O43251 RFOX2_HUMAN 4
0.581 Q9BQ69 MACD1_HUMAN 4
0.576 EBI-10099285 VITA2_XENLA_ERE-SITE_DNA-PROBE 5
0.571 Q86Y37 CACL1_HUMAN 5
0.564 P48552 NRIP1_HUMAN 3
0.558 Q13330 MTA1_HUMAN 4
0.558 Q02447 SP3_HUMAN 2
0.558 P08047 SP1_HUMAN 2
0.556 P62962 PROF1_MOUSE 3
0.556 Q16881-4 TXNRD1 4
0.544 EBI-2695616 ERE_DNA 2
0.544 Q14151 SAFB2_HUMAN 2
0.537 P51532 SMCA4_HUMAN 3
0.532 P06748 NPM_HUMAN 3
0.532 Q92731 ESR2_HUMAN 3
0.527 P06576 ATPB_HUMAN 2
0.527 P05089 ARGI1_HUMAN 2
0.527 Q7Z406 MYH14_HUMAN 2
0.527 P05109 S10A8_HUMAN 2
0.527 P62952 BLCAP_HUMAN 2
0.527 Q9Y230 RUVB2_HUMAN 2
0.527 P62269 RS18_HUMAN 2
0.527 EBI-1265559 MYC_HUMAN_GENE 3
0.527 Q9Y294 ASF1A_HUMAN 2
0.527 Q8IXJ9 ASXL1_HUMAN 2
0.527 O00165 HAX1_HUMAN 2
0.527 Q9UN36 NDRG2_HUMAN 2
0.527 P25398 RS12_HUMAN 2
0.527 P60866 RS20_HUMAN 2
0.527 Q96HI0 SENP5_HUMAN 2
0.527 O95793 STAU1_HUMAN 2
0.527 Q8NHW5 RLA0L_HUMAN 2
0.527 O00429 DNM1L_HUMAN 2
0.525 O14686 KMT2D_HUMAN 3
0.524 Q9H467 CUED2_HUMAN 2
0.524 Q99966 CITE1_HUMAN 3
0.524 Q9BTK6 PAGR1_HUMAN 5
0.524 P42229 STA5A_HUMAN 2
0.512 Q12873 CHD3_HUMAN 4
0.508 Q12778 FOXO1_HUMAN 2
0.508 Q00987 MDM2_HUMAN 2
0.508 Q9JLI4 NCOA6_RAT 2
0.508 P20290-2 BTF3 5
0.508 Q99623 PHB2_HUMAN 4
0.508 P59598 ASXL1_MOUSE 2
0.499 O94776 MTA2_HUMAN 3
0.499 Q9BTC8 MTA3_HUMAN 3
0.488 Q9NPJ4 PNRC2_HUMAN 2
0.482 Q925T6 GRIP1_MOUSE 2
0.462 Q9Y2W1 TR150_HUMAN 2
0.462 Q5JTH9 RRP12_HUMAN 2
0.462 Q08211 DHX9_HUMAN 2
0.462 Q96HS1 PGAM5_HUMAN 2
0.462 Q96GQ7 DDX27_HUMAN 2
0.462 P35268 RL22_HUMAN 2
0.462 P02786 TFR1_HUMAN 2
0.462 P02787 TRFE_HUMAN 2
0.462 P61247 RS3A_HUMAN 2
0.462 Q96PK6 RBM14_HUMAN 2
0.462 Q00610 CLH1_HUMAN 2
0.462 P50914 RL14_HUMAN 2
0.462 Q02878 RL6_HUMAN 2
0.462 Q9P035 HACD3_HUMAN 2
0.462 Q02880 TOP2B_HUMAN 2
0.462 Q14669 TRIPC_HUMAN 2
0.462 Q8IY81 SPB1_HUMAN 2
0.462 P61513 RL37A_HUMAN 2
0.462 P17480 UBF1_HUMAN 2
0.462 P05141 ADT2_HUMAN 2
0.462 P83881 RL36A_HUMAN 2
0.462 A0A024RC46 A0A024RC46_HUMAN 2
0.462 O76021 RL1D1_HUMAN 2
0.462 P38159 RBMX_HUMAN 2
0.462 P68032 ACTC_HUMAN 2
0.462 Q9NR30 DDX21_HUMAN 2
0.462 P14923 PLAK_HUMAN 2
0.462 P04844 RPN2_HUMAN 2
0.462 Q92769 HDAC2_HUMAN 2
0.462 P04843 RPN1_HUMAN 2
0.462 Q07020 RL18_HUMAN 2
0.462 Q6PJG2 EMSA1_HUMAN 2
0.462 Q14498 RBM39_HUMAN 2
0.462 Q8IYB3 SRRM1_HUMAN 2
0.462 P39023 RL3_HUMAN 2
0.462 Q8IZL8 PELP1_HUMAN 2
0.462 Q9BZE4 NOG1_HUMAN 2
0.462 Q01844 EWS_HUMAN 2
0.462 Q12905 ILF2_HUMAN 2
0.462 Q9H0A0 NAT10_HUMAN 2
0.462 P52597 HNRPF_HUMAN 2
0.462 P0CG47 UBB_HUMAN 2
0.462 O43390 HNRPR_HUMAN 2
0.462 P62424 RL7A_HUMAN 2
0.462 P61978 HNRPK_HUMAN 2
0.462 P26368 U2AF2_HUMAN 2
0.462 Q07955 SRSF1_HUMAN 2
0.462 Q02543 RL18A_HUMAN 2
0.462 P15880 RS2_HUMAN 2
0.462 P62266 RS23_HUMAN 2
0.462 O60832 DKC1_HUMAN 2
0.462 O00571 DDX3X_HUMAN 2
0.462 O43823 AKAP8_HUMAN 2
0.462 P26373 RL13_HUMAN 2
0.462 Q32P51 RA1L2_HUMAN 2
0.462 O43143 DHX15_HUMAN 2
0.462 Q9NVI7 ATD3A_HUMAN 2
0.462 P09874 PARP1_HUMAN 2
0.462 P40429 RL13A_HUMAN 2
0.462 P11387 TOP1_HUMAN 2
0.462 P18621 RL17_HUMAN 2
0.462 O00567 NOP56_HUMAN 2
0.462 P11388 TOP2A_HUMAN 2
0.462 P11940 PABP1_HUMAN 2
0.462 Q9NYF8 BCLF1_HUMAN 2
0.462 Q9BVP2 GNL3_HUMAN 2
0.462 P35637 FUS_HUMAN 2
0.462 P62249 RS16_HUMAN 2
0.462 Q14980 NUMA1_HUMAN 2
0.462 P46776 RL27A_HUMAN 2
0.462 P27635 RL10_HUMAN 2
0.462 P46013 KI67_HUMAN 2
0.462 P61313 RL15_HUMAN 2
0.462 P62241 RS8_HUMAN 2
0.462 P84098 RL19_HUMAN 2
0.462 Q9NVP1 DDX18_HUMAN 2
0.462 P19338 NUCL_HUMAN 2
0.462 O00159 MYO1C_HUMAN 2
0.462 P36578 RL4_HUMAN 2
0.462 P46781 RS9_HUMAN 2
0.462 P51991 ROA3_HUMAN 2
0.462 P62753 RS6_HUMAN 2
0.462 P09651 ROA1_HUMAN 2
0.462 P83731 RL24_HUMAN 2
0.462 Q9BQG0 MBB1A_HUMAN 2
0.462 Q8TDD1 DDX54_HUMAN 2
0.462 Q01130 SRSF2_HUMAN 2
0.462 P18124 RL7_HUMAN 2
0.462 P62917 RL8_HUMAN 2
0.462 P52272 HNRPM_HUMAN 2
0.462 O43795 MYO1B_HUMAN 2
0.462 Q16629 SRSF7_HUMAN 2
0.462 Q14444 CAPR1_HUMAN 2