Reactome | ESR1 [nucleoplasm]

ESR1 [nucleoplasm]

Stable Identifier

R-HSA-446168

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Estrogen receptor, ESR1_HUMAN

Icon

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P03372 ESR1

Gene Names

ESR1, ESR, NR3A1

Chain

chain:1-595

Reference Genes

BioGPS Gene:2099 ESR1

COSMIC (genes):ESR1 ESR1

CTD Gene:2099 ESR1

dbSNP Gene:2099 ESR1

ENSEMBL:ENSG00000091831 ESR1

ENSEMBL_homo_sapiens_GENE:ENSG00000091831.25 ESR1

HGNC:3467 ESR1

KEGG Gene (Homo sapiens):2099 ESR1

Monarch:2099 ESR1

NCBI Gene:2099 ESR1

OMIM:133430 ESR1

UCSC:P03372 ESR1

Reference Transcript

Other Identifiers

11721785_a_at

11721786_a_at

11736904_a_at

11750485_a_at

11756042_x_at

1298_at

1681_at

17013809

1893_s_at

205225_PM_at

205225_at

2099

211233_PM_x_at

211233_x_at

211234_PM_x_at

211234_x_at

211235_PM_s_at

211235_s_at

215552_PM_s_at

215552_s_at

217163_at

217190_x_at

2931764

2931765

2931774

2931775

2931776

2931779

2931780

2931781

2931782

2931783

2931784

2931785

2931788

2931798

2931799

2931812

2931821

2931839

2931840

2931850

2931859

2931860

2931861

2931862

2931863

2931877

2931878

2931879

2931880

2931881

2931882

2931883

2931884

2931885

2931886

2931887

2931888

33670_at

8122840

8122843

A_14_P136162

A_23_P309739

A_24_P325215

A_24_P383478

A_33_P3379356

GE59651

GE611264

GO:0000122

GO:0000785

GO:0000791

GO:0000978

GO:0000981

GO:0001093

GO:0001221

GO:0001222

GO:0001223

GO:0001228

GO:0001547

GO:0002064

GO:0002376

GO:0003677

GO:0003682

GO:0003700

GO:0003707

GO:0004879

GO:0005496

GO:0005515

GO:0005516

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005737

GO:0005794

GO:0005829

GO:0005886

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0006629

GO:0006954

GO:0007165

GO:0007186

GO:0007200

GO:0007204

GO:0008013

GO:0008209

GO:0008270

GO:0008289

GO:0008584

GO:0010629

GO:0010863

GO:0012501

GO:0016020

GO:0017025

GO:0019899

GO:0019901

GO:0022414

GO:0023052

GO:0030154

GO:0030235

GO:0030284

GO:0030331

GO:0030518

GO:0030520

GO:0030522

GO:0032355

GO:0032991

GO:0034056

GO:0034121

GO:0034392

GO:0038054

GO:0042802

GO:0043124

GO:0043226

GO:0043401

GO:0043433

GO:0043565

GO:0043627

GO:0045893

GO:0045944

GO:0046872

GO:0048144

GO:0048146

GO:0048856

GO:0048863

GO:0050727

GO:0051091

GO:0051117

GO:0051123

GO:0060065

GO:0060068

GO:0060089

GO:0060523

GO:0060527

GO:0060687

GO:0060745

GO:0060749

GO:0060750

GO:0065003

GO:0071168

GO:0071391

GO:0071392

GO:0071889

GO:0098542

GO:0098772

GO:0140110

GO:1902894

GO:1904035

GO:1990837

HMNXSV003001759

Hs.247938.0.S1_3p_at

Hs.247976.0.S1_3p_s_at

ILMN_1678535

TC06001104.hg

TC06003132.hg

TC06003133.hg

X03635_at

X86816_at

g11907834_3p_a_at

g4503602_3p_at

Participates

as a component of

as a member of

as an input of

as an output of

TFAP2A,TFAP2C homodimers stimulate ESR1 gene expression (Homo sapiens)

Other forms of this molecule

p-S118-ESR1 [nucleoplasm]

monoSUMO1-5K-ESR1 [nucleoplasm]

p-S167-ESR1 [nucleoplasm]

p-S167-ESR1 [cytosol]

Me260-ESR1 [cytosol]

PalmS-ESR1 [cytosol]

Me260-PalmS-ESR1 [plasma membrane]

PalmS-ESR1 [plasma membrane]

ESR1 [cytosol]

Inferred To

Ghost homologue of ESR1 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of ESR1 [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of ESR1 [nucleoplasm] (Plasmodium falciparum)

Ghost homologue of ESR1 [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of ESR1 [nucleoplasm] (Schizosaccharomyces pombe)

knrl [nucleoplasm] (Drosophila melanogaster)

ESR1 [nucleoplasm] (Bos taurus)

ESR1 [nucleoplasm] (Canis familiaris)

ESR1 [nucleoplasm] (Gallus gallus)

ESR1 [nucleoplasm] (Mus musculus)

ESR1 [nucleoplasm] (Rattus norvegicus)

ESR1 [nucleoplasm] (Sus scrofa)

esr1 [nucleoplasm] (Danio rerio)

esr1 [nucleoplasm] (Xenopus tropicalis)

ERR [nucleoplasm] (Drosophila melanogaster)

kni [nucleoplasm] (Drosophila melanogaster)

Homologues of ESR1 [nucleoplasm] (Drosophila melanogaster)

eg [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

XP_011533847.1, NP_001278159.1, XP_006715438.1, NP_000116.2, XP_016865868.1, XP_016865866.1, NP_001116212.1, NP_001116213.1, XP_011533845.1, XP_016865869.1, NP_001116214.1, NP_001278170.1, XP_011533846.1, XP_016865870.1, XP_016865865.1, XP_016865867.1, NP_001315029.1

ZINC - World Drugs

ESR1_HUMAN

Guide to Pharmacology - Targets

620

OpenTargets

ENSG00000091831

ZINC - FDA approved

ESR1_HUMAN

ZINC - Substances

ESR1_HUMAN

ZINC target

P03372

ZINC - Biogenic

ESR1_HUMAN

PRO

P03372

PDB

2QR9, 5DZ3, 8BWJ, 2QSE, 7B9T, 7BA5, 8EV2, 8ALW, 8BZ0, 5DKG, 7T2X, 6VGH, 3UUC, 8AV4, 7UJO, 6HMU, 6D0F, 2QE4, 4ZNT, 5T97, 2B1Z, 2I0J, 5TM4, 5KCF, 5DRM, 5TN9, 5WGD, 8BZW, 8DVB, 5TM5, 1QKU, 5DU5, 8BXI, 1X7R, 8BX0, 8AWG, 3OSA, 5WGQ, 2QXM, 5KCD, 2QH6, 6VPF, 2OUZ, 8BYD, 2LLO, 7UJC, 4MGB, 8DU9, 7B9R, 5T92, 7BA3, 6VJD, 5KRC, 8AR5, 4MG8, 5FQR, 7PWZ, 4IUI, 2B1V, 2JFA, 5TN5, 5KCC, 3OS8, 5DY8, 4XI3, 8DUC, 2LLQ, 3ERD, 8BYE, 1ERE, 5DXR, 7QVJ, 5TMU, 5E1C, 5TLP, 8ARQ, 8BZF, 4ZNU, 5TN7, 5TMO, 2QGW, 3HLV, 7QVL, 8BX4, 6HHP, 5TMQ, 7RS0, 6SBO, 5E0X, 5KCW, 1R5K, 2Q6J, 4TUZ, 8AV8, 2P15, 5KRF, 7UJF, 1QKT, 8ARZ, 5KD9, 8ALR, 5KRH, 8BWZ, 4MGA, 5KCT, 2YJA, 8ARG, 6CZN, 4IVW, 5DTV, 5TM3, 5KCE, 7BAB, 2Q70, 7RS2, 5TNB, 6SQ0, 5KRJ, 8BZC, 8C0K, 7YMK, 7RS3, 5U2B, 8BYB, 5E19, 8AU2, 5TN1, 5KR9, 4IWF, 4DMA, 7NFB, 4MG7, 8BYO, 7UJY, 7JHD, 5DZ1, 6PET, 2QA6, 5EIT, 5KRA, 8DV8, 4ZN7, 5DKB, 8B39, 4PPP, 8AV3, 1XPC, 8AUY, 1UOM, 8ARR, 7UJM, 5DI7, 4IW8, 8C4F, 5TM6, 8AS1, 1GWQ, 5TM7, 8C42, 5DXG, 3CBP, 7BA6, 4ZNS, 8DUB, 4Q13, 4MG6, 8EV1, 8ARW, 4MG9, 5E15, 7SFO, 6CHW, 4Q50, 3L03, 4ZN9, 7NEL, 8ANF, 5TLT, 5DXQ, 2QAB, 8BYC, 8BX3, 5FQV, 5TLU, 5W9D, 2QXS, 5DX3, 5DXP, 4ZNH, 2QGT, 7R62, 7RS1, 7RS4, 5W9C, 8BYF, 6HKF, 8ALV, 2QA8, 4IV2, 8AT9, 5DWJ, 7RS7, 8DU8, 8DV7, 8AV7, 5TMR, 5FQT, 3OS9, 5DUE, 5DKE, 5TLF, 8BWX, 5TMW, 5DZH, 2JF9, 2G5O, 6WOK, 5TMS, 2R6Y, 8ARO, 8BYG, 7NDO, 5N10, 1A52, 8BZ9, 2AYR, 7TE7, 5TM1, 6TL3, 1HCQ, 4PPS, 8BXO, 6V87, 8BZA, 5HYR, 4IWC, 8C04, 7BA8, 1XP9, 6PFM, 5TN4, 6DF6, 1ERR, 2BJ4, 4MG5, 5TMZ, 5T1Z, 8AZE, 5DIG, 8ARY, 5TM9, 5DXE, 8AQC, 6DFN, 8AUS, 4JDD, 8BY9, 8AOY, 2OCF, 8ARX, 7NIZ, 5EHJ, 7RNM, 4AA6, 3UUA, 7RKE, 4IVY, 5TMT, 6ZOR, 7RS8, 2IOK, 1L2I, 5TM8, 1GWR, 4PXM, 7UJW, 8DV5, 5TLG, 5DID, 6ZOQ, 6CHZ, 5DL4, 1XP6, 5DK9, 2R6W, 8ATP, 5GS4, 5DVV, 6V8T, 1X7E, 5DXK, 6CBZ, 5DZ0, 5DMF, 2G44, 5DWG, 5DLR, 6PSJ, 6PIT, 1ZKY, 5UFW, 5DMC, 8APS, 8AQE, 3DT3, 5DVS, 7Y8F, 5DXM, 7N9O, 4IU7, 7MSA, 5TLD, 5TLV, 5DIE, 8AM7, 3CBO, 5DXB, 5TLX, 5DWI, 7NFW, 5UFX, 6SUO, 5GTR, 8BXS, 1XQC, 5TN6, 8C4G, 3Q95, 1HCP, 3UUD, 5TLO, 5FQS, 5DZI, 5AAU, 7BAA, 2FAI, 3CBM, 4O6F, 8DUI, 4ZNV, 4MGD, 4JC3, 7PWT, 5TM2, 6HKB, 5KRI, 4IV4, 8BYZ, 8BXN, 1PCG, 7RRZ, 5KRM, 5TMV, 8AFN, 1XP1, 2YAT, 7B9M, 8DU6, 5TN8, 7RS9, 2POG, 5DRJ, 5EGV, 5TMM, 5DUG, 8DUD, 7RRY, 1YIN, 5AAV, 8ALT, 5KCU, 2IOG, 2QZO, 5U2D, 8DUG, 7OQ8, 4TV1, 7UJ7, 5JMM, 5KRO, 5DKS, 6IAR, 5KRK, 7UJ8, 6B0F, 6OWC, 5DUH, 8BZB, 4ZNW, 5E0W, 3UU7, 5TML, 4PP6, 7Y8G, 5TLL, 8AQZ, 5DYD, 3ERT, 7WNV, 5DYB, 2B23, 5DP0, 5TLM, 7OQ7, 5E14, 1G50, 3HM1, 8BXM, 8AXU, 8BYY, 7BA9, 8AQ1, 5TN3, 8DUH, 7KBS, 7RRX, 8AI0, 4MGC, 5T0X, 5KRL, 7BA7, 7OPW, 8AXE, 5EI1, 6C42, 5DWE, 5FQP, 8AR4, 6ZOS, 8DUK, 1YIM, 5TLY, 5AK2, 6TJM, 8BXQ, 4IW6, 1SJ0, 5ACC, 8DUS

ZINC - Investigational

ESR1_HUMAN

ZINC - Metabolites

ESR1_HUMAN

GeneCards

P03372

HPA

ENSG00000091831-ESR1

Ensembl

ENSP00000206249, ENSP00000394721, ENSP00000405330, ENSG00000091831, ENST00000443427, ENST00000206249, ENST00000338799, ENSP00000387500, ENST00000440973, ENST00000427531, ENSP00000342630

Pharos - Targets

P03372

ZINC - Predictions - Purchasable

ESR1_HUMAN

Orphanet

15995

Interactors (271)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.87	11
UniProt:P12931 SRC	6	p-Y419-SRC [nucleoplasm] (R-HSA-8937690) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.848	12
UniProt:Q15788 NCOA1	3	monoSUMO1-K732,K774-NCOA1 [nucleoplasm] (R-HSA-4085291) NCOA1 (868-1441) [nucleoplasm] (R-HSA-5603230) NCOA1 [nucleoplasm] (R-HSA-442496)	0.835	8
UniProt:Q04206 RELA	7	MeK310-RELA [nucleoplasm] (R-HSA-8865233) p-S536-RELA [nucleoplasm] (R-HSA-9861499) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.832	9
UniProt:P38398 BRCA1	20	polySUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) monoSUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) BRCA1 M1411T [nucleoplasm] (R-HSA-9702140) BRCA1 M1400V [nucleoplasm] (R-HSA-9701202) BRCA1 L1407P [nucleoplasm] (R-HSA-9702135) BRCA1 Y777* [nucleoplasm] (R-HSA-9702765) BRCA1 S1009* [nucleoplasm] (R-HSA-9702755) BRCA1 P724Lfs12 [nucleoplasm] (R-HSA-9703778) BRCA1 S451 [nucleoplasm] (R-HSA-9702754) BRCA1 S864* [nucleoplasm] (R-HSA-9702752) BRCA1 P897Kfs5 [nucleoplasm] (R-HSA-9703782) BRCA1 N555Kfs17 [nucleoplasm] (R-HSA-9703781) BRCA1 Y1127Sfs6 [nucleoplasm] (R-HSA-9703780) BRCA1 S886Cfs16 [nucleoplasm] (R-HSA-9703802) BRCA1 V83Cfs2 [nucleoplasm] (R-HSA-9703800) BRCA1 T464Pfs11 [nucleoplasm] (R-HSA-9703807) BRCA1 G813Dfs2 [nucleoplasm] (R-HSA-9703549) BRCA1 V340Gfs6 [nucleoplasm] (R-HSA-9703804) BRCA1 Y655* [nucleoplasm] (R-HSA-9702769) BRCA1 W372* [nucleoplasm] (R-HSA-9702768)	0.811	16
IntAct:EBI-5590876 TFF1			0.788	6
UniProt:P06401 PGR	3	monoSUMO1-K7,K388,K531-PGR [nucleoplasm] (R-HSA-4341032) PGR [cytosol] (R-HSA-8948964) PGR [nucleoplasm] (R-HSA-3008952)	0.774	20
UniProt:P55345 ANM2			0.75	9
UniProt:Q6PL18 ATAD2	1	ATAD2 [nucleoplasm] (R-HSA-8937250)	0.737	5
UniProt:Q9H1R3 MYLK2			0.725	5
UniProt:P60709 ACTB	5	Unfolded ACTB [cytosol] (R-HSA-390462) ACTB [nucleoplasm] (R-HSA-3321990) ACTB [cytosol] (R-HSA-201861) ACTB [lysosomal membrane] (R-HSA-196160) ACTB [plasma membrane] (R-HSA-196016)	0.723	6
UniProt:P62701 RPS4X	2	RPS4X [nucleoplasm] (R-HSA-6798713) RPS4X [cytosol] (R-HSA-72375)	0.69	4
UniProt:P05388 RPLP0	1	RPLP0 [cytosol] (R-HSA-72396)	0.69	4
UniProt:P62854 RPS26	2	RPS26 [nucleoplasm] (R-HSA-6798708) RPS26 [cytosol] (R-HSA-72359)	0.69	5
UniProt:Q969Q0 RPL36AL	1	RPL36AL [cytosol] (R-HSA-8868805)	0.69	5
UniProt:Q9BQ69 MACD1			0.69	6
UniProt:Q9Y6Q9 NCOA3	2	NCOA3 [nucleoplasm] (R-HSA-442488) p-S857 NCOA3 [nucleoplasm] (R-HSA-5687005)	0.688	4
UniProt:P29279 CTGF	1	CTGF [extracellular region] (R-HSA-561148)	0.682	7
UniProt:P19838-PRO_0000030311 NFKB1			0.676	3
UniProt:Q02447 SP3	3	monoSUMO1-K551-SP3 [nucleoplasm] (R-HSA-3247472) polySUMO2-K551-SP3 [nucleoplasm] (R-HSA-6804456) SP3 [nucleoplasm] (R-HSA-2160951)	0.667	4
UniProt:Q6NYC1 JMJD6	1	JMJD6 [nucleoplasm] (R-HSA-4754226)	0.649	8
UniProt:Q9Y294 ASF1A	1	ASF1A [nucleoplasm] (R-HSA-417169)	0.647	4
UniProt:P06576 ATP5F1B	6	ATP5F1B [mitochondrial matrix] (R-HSA-164576) ATP5B(1-47) [mitochondrial matrix] (R-HSA-8986172) ATP5B(1-529) [cytosol] (R-HSA-1267973) ATP5B(1-529) [mitochondrial intermembrane space] (R-HSA-1267985) ATP5B(1-529) [mitochondrial inner membrane] (R-HSA-1299440) ATP5B [mitochondrial inner membrane] (R-HSA-1299441)	0.643	4
UniProt:P17844 DDX5	4	DDX5 [nucleoplasm] (R-HSA-3900136) DDX5 [cytosol] (R-HSA-9682643) polySUMO2-K53-DDX5 [nucleoplasm] (R-HSA-3900186) monoSUMO1-K53-DDX5 [nucleoplasm] (R-HSA-3900041)	0.643	4
UniProt:P60660 MYL6	2	p-S20-MYL6 [cytosol] (R-HSA-445778) MYL6 [cytosol] (R-HSA-419186)	0.642	3
UniProt:O15164 TRIM24	4	TRIM24(1-626)-FGFR1(429-822) fusion [cytosol] (R-HSA-1614442) TRIM24(1-626)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1839012) TRIM24(1-510)-BRAF(381-766) fusion [cytosol] (R-HSA-6802477) TRIM24(1-510)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802555)	0.641	3
UniProt:P60763 RAC3	3	RAC3 [endoplasmic reticulum membrane] (R-HSA-9714693) RAC3 [plasma membrane] (R-HSA-195338) RAC3 [cytosol] (R-HSA-195335)	0.639	5
UniProt:Q8N895 ZN366			0.633	6
UniProt:O43524 FOXO3	11	p-S215 FOXO3 [nucleoplasm] (R-HSA-5687010) p-S215 FOXO3 [cytosol] (R-HSA-5687014) FOXO3 [cytosol] (R-HSA-5687032) p-S43,S173,S294,S325-FOXO3 [nucleoplasm] (R-HSA-8870627) p-S43,S173,S294,S325-FOXO3 [cytosol] (R-HSA-8870560) FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841824) Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841849) Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] (R-HSA-9620514) p-T32,S253,S315-FOXO3 [cytosol] (R-HSA-9614413) p-T32,S253,S315-FOXO3 [nucleoplasm] (R-HSA-199289) FOXO3 [nucleoplasm] (R-HSA-199305)	0.632	7
UniProt:Q03989 ARI5A			0.625	9
UniProt:P53041 PPP5C	2	PPP5C [cytosol] (R-HSA-5675402) PPP5C [nucleoplasm] (R-HSA-5683410)	0.625	4
UniProt:P23771 GATA3	2	GATA3 [nucleoplasm] (R-HSA-996768) PolyUb-GATA3 [nucleoplasm] (R-HSA-6783009)	0.623	4
UniProt:P05627 Jun	5	p-S63,S73-Jun [cytosol] (R-MMU-8868678) Jun [cytosol] (R-MMU-8868685) Jun [nucleoplasm] (R-MMU-3261183) phospho-Jun [nucleoplasm] (R-MMU-450237) Jun [nucleoplasm] (R-MMU-450250)	0.616	6
UniProt:Q9Y3R0 GRIP1	2	GRIP1 [cytosol] (R-HSA-416633) GRIP1 [plasma membrane] (R-HSA-416638)	0.609	2
UniProt:Q5JTH9 RRP12			0.597	4
UniProt:Q00610 CLTC	10	CLTC [trans-Golgi network membrane] (R-HSA-5333703) CLTC [cytosol] (R-HSA-8856820) CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-ALK(1058-1620) fusion [cytosol] (R-HSA-9710852) CLTC(2-1634)insV-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9710854) CLTC [plasma membrane] (R-HSA-2980668) CLTC [lysosomal membrane] (R-HSA-2980660) CLTC [clathrin-coated endocytic vesicle membrane] (R-HSA-5138450) CLTC [endolysosome membrane] (R-HSA-8870827) CLTC(2-1634)insV-ALK(1059-1620) fusion [cytosol] (R-HSA-9710853) CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9710835)	0.597	3
UniProt:P61513 RPL37A	1	RPL37A [cytosol] (R-HSA-72468)	0.597	4
UniProt:P27635 RPL10	1	RPL10 [cytosol] (R-HSA-72402)	0.597	4
UniProt:Q96GQ7 DDX27			0.597	4
UniProt:Q9BVP2 GNL3	1	GNL3 [nucleoplasm] (R-HSA-8869324)	0.597	4
UniProt:O43823 AKAP8			0.597	4
UniProt:P62263 RPS14	2	RPS14 [nucleoplasm] (R-HSA-6790669) RPS14 [cytosol] (R-HSA-72333)	0.597	3
UniProt:Q01130 SRSF2	1	SRSF2 [nucleoplasm] (R-HSA-72033)	0.597	4
UniProt:P21333 FLNA	3	FLNA [extracellular region] (R-HSA-350712) p-S2152-FLNA [cytosol] (R-HSA-5669246) FLNA [cytosol] (R-HSA-210019)	0.597	3
UniProt:P35579 MYH9	3	MYH9 [cytosol] (R-HSA-419173) MYH9(2-1644)-ALK(1067-1620) fusion [cytosol] (R-HSA-9715280) MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol] (R-HSA-9715279)	0.597	3
UniProt:P06396 GSN	7	GSN(200-270) [extracellular region] (R-HSA-976940) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.597	3
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.597	3
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.597	4
UniProt:Q92841 DDX17	2	DDX17 [nucleoplasm] (R-HSA-3900090) monoSUMO1-K50-DDX17 [nucleoplasm] (R-HSA-3900104)	0.597	3
UniProt:Q8IZL8 PELP1	1	PELP1 [nucleoplasm] (R-HSA-3826531)	0.597	3
UniProt:P10276 RARA	3	SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) RARA [nucleoplasm] (R-HSA-446164)	0.597	4
UniProt:P06401-1 PGR			0.593	4
UniProt:Q12802 AKAP13	1	AKAP13 [cytosol] (R-HSA-2975983)	0.593	3
UniProt:Q9Y6C7 L3R2A			0.593	3
UniProt:O60869 EDF1			0.59	3
UniProt:P17676 CEBPB	3	p-T235, S321-CEBPB [nucleoplasm] (R-HSA-3857339) p-T235-CEBPB [nucleoplasm] (R-HSA-3857343) CEBPB [nucleoplasm] (R-HSA-381378)	0.59	2
UniProt:P18846 ATF1	2	ATF1 [nucleoplasm] (R-HSA-199900) p-S63-ATF1 [nucleoplasm] (R-HSA-199897)	0.59	3
UniProt:Q15596 NCOA2	3	monoSUMO1-K239,K731,K788-NCOA2 [nucleoplasm] (R-HSA-4085305) NCOA2 (869-1464) [nucleoplasm] (R-HSA-5603186) NCOA2 [nucleoplasm] (R-HSA-376398)	0.584	5
UniProt:O43251 RBFOX2	1	RBFOX2 [nucleoplasm] (R-HSA-6803504)	0.581	4
UniProt:Q96AQ6-1 PBXIP1			0.576	3
IntAct:EBI-10099285 VITA2			0.576	5
UniProt:Q86Y37 CACL1			0.571	5
UniProt:Q9UHF7 TRPS1			0.564	4
UniProt:P48552 NRIP1	2	monoSUMO1-K756,K1154-NRIP1 [nucleoplasm] (R-HSA-4086057) NRIP1 [nucleoplasm] (R-HSA-4086031)	0.564	3
UniProt:P36873 PPP1CC	1	PPP1CC [cytosol] (R-HSA-163443)	0.564	3
UniProt:Q15648 MED1	1	MED1 [nucleoplasm] (R-HSA-212445)	0.564	3
UniProt:P00523 SRC	9	SRC [cytosol] (R-GGA-9628701) phospho-p-Y419-SRC [cytosol] (R-GGA-8964276) Src [cytosol] (R-GGA-3928468) MyrG-SRC [plasma membrane] (R-GGA-8876922) phospho-p-Y419-SRC [cytosol] (R-GGA-377592) phospho-MyrG,p-Y530-SRC [plasma membrane] (R-GGA-377598) SRC-1 [plasma membrane] (R-GGA-65043) phospho-MyrG-p-Y419-SRC [plasma membrane] (R-GGA-1810408) SRC-2 [cytosol] (R-GGA-191648)	0.564	2
UniProt:P08047 SP1	1	SP1 [nucleoplasm] (R-HSA-1592223)	0.558	2
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q6ZQX7-4 Q6ZQX74			0.556	3
UniProt:Q16881-4 TXNRD1			0.556	4
UniProt:Q6XD76 ASCL4			0.556	3
UniProt:P62962 Pfn1	2	Profilin-1 [extracellular region] (R-MMU-350698) Pfn1 [cytosol] (R-MMU-350757)	0.556	3
UniProt:Q9UBK2 PPARGC1A	4	monoSUMO1-K184-PPARGC1A [nucleoplasm] (R-HSA-3903023) p-T263,S266,T299-PPARGC1A [nucleoplasm] (R-HSA-1592224) p-T178,S539-PPARGC1A [nucleoplasm] (R-HSA-1592204) PPARGC1A [nucleoplasm] (R-HSA-442481)	0.553	2
UniProt:Q9BZ95 NSD3	1	WHSC1L1 [nucleoplasm] (R-HSA-1183230)	0.547	3
IntAct:EBI-2695616 ERE			0.544	2
UniProt:Q96Q04 LMTK3			0.544	3
UniProt:Q14151 SAFB2			0.544	2
UniProt:Q09472 EP300	5	monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.536	2
UniProt:Q92731 ESR2	5	PalmS-ESR2 [cytosol] (R-HSA-9020979) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) PalmS-ESR2 [plasma membrane] (R-HSA-9021059) ESR2 [nucleoplasm] (R-HSA-446165) ESR2 [cytosol] (R-HSA-9020970)	0.532	3
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.532	3
UniProt:P82673 MRPS35	1	MRPS35 [mitochondrial inner membrane] (R-HSA-5368185)	0.527	3
UniProt:P62269 RPS18	2	RPS18 [nucleoplasm] (R-HSA-6798701) RPS18 [cytosol] (R-HSA-72341)	0.527	2
UniProt:Q99832 CCT7	1	CCT7 [cytosol] (R-HSA-390451)	0.527	2
UniProt:P68363 TUBA1B	9	AcK-TUBA1B [cytosol] (R-HSA-5618285) Ac K40 TUBA1B [axonemal microtubule] (R-HSA-5624854) TUBA1B folding intermediate [cytosol] (R-HSA-392797) TUBA1B unfolded [cytosol] (R-HSA-392781) L-isoglutamyl polyglycyl-TUBA1B [cytosol] (R-HSA-8867436) Polyglutamyl-TUBA1B [cytosol] (R-HSA-8867435) TUBA1B(1-450) [cytosol] (R-HSA-8955581) TUBA1B [axonemal microtubule] (R-HSA-5610434) TUBA1B [cytosol] (R-HSA-191691)	0.527	3
UniProt:P05109 S100A8	3	S100A8 [secretory granule lumen] (R-HSA-6804772) S100A8 [cytosol] (R-HSA-9626834) S100A8 [extracellular region] (R-HSA-5432846)	0.527	2
UniProt:Q96SB4 SRPK1	2	SRPK1 [nucleoplasm] (R-HSA-9821984) SRPK1 [cytosol] (R-HSA-9729349)	0.527	3
UniProt:Q9HCM4 EPB41L5	1	EPB41L5 [cytosol] (R-HSA-6797564)	0.527	3
UniProt:Q9NX58 LYAR			0.527	3
UniProt:Q8NI36 WDR36	1	WDR36 [nucleoplasm] (R-HSA-6790623)	0.527	3
UniProt:O00165 HAX1			0.527	2
IntAct:EBI-1265559 MYC			0.527	3
UniProt:Q13823 NOG2			0.527	3
UniProt:P08865 RPSA	2	RPSA [nucleoplasm] (R-HSA-6798722) RPSA [cytosol] (R-HSA-72389)	0.527	3
UniProt:Q9NSY1 BMP2K			0.527	3
UniProt:Q9UPN3 MACF1			0.527	3
UniProt:Q14684 RRP1B			0.527	3
UniProt:P60866 RPS20	2	RPS20 [nucleoplasm] (R-HSA-6798727) RPS20 [cytosol] (R-HSA-72349)	0.527	2
UniProt:Q9NPD3 EXOSC4	2	EXOSC4 [nucleoplasm] (R-HSA-6791503) EXOSC4 [cytosol] (R-HSA-430013)	0.527	3
UniProt:Q7Z406 MYH14	1	MYH14 [cytosol] (R-HSA-419176)	0.527	2
UniProt:O95793 STAU1			0.527	2
UniProt:Q9BY89 K1671			0.527	3
UniProt:Q5M775 CYTSB			0.527	3
UniProt:P27708 CAD	1	CAD [cytosol] (R-HSA-73452)	0.527	3
UniProt:Q9Y399 MRPS2	2	MRPS2 [mitochondrial matrix] (R-HSA-9839682) MRPS2 [mitochondrial inner membrane] (R-HSA-8866677)	0.527	3
UniProt:Q15084 PDIA6	3	PDIA6 [endoplasmic reticulum membrane] (R-HSA-535530) p-PDIA6 [endoplasmic reticulum lumen] (R-HSA-8957031) PDIA6 [endoplasmic reticulum lumen] (R-HSA-3009049)	0.527	3
UniProt:P07205 PGK2	1	PGK2 [cytosol] (R-HSA-6807622)	0.527	2
UniProt:Q9BUF5 TUBB6	6	TUBB6 [cytosol] (R-HSA-191698) TUBB6 [axonemal microtubule] (R-HSA-5610438) Polyglutamyl-TUBB6 [cytosol] (R-HSA-8867399) Polyglycyl-TUBB6 [cytosol] (R-HSA-8867396) TUBB6 unfolded [cytosol] (R-HSA-392780) TUBB6 folding intermediate [cytosol] (R-HSA-392787)	0.527	3
UniProt:P56192 MARS1	1	MARS [cytosol] (R-HSA-379657)	0.527	3
UniProt:O75146 HIP1R	3	HIP1R [cytosol] (R-HSA-8868155) HIP1R [Golgi membrane] (R-HSA-434348) HIP1R [cytoplasmic vesicle membrane] (R-HSA-434201)	0.527	3
UniProt:P46940 IQGAP1	3	IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [plasma membrane] (R-HSA-381681)	0.527	3
UniProt:O60784 TOM1	3	TOM1 [azurophil granule membrane] (R-HSA-6799348) TOM1 [plasma membrane] (R-HSA-6806274) TOM1 [specific granule membrane] (R-HSA-6800923)	0.527	3
UniProt:O75110 ATP9A	1	ATP9A [plasma membrane] (R-HSA-939754)	0.527	3
UniProt:P28290 ITPI2			0.527	3
UniProt:P82650 MRPS22	1	MRPS22 [mitochondrial inner membrane] (R-HSA-5368259)	0.527	3
UniProt:P12268 IMPDH2	4	IMPDH2 [secretory granule lumen] (R-HSA-6803323) IMPDH2 [extracellular region] (R-HSA-6806455) IMPDH2 [ficolin-1-rich granule lumen] (R-HSA-6803330) IMPDH2 [cytosol] (R-HSA-57350)	0.527	3
UniProt:Q92665 MRPS31	1	MRPS31 [mitochondrial inner membrane] (R-HSA-5368198)	0.527	3
UniProt:O43432 EIF4G3	1	EIF4G3 [cytosol] (R-HSA-1678827)	0.527	3
UniProt:Q96EY7 PTCD3	1	PTCD3 [mitochondrial inner membrane] (R-HSA-5368165)	0.527	3
UniProt:Q8IYT4 KATL2			0.527	2
UniProt:P53680 AP2S1	4	AP2S1 [cytosol] (R-HSA-182197) AP2S1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130707) AP2S1 [plasma membrane] (R-HSA-389382) AP2S1 [endolysosome membrane] (R-HSA-6784821)	0.527	3
UniProt:Q9UBF2 COPG2	4	COPG2 [endoplasmic reticulum membrane] (R-HSA-6810962) COPG2 [Golgi membrane] (R-HSA-6808751) COPG2 [transport vesicle] (R-HSA-6808753) COPG2 [cytosol] (R-HSA-6807747)	0.527	3
UniProt:P62158 CALM			0.527	3
UniProt:Q92552 MRPS27	1	MRPS27 [mitochondrial inner membrane] (R-HSA-5368214)	0.527	3
UniProt:P62952 BLCAP			0.527	2
UniProt:O60568 PLOD3	1	PLOD3 [endoplasmic reticulum membrane] (R-HSA-1981135)	0.527	2
UniProt:Q9Y4P3 TBL2			0.527	3
UniProt:Q9NQZ2 UTP3	1	UTP3 [nucleoplasm] (R-HSA-6790637)	0.527	3
UniProt:P32455 GBP1	1	GBP1 [cytosol] (R-HSA-1031698)	0.527	2
UniProt:Q9BRD0 BUD13	1	BUD13 [nucleoplasm] (R-HSA-9769522)	0.527	3
UniProt:Q9UN36 NDRG2			0.527	2
UniProt:Q7Z2W4 ZC3HAV1	2	ZC3HAV1(2-624)-BRAF(439-766) fusion [cytosol] (R-HSA-6802506) ZC3HAV1(2-624)-p-BRAF(439-766) fusion [cytosol] (R-HSA-6802557)	0.527	3
UniProt:O43175 PHGDH	1	PHGDH [cytosol] (R-HSA-977340)	0.527	3
UniProt:P05089 ARG1	4	ARG1 [specific granule lumen] (R-HSA-6801011) ARG1 [extracellular region] (R-HSA-6806221) ARG1 [azurophil granule lumen] (R-HSA-6798764) ARG1 [cytosol] (R-HSA-70561)	0.527	2
UniProt:Q8WUY1 THEM6			0.527	3
UniProt:Q9Y2R5 MRPS17	1