Reactome | ESR1 [nucleoplasm]

ESR1 [nucleoplasm]

Stable Identifier

R-HSA-446168

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Estrogen receptor, ESR1_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:P62424 RPL7A

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External Reference Information

External Reference

UniProt:P03372 ESR1

Gene Names

ESR1, ESR, NR3A1

Chain

chain:1-595

Reference Genes

BioGPS Gene:2099 ESR1

COSMIC (genes):ESR1 ESR1

CTD Gene:2099 ESR1

dbSNP Gene:2099 ESR1

ENSEMBL:ENSG00000091831 ESR1

HGNC:3467 ESR1

KEGG:hsa:2099 ESR1

Monarch:2099 ESR1

NCBI Gene:2099 ESR1

OMIM:133430 ESR1

UCSC:P03372 ESR1

Reference Transcript

Participates

as a component of

as a member of

as an input of

as a protein marker of

as an output of

TFAP2A,TFAP2C homodimers stimulate ESR1 gene expression (Homo sapiens)

Other forms of this molecule

ESR1 [cytosol]

PalmS-ESR1 [cytosol]

PalmS-ESR1 [plasma membrane]

Me260-PalmS-ESR1 [plasma membrane]

Me260-ESR1 [cytosol]

p-S167-ESR1 [cytosol]

p-S167-ESR1 [nucleoplasm]

monoSUMO1-5K-ESR1 [nucleoplasm]

p-S118-ESR1 [nucleoplasm]

Inferred To

Ghost homologue of ESR1 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of ESR1 [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of ESR1 [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of ESR1 [nucleoplasm] (Schizosaccharomyces pombe)

knrl [nucleoplasm] (Drosophila melanogaster)

ESR1 [nucleoplasm] (Bos taurus)

ESR1 [nucleoplasm] (Canis familiaris)

ESR1 [nucleoplasm] (Gallus gallus)

ESR1 [nucleoplasm] (Sus scrofa)

esr1 [nucleoplasm] (Danio rerio)

esr1 [nucleoplasm] (Xenopus tropicalis)

ERR [nucleoplasm] (Drosophila melanogaster)

kni [nucleoplasm] (Drosophila melanogaster)

Esr1 [nucleoplasm] (Mus musculus)

Esr1 [nucleoplasm] (Rattus norvegicus)

Homologues of ESR1 [nucleoplasm] (Drosophila melanogaster)

eg [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

XP_054210455.1, XP_054210453.1, XP_011533845.1, XP_011533847.1, XP_011533846.1, XP_054210454.1, XP_054210451.1, NP_001372497.1, NP_001372498.1, XP_054210450.1, XP_054210452.1, NP_001315029.1, XP_016865870.1, XP_047274245.1, XP_054210447.1, XP_054210449.1, XP_054210448.1, NP_001278170.1, XP_047274246.1, NP_000116.2, XP_006715438.1, XP_016865865.1, NP_001116214.1, NP_001116212.1, XP_016865869.1, XP_016865866.1, NP_001116213.1, NP_001278159.1, XP_016865868.1, XP_016865867.1

ZINC - World Drugs

ESR1_HUMAN

Guide to Pharmacology - Targets

620

OpenTargets

ENSG00000091831

ENSEMBL

ENST00000427531, ENST00000443427, ENST00000206249, ENSP00000342630, ENSG00000091831, ENST00000440973, ENSP00000206249, ENSP00000394721, ENSP00000405330, ENST00000338799, ENSP00000387500

ZINC - FDA approved

ESR1_HUMAN

ZINC - Substances

ESR1_HUMAN

ZINC - Biogenic

ESR1_HUMAN

ZINC target

P03372

PRO

P03372

GlyGen

P03372

PDB

5DXK, 8AM7, 7SFO, 5E0X, 5TN7, 4DMA, 6VGH, 9BPX, 5TN5, 8C4F, 4PPP, 5TLO, 5FQT, 5KRH, 4IVY, 8BY9, 8BZF, 8DU8, 3HLV, 5TLL, 8ARQ, 3OSA, 5DUE, 8B39, 8BX3, 5AAU, 7NIZ, 8ALT, 4IWF, 8AXU, 7UJ7, 5E19, 6B0F, 7R62, 4ZN9, 2B1Z, 6SQ0, 3UU7, 6VJD, 8BZG, 2G44, 8VYX, 8ARR, 8DU6, 1X7R, 5DX3, 5GS4, 4Q13, 6CBZ, 4MG6, 9BU1, 8EV1, 8AU2, 5KCU, 5KRK, 2QSE, 8BZW, 5DXM, 2YAT, 5TN9, 4MG8, 5DMC, 5FQV, 4PPS, 5DTV, 2OUZ, 8VZP, 8ALW, 8BXI, 8ARW, 8BYG, 4IW6, 8BZD, 2OCF, 6PSJ, 7RRY, 5DLR, 5DKS, 5AK2, 4MG7, 8ATP, 8EV2, 5KRJ, 5KD9, 5E14, 6ZOR, 8ALR, 7Y8F, 5TLV, 4MG9, 5T92, 5TM3, 5DWI, 5DXP, 5TMZ, 8VZQ, 8AWG, 4IVW, 1X7E, 5TLD, 8BZE, 1HCQ, 2FAI, 8AOY, 7RRZ, 8AR4, 5DL4, 2IOG, 2QGW, 5KCW, 8ARX, 8AUY, 3Q95, 8C04, 5E15, 7MSA, 8AQ1, 5TM7, 7Y8G, 5DRM, 2B1V, 5TM2, 7NDO, 7UJ8, 1ERR, 5DKE, 8BXQ, 8ARO, 8VZ0, 7N9O, 2Q70, 1GWR, 7RS8, 1HCP, 6HKB, 4IW8, 4ZNS, 1XP6, 8BWZ, 5DVS, 8C42, 5TMO, 8BZT, 8AFN, 5E0W, 5DMF, 5DZH, 4ZNT, 6IAR, 5W9D, 3OS8, 2JFA, 5TLT, 7QVL, 6CHW, 6DFN, 5E1C, 8AS1, 8BX0, 7BAA, 8VZ1, 8BYY, 7RRX, 5DVV, 2QH6, 8C0K, 5EGV, 8BXM, 1PCG, 6TJM, 6VPF, 5T97, 5TLU, 7KBS, 6HMU, 5DRJ, 4ZNU, 2B23, 8DUS, 5W9C, 5U2B, 5TM5, 5DIE, 7QVJ, 8APS, 2QXS, 6ZOQ, 4AA6, 5KRM, 8BXN, 3OS9, 8BYZ, 7RS9, 6PFM, 8C0L, 5DKG, 7PWZ, 5KCT, 5DZI, 5TMQ, 5DI7, 4ZNV, 2QR9, 5T0X, 2QAB, 2QA8, 8DV5, 4Q50, 5U2D, 5DU5, 5TM4, 1R5K, 5TM6, 5DID, 8AT9, 4JDD, 5TMM, 5KRA, 8DUC, 1GWQ, 5DXB, 5KRL, 8ANF, 5DWJ, 8BZ9, 1XP1, 7RS2, 2QGT, 7TE7, 2AYR, 1UOM, 6DF6, 5TN1, 7UJW, 4MG5, 8AR5, 7RNM, 6CHZ, 3HM1, 4ZN7, 8W03, 5KCD, 5TLX, 7UJF, 6PET, 5KRO, 6OWC, 8BXO, 5DIG, 5UFW, 6HKF, 5N10, 4O6F, 2QZO, 7RS3, 7BAB, 6CZN, 2P15, 7OQ7, 4ZNW, 7WNV, 5DYB, 5TML, 5DK9, 8BYO, 8DVB, 1YIN, 2POG, 5WGQ, 5TMS, 5KCC, 5TM9, 8BYB, 7BA8, 7NEL, 5ACC, 5EI1, 8DV8, 7RS0, 5DZ3, 2LLQ, 8DUD, 8AV3, 8BXS, 2BJ4, 5GTR, 5DP0, 8ARG, 3DT3, 4IV4, 7BA5, 2QA6, 8BZ0, 5HYR, 7JHD, 1YIM, 5DYD, 5TN4, 7RKE, 5TM8, 8DUB, 5UFX, 7BA9, 1ERE, 8BZH, 1L2I, 4XI3, 4IV2, 7RS1, 2LLO, 6C42, 8BX4, 7UJY, 4TV1, 7OPW, 1SJ0, 5DUG, 7RS7, 8AZE, 6HHP, 3UUC, 5TLY, 2QE4, 2JF9, 5TMR, 5TNB, 8W07, 7BA3, 5T1Z, 7BA6, 1QKU, 5DXE, 8DV7, 8AV7, 3CBM, 6V8T, 8BZB, 7NFW, 2IOK, 4ZNH, 8DUG, 7PWT, 7B9R, 5KR9, 7OQ8, 7RS4, 7UJO, 3ERT, 3UUD, 4MGA, 4PP6, 7NFB, 3UUA, 5EIT, 8DUK, 5TN3, 6D0F, 7UJC, 1QKT, 7BA7, 8AV8, 2R6Y, 8BZC, 8VYT, 5DZ0, 5WGD, 8AUS, 8BYE, 8DUH, 2YJA, 5TMW, 5DXR, 5FQP, 5TLM, 9BQE, 5KCF, 1A52, 5DUH, 4MGB, 4JC3, 4IU7, 8DUI, 8AQC, 5TMU, 8ARY, 4PXM, 8BWX, 2R6W, 3CBO, 5TLF, 5EHJ, 4IUI, 5DZ1, 8BYF, 3L03, 5DKB, 8AV4, 6V87, 5TN8, 6PIT, 4MGC, 7B9M, 6ZOS, 5DXQ, 5KCE, 7UJM, 5DWE, 1XPC, 1ZKY, 2I0J, 8C4G, 5FQS, 5TLP, 5TN6, 8ARZ, 5TLG, 4TUZ, 5KRF, 6SUO, 8DU9, 8BZA, 1XP9, 6SBO, 1G50, 4IWC, 8BYC, 5KRC, 5DXG, 5TMV, 8ALV, 8BWJ, 2QXM, 4MGD, 3ERD, 5DWG, 6TL3, 7T2X, 2Q6J, 8AQE, 5FQR, 5TM1, 5DY8, 2G5O, 5TMT, 5KRI, 3CBP, 6WOK, 8AXE, 8AI0, 8AQZ, 7YMK, 7B9T, 8BYD, 5AAV, 1XQC, 5JMM

ZINC - Investigational

ESR1_HUMAN

ZINC - Metabolites

ESR1_HUMAN

GeneCards

ESR1

HPA

ENSG00000091831-ESR1

Pharos - Targets

P03372

Orphanet

ESR1

ZINC - Predictions - Purchasable

ESR1_HUMAN

HMDB Protein

HMDBP02078

Interactors (273)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.87	11
UniProt:P12931 SRC	6	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276)	0.848	12
UniProt:Q15788 NCOA1	3	NCOA1 [nucleoplasm] (R-HSA-442496) NCOA1 (868-1441) [nucleoplasm] (R-HSA-5603230) monoSUMO1-K732,K774-NCOA1 [nucleoplasm] (R-HSA-4085291)	0.835	8
UniProt:Q04206 RELA	7	RELA [nucleoplasm] (R-HSA-177676) RELA [cytosol] (R-HSA-168172) p-S276-RELA [nucleoplasm] (R-HSA-5624468) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S536-RELA [nucleoplasm] (R-HSA-9861499) MeK310-RELA [nucleoplasm] (R-HSA-8865233)	0.832	9
UniProt:P38398 BRCA1	20	polySUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) monoSUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) BRCA1 M1411T [nucleoplasm] (R-HSA-9702140) BRCA1 M1400V [nucleoplasm] (R-HSA-9701202) BRCA1 L1407P [nucleoplasm] (R-HSA-9702135) BRCA1 Y777* [nucleoplasm] (R-HSA-9702765) BRCA1 S1009* [nucleoplasm] (R-HSA-9702755) BRCA1 P724Lfs12 [nucleoplasm] (R-HSA-9703778) BRCA1 S451 [nucleoplasm] (R-HSA-9702754) BRCA1 S864* [nucleoplasm] (R-HSA-9702752) BRCA1 P897Kfs5 [nucleoplasm] (R-HSA-9703782) BRCA1 N555Kfs17 [nucleoplasm] (R-HSA-9703781) BRCA1 Y1127Sfs6 [nucleoplasm] (R-HSA-9703780) BRCA1 S886Cfs16 [nucleoplasm] (R-HSA-9703802) BRCA1 V83Cfs2 [nucleoplasm] (R-HSA-9703800) BRCA1 T464Pfs11 [nucleoplasm] (R-HSA-9703807) BRCA1 G813Dfs2 [nucleoplasm] (R-HSA-9703549) BRCA1 V340Gfs6 [nucleoplasm] (R-HSA-9703804) BRCA1 Y655* [nucleoplasm] (R-HSA-9702769) BRCA1 W372* [nucleoplasm] (R-HSA-9702768)	0.811	16
IntAct:EBI-5590876 TFF1			0.788	6
UniProt:P06401 PGR	3	PGR [nucleoplasm] (R-HSA-3008952) PGR [cytosol] (R-HSA-8948964) monoSUMO1-K7,K388,K531-PGR [nucleoplasm] (R-HSA-4341032)	0.774	20
UniProt:P55345 ANM2			0.75	9
UniProt:Q6PL18 ATAD2	1	ATAD2 [nucleoplasm] (R-HSA-8937250)	0.737	5
UniProt:Q9H1R3 MYLK2			0.725	5
UniProt:P60709 ACTB	5	ACTB [plasma membrane] (R-HSA-196016) ACTB [lysosomal membrane] (R-HSA-196160) ACTB [cytosol] (R-HSA-201861) ACTB [nucleoplasm] (R-HSA-3321990) Unfolded ACTB [cytosol] (R-HSA-390462)	0.723	6
UniProt:P62701 RPS4X	2	RPS4X [cytosol] (R-HSA-72375) RPS4X [nucleoplasm] (R-HSA-6798713)	0.69	4
UniProt:P05388 RPLP0	1	RPLP0 [cytosol] (R-HSA-72396)	0.69	4
UniProt:P62854 RPS26	2	RPS26 [cytosol] (R-HSA-72359) RPS26 [nucleoplasm] (R-HSA-6798708)	0.69	5
UniProt:Q969Q0 RPL36AL	1	RPL36AL [cytosol] (R-HSA-8868805)	0.69	5
UniProt:Q9BQ69 MACD1			0.69	6
UniProt:Q9Y6Q9 NCOA3	2	NCOA3 [nucleoplasm] (R-HSA-442488) p-S857 NCOA3 [nucleoplasm] (R-HSA-5687005)	0.688	4
UniProt:P29279 CCN2	1	CTGF [extracellular region] (R-HSA-561148)	0.682	7
UniProt:P19838-PRO_0000030311 NFKB1			0.676	3
UniProt:Q02447 SP3	3	monoSUMO1-K551-SP3 [nucleoplasm] (R-HSA-3247472) polySUMO2-K551-SP3 [nucleoplasm] (R-HSA-6804456) SP3 [nucleoplasm] (R-HSA-2160951)	0.667	4
UniProt:Q6NYC1 JMJD6	1	JMJD6 [nucleoplasm] (R-HSA-4754226)	0.649	8
UniProt:Q9Y294 ASF1A	1	ASF1A [nucleoplasm] (R-HSA-417169)	0.647	4
UniProt:P06576 ATP5F1B	6	ATP5B(1-529) [cytosol] (R-HSA-1267973) ATP5B(1-529) [mitochondrial intermembrane space] (R-HSA-1267985) ATP5B(1-529) [mitochondrial inner membrane] (R-HSA-1299440) ATP5B(1-47) [mitochondrial matrix] (R-HSA-8986172) ATP5B [mitochondrial inner membrane] (R-HSA-1299441) ATP5F1B [mitochondrial matrix] (R-HSA-164576)	0.643	4
UniProt:P17844 DDX5	4	DDX5 [nucleoplasm] (R-HSA-3900136) DDX5 [cytosol] (R-HSA-9682643) polySUMO2-K53-DDX5 [nucleoplasm] (R-HSA-3900186) monoSUMO1-K53-DDX5 [nucleoplasm] (R-HSA-3900041)	0.643	4
UniProt:P60660 MYL6	2	p-S20-MYL6 [cytosol] (R-HSA-445778) MYL6 [cytosol] (R-HSA-419186)	0.642	3
UniProt:O15164 TRIM24	4	TRIM24(1-510)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802555) TRIM24(1-510)-BRAF(381-766) fusion [cytosol] (R-HSA-6802477) TRIM24(1-626)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1839012) TRIM24(1-626)-FGFR1(429-822) fusion [cytosol] (R-HSA-1614442)	0.641	3
UniProt:P60763 RAC3	3	RAC3 [endoplasmic reticulum membrane] (R-HSA-9714693) RAC3 [plasma membrane] (R-HSA-195338) RAC3 [cytosol] (R-HSA-195335)	0.639	5
UniProt:Q8N895 ZN366			0.633	6
UniProt:O43524 FOXO3	11	FOXO3 [nucleoplasm] (R-HSA-199305) p-T32,S253,S315-FOXO3 [nucleoplasm] (R-HSA-199289) p-T32,S253,S315-FOXO3 [cytosol] (R-HSA-9614413) Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] (R-HSA-9620514) Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841849) FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841824) p-S43,S173,S294,S325-FOXO3 [cytosol] (R-HSA-8870560) p-S43,S173,S294,S325-FOXO3 [nucleoplasm] (R-HSA-8870627) FOXO3 [cytosol] (R-HSA-5687032) p-S215 FOXO3 [cytosol] (R-HSA-5687014) p-S215 FOXO3 [nucleoplasm] (R-HSA-5687010)	0.632	7
UniProt:Q03989 ARI5A			0.625	9
UniProt:P53041 PPP5C	2	PPP5C [nucleoplasm] (R-HSA-5683410) PPP5C [cytosol] (R-HSA-5675402)	0.625	4
UniProt:P23771 GATA3	2	GATA3 [nucleoplasm] (R-HSA-996768) PolyUb-GATA3 [nucleoplasm] (R-HSA-6783009)	0.623	4
UniProt:P05627 Jun	5	p-S63,S73-Jun [cytosol] (R-MMU-8868678) Jun [cytosol] (R-MMU-8868685) Jun [nucleoplasm] (R-MMU-3261183) phospho-Jun [nucleoplasm] (R-MMU-450237) Jun [nucleoplasm] (R-MMU-450250)	0.616	6
UniProt:Q9Y3R0 GRIP1	2	GRIP1 [plasma membrane] (R-HSA-416638) GRIP1 [cytosol] (R-HSA-416633)	0.609	2
UniProt:P62263 RPS14	2	RPS14 [cytosol] (R-HSA-72333) RPS14 [nucleoplasm] (R-HSA-6790669)	0.597	3
UniProt:P35579 MYH9	3	MYH9 [cytosol] (R-HSA-419173) MYH9(2-1644)-ALK(1067-1620) fusion [cytosol] (R-HSA-9715280) MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol] (R-HSA-9715279)	0.597	3
UniProt:Q5JTH9 RRP12			0.597	4
UniProt:P10276 RARA	3	RARA [nucleoplasm] (R-HSA-446164) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830)	0.597	4
UniProt:Q00610 CLTC	10	CLTC [plasma membrane] (R-HSA-2980668) CLTC [lysosomal membrane] (R-HSA-2980660) CLTC [clathrin-coated endocytic vesicle membrane] (R-HSA-5138450) CLTC [endolysosome membrane] (R-HSA-8870827) CLTC [cytosol] (R-HSA-8856820) CLTC(2-1634)insV-ALK(1059-1620) fusion [cytosol] (R-HSA-9710853) CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9710835) CLTC(2-1634)insV-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9710854) CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-ALK(1058-1620) fusion [cytosol] (R-HSA-9710852) CLTC [trans-Golgi network membrane] (R-HSA-5333703)	0.597	3
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.597	3
UniProt:Q01130 SRSF2	1	SRSF2 [nucleoplasm] (R-HSA-72033)	0.597	4
UniProt:P61513 RPL37A	1	RPL37A [cytosol] (R-HSA-72468)	0.597	4
UniProt:P27635 RPL10	1	RPL10 [cytosol] (R-HSA-72402)	0.597	4
UniProt:P06396 GSN	7	GSN [cytosol] (R-HSA-350275) GSN(28-403) [cytosol] (R-HSA-201618) GSN(404-782) [cytosol] (R-HSA-350272) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(200-270) [extracellular region] (R-HSA-976940)	0.597	3
UniProt:Q8IZL8 PELP1	1	PELP1 [nucleoplasm] (R-HSA-3826531)	0.597	3
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.597	4
UniProt:P21333 FLNA	3	FLNA [cytosol] (R-HSA-210019) p-S2152-FLNA [cytosol] (R-HSA-5669246) FLNA [extracellular region] (R-HSA-350712)	0.597	3
UniProt:Q96GQ7 DDX27			0.597	4
UniProt:Q92841 DDX17	2	DDX17 [nucleoplasm] (R-HSA-3900090) monoSUMO1-K50-DDX17 [nucleoplasm] (R-HSA-3900104)	0.597	3
UniProt:Q9BVP2 GNL3	1	GNL3 [nucleoplasm] (R-HSA-8869324)	0.597	4
UniProt:O43823 AKAP8			0.597	4
UniProt:P06401-1 PGR			0.593	4
UniProt:Q12802 AKAP13	1	AKAP13 [cytosol] (R-HSA-2975983)	0.593	3
UniProt:Q9Y6C7 L3R2A			0.593	3
UniProt:O60869 EDF1			0.59	3
UniProt:P18846 ATF1	2	ATF1 [nucleoplasm] (R-HSA-199900) p-S63-ATF1 [nucleoplasm] (R-HSA-199897)	0.59	3
UniProt:P17676 CEBPB	3	p-T235, S321-CEBPB [nucleoplasm] (R-HSA-3857339) p-T235-CEBPB [nucleoplasm] (R-HSA-3857343) CEBPB [nucleoplasm] (R-HSA-381378)	0.59	2
UniProt:Q15596 NCOA2	3	NCOA2 [nucleoplasm] (R-HSA-376398) NCOA2 (869-1464) [nucleoplasm] (R-HSA-5603186) monoSUMO1-K239,K731,K788-NCOA2 [nucleoplasm] (R-HSA-4085305)	0.584	5
UniProt:O43251 RBFOX2	1	RBFOX2 [nucleoplasm] (R-HSA-6803504)	0.581	4
UniProt:Q96AQ6-1 PBXIP1			0.576	3
IntAct:EBI-10099285 VITA2			0.576	5
UniProt:Q86Y37 CACL1			0.571	5
UniProt:P36873 PPP1CC	1	PPP1CC [cytosol] (R-HSA-163443)	0.564	3
UniProt:P48552 NRIP1	2	NRIP1 [nucleoplasm] (R-HSA-4086031) monoSUMO1-K756,K1154-NRIP1 [nucleoplasm] (R-HSA-4086057)	0.564	3
UniProt:Q15648 MED1	1	MED1 [nucleoplasm] (R-HSA-212445)	0.564	3
UniProt:Q9UHF7 TRPS1			0.564	4
UniProt:P00523 SRC	1	Src [cytosol] (R-GGA-3928468)	0.564	2
UniProt:P08047 SP1	1	SP1 [nucleoplasm] (R-HSA-1592223)	0.558	2
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q6ZQX7-4 Q6ZQX74			0.556	3
UniProt:Q16881-4 TXNRD1			0.556	4
UniProt:Q6XD76 ASCL4			0.556	3
UniProt:P62962 Pfn1	2	Profilin-1 [extracellular region] (R-MMU-350698) Pfn1 [cytosol] (R-MMU-350757)	0.556	3
UniProt:Q9UBK2 PPARGC1A	4	PPARGC1A [nucleoplasm] (R-HSA-442481) p-T178,S539-PPARGC1A [nucleoplasm] (R-HSA-1592204) p-T263,S266,T299-PPARGC1A [nucleoplasm] (R-HSA-1592224) monoSUMO1-K184-PPARGC1A [nucleoplasm] (R-HSA-3903023)	0.553	2
UniProt:Q9BZ95 NSD3	1	WHSC1L1 [nucleoplasm] (R-HSA-1183230)	0.547	3
IntAct:EBI-2695616 ERE			0.544	2
UniProt:Q96Q04 LMTK3			0.544	3
UniProt:Q14151 SAFB2			0.544	2
UniProt:P00533 EGFR	20	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334)	0.536	3
UniProt:Q09472 EP300	5	EP300 [nucleoplasm] (R-HSA-381325) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306)	0.536	2
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.532	3
UniProt:Q92731 ESR2	5	ESR2 [cytosol] (R-HSA-9020970) ESR2 [nucleoplasm] (R-HSA-446165) PalmS-ESR2 [cytosol] (R-HSA-9020979) PalmS-ESR2 [plasma membrane] (R-HSA-9021059) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787)	0.532	3
UniProt:P82673 MRPS35	1	MRPS35 [mitochondrial inner membrane] (R-HSA-5368185)	0.527	3
UniProt:P62269 RPS18	2	RPS18 [cytosol] (R-HSA-72341) RPS18 [nucleoplasm] (R-HSA-6798701)	0.527	2
UniProt:Q99832 CCT7	1	CCT7 [cytosol] (R-HSA-390451)	0.527	2
UniProt:P68363 TUBA1B	9	TUBA1B [cytosol] (R-HSA-191691) TUBA1B [axonemal microtubule] (R-HSA-5610434) TUBA1B(1-450) [cytosol] (R-HSA-8955581) Polyglutamyl-TUBA1B [cytosol] (R-HSA-8867435) L-isoglutamyl polyglycyl-TUBA1B [cytosol] (R-HSA-8867436) TUBA1B unfolded [cytosol] (R-HSA-392781) TUBA1B folding intermediate [cytosol] (R-HSA-392797) Ac K40 TUBA1B [axonemal microtubule] (R-HSA-5624854) AcK-TUBA1B [cytosol] (R-HSA-5618285)	0.527	3
UniProt:P05109 S100A8	3	S100A8 [extracellular region] (R-HSA-5432846) S100A8 [secretory granule lumen] (R-HSA-6804772) S100A8 [cytosol] (R-HSA-9626834)	0.527	2
UniProt:Q96SB4 SRPK1	2	SRPK1 [cytosol] (R-HSA-9729349) SRPK1 [nucleoplasm] (R-HSA-9821984)	0.527	3
UniProt:Q9HCM4 EPB41L5	1	EPB41L5 [cytosol] (R-HSA-6797564)	0.527	3
UniProt:Q9NX58 LYAR			0.527	3
UniProt:Q8NI36 WDR36	1	WDR36 [nucleoplasm] (R-HSA-6790623)	0.527	3
UniProt:O00165 HAX1			0.527	2
IntAct:EBI-1265559 MYC			0.527	3
UniProt:Q13823 NOG2			0.527	3
UniProt:P08865 RPSA	3	RPSA [cytosol] (R-HSA-72389) RPSA [plasma membrane] (R-HSA-9922472) RPSA [nucleoplasm] (R-HSA-6798722)	0.527	3
UniProt:P62244 RPS15A	2	RPS15A [cytosol] (R-HSA-72345) RPS15A [nucleoplasm] (R-HSA-6791191)	0.527	3
UniProt:Q9NSY1 BMP2K			0.527	3
UniProt:Q9UPN3 MACF1			0.527	3
UniProt:Q14684 RRP1B			0.527	3
UniProt:P60866 RPS20	3	RPS20 [cytosol] (R-HSA-72349) K63polyUb-K8-RPS20 [cytosol] (R-HSA-9948312) RPS20 [nucleoplasm] (R-HSA-6798727)	0.527	2
UniProt:Q9NPD3 EXOSC4	3	EXOSC4 [nucleolus] (R-HSA-9935803) EXOSC4 [nucleoplasm] (R-HSA-6791503) EXOSC4 [cytosol] (R-HSA-430013)	0.527	3
UniProt:Q92754 TFAP2C	3	monoSUMO1-K10-TFAP2C [nucleoplasm] (R-HSA-3234071) TFAP2C [cytosol] (R-HSA-8864579) TFAP2C [nucleoplasm] (R-HSA-3234058)	0.527	3
UniProt:Q7Z406 MYH14	1	MYH14 [cytosol] (R-HSA-419176)	0.527	2
UniProt:O95793 STAU1			0.527	2
UniProt:Q9BY89 K1671			0.527	3
UniProt:Q5M775 CYTSB			0.527	3
UniProt:P27708 CAD	1	CAD [cytosol] (R-HSA-73452)	0.527	3
UniProt:Q9Y399 MRPS2	2	MRPS2 [mitochondrial inner membrane] (R-HSA-8866677) MRPS2 [mitochondrial matrix] (R-HSA-9839682)	0.527	3
UniProt:Q15084 PDIA6	3	PDIA6 [endoplasmic reticulum lumen] (R-HSA-3009049) p-PDIA6 [endoplasmic reticulum lumen] (R-HSA-8957031) PDIA6 [endoplasmic reticulum membrane] (R-HSA-535530)	0.527	3
UniProt:P07205 PGK2	1	PGK2 [cytosol] (R-HSA-6807622)	0.527	2
UniProt:Q9BUF5 TUBB6	6	TUBB6 [cytosol] (R-HSA-191698) TUBB6 [axonemal microtubule] (R-HSA-5610438) Polyglutamyl-TUBB6 [cytosol] (R-HSA-8867399) Polyglycyl-TUBB6 [cytosol] (R-HSA-8867396) TUBB6 unfolded [cytosol] (R-HSA-392780) TUBB6 folding intermediate [cytosol] (R-HSA-392787)	0.527	3
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.527	3
UniProt:P56192 MARS1	1	MARS [cytosol] (R-HSA-379657)	0.527	3
UniProt:Q04637 EIF4G1	2	EIF4G1 [cytosol] (R-HSA-72584) p-S1108,S1148,S1192-EIF4G1 [cytosol] (R-HSA-165762)	0.527	3
UniProt:P42224 STAT1	8	STAT1 [cytosol] (R-HSA-629622) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-Y701-STAT1 [cytosol] (R-HSA-8951202) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-STAT1 [cytosol] (R-HSA-8950418) p-STAT1 [nucleoplasm] (R-HSA-8987140) p-Y701-STAT1 [cytosol] (R-HSA-3132766) p-Y701,S727-STAT1 [cytosol] (R-HSA-9850842)	0.527	3
UniProt:O75146 HIP1R	3	HIP1R [Golgi membrane] (R-HSA-434348) HIP1R [cytoplasmic vesicle membrane] (R-HSA-434201) HIP1R [cytosol] (R-HSA-8868155)	0.527	3
UniProt:Q96L91 EP400	1	EP400 [nucleoplasm] (R-HSA-3321987)	0.527	3
UniProt:O60784 TOM1	3	TOM1 [azurophil granule membrane] (R-HSA-6799348) TOM1 [plasma membrane] (R-HSA-6806274) TOM1 [specific granule membrane] (R-HSA-6800923)	0.527	3
UniProt:O75110 ATP9A	1	ATP9A [plasma membrane] (R-HSA-939754)	0.527	3
UniProt:P28290 ITPI2			0.527	3
UniProt:P82650 MRPS22	1	MRPS22 [mitochondrial inner membrane] (R-HSA-5368259)	0.527	3
UniProt:P12268 IMPDH2	4	IMPDH2 [cytosol] (R-HSA-57350) IMPDH2 [secretory granule lumen] (R-HSA-6803323) IMPDH2 [extracellular region] (R-HSA-6806455) IMPDH2 [ficolin-1-rich granule lumen] (R-HSA-6803330)	0.527	3
UniProt:Q92665 MRPS31	1	MRPS31 [mitochondrial inner membrane] (R-HSA-5368198)	0.527	3
UniProt:O43432 EIF4G3	1	EIF4G3 [cytosol] (R-HSA-1678827)	0.527	3
UniProt:Q96EY7 PTCD3	1	PTCD3 [mitochondrial inner membrane] (R-HSA-5368165)	0.527	3
UniProt:Q8IYT4 KATL2			0.527	2
UniProt:P53680 AP2S1	4	AP2S1 [cytosol] (R-HSA-182197) AP2S1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130707) AP2S1 [plasma membrane] (R-HSA-389382) AP2S1 [endolysosome membrane] (R-HSA-6784821)	0.527	3
UniProt:Q9UBF2 COPG2	4	COPG2 [endoplasmic reticulum membrane] (R-HSA-6810962) COPG2 [Golgi membrane] (R-HSA-6808751) COPG2 [transport vesicle] (R-HSA-6808753) COPG2 [cytosol] (R-HSA-6807747)	0.527	3
UniProt:P62158 CALM			0.527	3
UniProt:Q92552 MRPS27	1	MRPS27 [mitochondrial inner membrane] (R-HSA-5368214)	0.527	3
UniProt:P62952 BLCAP			0.527	2
UniProt:O60568 PLOD3	1	PLOD3 [endoplasmic reticulum membrane] (R-HSA-1981135)	0.527	2
UniProt:P12814 ACTN1	3	ACTN1 [platelet alpha granule lumen] (R-HSA-349724) ACTN1 [extracellular region] (R-HSA-349722) ACTN1 [cytosol] (R-HSA-354096)	0.527	3
UniProt:Q9Y4P3 TBL2			0.527	3
UniProt:Q9NQZ2 UTP3	1	UTP3 [nucleoplasm] (R-HSA-6790637)	0.527	3
UniProt:Q9BRD0 BUD13	1	BUD13 [nucleoplasm] (R-HSA-9769522)	0.527	3
UniProt:Q9UN36 NDRG2			0.527	2
UniProt:Q7Z2W4 ZC3HAV1	2	ZC3HAV1(2-624)-BRAF(439-766) fusion [cytosol] (R-HSA-6802506) ZC3HAV1(2-624)-p-BRAF(439-766) fusion [cytosol] (R-HSA-6802557)	0.527	3
UniProt:O43175 PHGDH	1	PHGDH [cytosol] (R-HSA-977340)	0.527	3
UniProt:Q15291 RBBP5	1	RBBP5 [nucleoplasm] (R-HSA-1629836)	0.527	4
UniProt:P05089 ARG1	17	ARG1 [cytosol] (R-HSA-70561) ARG1 [azurophil granule lumen] (R-HSA-6798764) ARG1 [extracellular region] (R-HSA-6806221) ARG1 [specific granule lumen] (R-HSA-6801011) ARG1 G235R [cytosol] (R-HSA-9959604) ARG1 W122* [cytosol] (R-HSA-9959633) ARG1 T134I [cytosol] (R-HSA-9959627) ARG1 R291* [cytosol] (R-HSA-9959621) ARG1 R21* [cytosol] (R-HSA-9959618) ARG1 R180T [cytosol] (R-HSA-9959616) ARG1 T290S [cytosol] (R-HSA-9959631) ARG1 A125V [cytosol] (R-HSA-9959598) ARG1 G27D [cytosol] (R-HSA-9959606) ARG1 G138V [cytosol] (R-HSA-9959601) ARG1 I11T [cytosol] (R-HSA-9959613) ARG1 G74V [cytosol] (R-HSA-9959609) ARG1 R308Q [cytosol] (R-HSA-9959625)	0.527	2
UniProt:Q8WUY1 THEM6			0.527	3
UniProt:Q9Y2R5 MRPS17	1	MRPS17 [mitochondrial inner membrane] (R-HSA-5368241)	0.527	2
UniProt:Q6NYC8 PPR18			0.527	3
UniProt:Q8NHW5 RLA0L			0.527	2
UniProt:Q9BVJ6 UTP14A	1	UTP14A [nucleoplasm] (R-HSA-6790695)	0.527	3
UniProt:Q9H3U1 UN45A			0.527	3
UniProt:P62191 PSMC1	2	PSMC1 [cytosol] (R-HSA-68768) PSMC1 [nucleoplasm] (R-HSA-174338)	0.527	3
UniProt:O00429 DNM1L	2	DNM1L [cytosol] (R-HSA-351943) DNM1L [mitochondrial outer membrane] (R-HSA-351942)	0.527	2
UniProt:P60842 EIF4A1	1	EIF4A1 [cytosol] (R-HSA-72573)	0.527	3
UniProt:Q96KN2 CNDP1			0.527	2
UniProt:Q9Y4I1 MYO5A	2	p-S1652-MYO5A [cytosol] (R-HSA-1449606) MYO5A [cytosol] (R-HSA-1428499)	0.527	3
UniProt:P25398 RPS12	2	RPS12 [cytosol] (R-HSA-72329) RPS12 [nucleoplasm] (R-HSA-6798715)	0.527	2
UniProt:Q9UM54 MYO6	3	MYO6 [plasma membrane] (R-HSA-3006691) MYO6 [lysosomal membrane] (R-HSA-3006694) MYO6 [cytosol] (R-HSA-3006692)	0.527	2
UniProt:Q15233 NONO			0.527	3
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.527	3
UniProt:Q96HI0 SENP5	1	SENP5 [nucleoplasm] (R-HSA-2984297)	0.527	2
UniProt:Q9BUP0 EFHD1			0.527	2
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.527	3
UniProt:Q7L2E3 DHX30			0.527	3
UniProt:Q99575 POP1	1	POP1 [nucleoplasm] (R-HSA-5696802)	0.527	3
UniProt:Q9BQ39 DDX50			0.527	3
UniProt:Q9Y3U8 RPL36	1	RPL36 [cytosol] (R-HSA-72464)	0.527	3
UniProt:P50454 SERPINH1	1	SERPINH1 [endoplasmic reticulum lumen] (R-HSA-2127480)	0.527	3
UniProt:Q8N201 INTS1	1	INTS1 [nucleoplasm] (R-HSA-6807446)	0.527	3
UniProt:Q8IXJ9 ASXL1	1	ASXL1 [nucleoplasm] (R-HSA-5689645)	0.527	2
UniProt:Q9Y230 RUVBL2	1	RUVBL2 [nucleoplasm] (R-HSA-418321)	0.527	2
UniProt:Q9UBL3 ASH2L	1	ASH2L [nucleoplasm] (R-HSA-1629834)	0.527	4
UniProt:P46940 IQGAP1	3	IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [plasma membrane] (R-HSA-381681)	0.527	3
UniProt:P32455 GBP1	6	GBP1 [cytosol] (R-HSA-1031698) S-farn-C589-GBP1 [cytosol] (R-HSA-9947912) S-farn-C589, p-S156, T590-GBP1 [cytosol] (R-HSA-9954274) GBP1(1-192) [cytosol] (R-HSA-9956711) GBP1(193-592) [cytosol] (R-HSA-9956716) K48polyUb-GBP1 [cytosol] (R-HSA-9955186)	0.527	2
UniProt:O14686 KMT2D	20	KMT2D R5471M [nucleoplasm] (R-HSA-9946506) KMT2D W5217R [nucleoplasm] (R-HSA-9946443) KMT2D H5059P [nucleoplasm] (R-HSA-9945069) KMT2D R5340Q [nucleoplasm] (R-HSA-9946447) KMT2D R3321* [nucleoplasm] (R-HSA-9949952) KMT2D E5425K [nucleoplasm] (R-HSA-9946502) KMT2D Y5510D [nucleoplasm] (R-HSA-9946521) KMT2D M999Yfs69 [nucleoplasm] (R-HSA-9949980) KMT2D K1885Qfs18 [nucleoplasm] (R-HSA-9949981) KMT2D G5189R [nucleoplasm] (R-HSA-9946430) KMT2D T5098P [nucleoplasm] (R-HSA-9946431) KMT2D R2635* [nucleoplasm] (R-HSA-9949939) KMT2D R3707* [nucleoplasm] (R-HSA-9949940) KMT2D R5027* [nucleoplasm] (R-HSA-9949941) KMT2D E5008* [nucleoplasm] (R-HSA-9949943) KMT2D L449Vfs5 [nucleoplasm] (R-HSA-9952106) KMT2D Q2004 [nucleoplasm] (R-HSA-9951082) KMT2D I1509Vfs6 [nucleoplasm] (R-HSA-9952107) KMT2D R1687Tfs4 [nucleoplasm] (R-HSA-9952109) KMT2D Q4230* [nucleoplasm] (R-HSA-9951085)	0.525	3
UniProt:Q99966 CITED1	1	CITED1 [nucleoplasm] (R-HSA-8864301)	0.524	3
UniProt:P42229 STAT5A	4	p-Y694-STAT5A [cytosol] (R-HSA-507936) STAT5A [cytosol] (R-HSA-380747) p-Y694-STAT5A [nucleoplasm] (R-HSA-507995) STAT5A [nucleoplasm] (R-HSA-9701901)	0.524	2
UniProt:Q9H467 CUED2			0.524	2
UniProt:Q9BTK6 PAGR1	1	PAGR1 [nucleoplasm] (R-HSA-5619374)	0.524	5
UniProt:Q00987 MDM2	11	p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) MDM2 [cytosol] (R-HSA-198644) MDM2 [nucleoplasm] (R-HSA-69486) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) MDM2 [endocytic vesicle membrane] (R-HSA-416849) MDM2 [plasma membrane] (R-HSA-416843) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472)	0.508	2
UniProt:Q9JLI4 NCOA6			0.508	2
UniProt:Q60974 Ncor1	3	Ncor1 [cytosol] (R-MMU-1253324) Ncor1 [nucleoplasm] (R-MMU-442459) Ncor1 [nucleoplasm] (R-MMU-442501)	0.508	2
UniProt:Q99623 PHB2	1	PHB2 [mitochondrial inner membrane] (R-HSA-8953721)	0.508	4
UniProt:P59598	1	Asxl1 [nucleoplasm] (R-MMU-5689645)	0.508	2
UniProt:Q12778 FOXO1	5	FOXO1 [nucleoplasm] (R-HSA-199300) p-T24,S256,S319-FOXO1 [nucleoplasm] (R-HSA-199306) p-T24,S256,S319-FOXO1 [cytosol] (R-HSA-211158) Ac-K245,K248,K265-FOXO1 [nucleoplasm] (R-HSA-9626942) p-S218-FOXO1 [nucleoplasm] (R-HSA-5692651)	0.508	2
UniProt:P20290-2 BTF3			0.508	5
UniProt:Q9NV06 DCAF13	1	DCAF13 [nucleoplasm] (R-HSA-6790673)	0.499	2
UniProt:O95835 LATS1	2	LATS1 [cytosol] (R-HSA-2028562) p-S909,T1079-LATS1 [cytosol] (R-HSA-2028551)	0.499	2
UniProt:PGR ENSG00000082175			0.499	3
UniProt:Q9NPJ4 PNRC2	1	PNRC2 [cytosol] (R-HSA-8879146)	0.488	2
UniProt:P27986 PIK3R1	16	PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) p-Y-PIK3R1 [cytosol] (R-HSA-9680647)	0.483	7
UniProt:Q925T6	2	Grip1 [plasma membrane] (R-MMU-416638) Grip1 [cytosol] (R-MMU-416633)	0.482	2
UniProt:O43791 SPOP	3	SPOP [cytosol] (R-HSA-9929375) p-S6-SPOP [cytosol] (R-HSA-9929374) SPOP [nucleoplasm] (R-HSA-5635035)	0.471	5
UniProt:P83881 RPL36A	1	RPL36A [cytosol] (R-HSA-72480)	0.462	2
UniProt:O76021 RL1D1			0.462	2
UniProt:P62266 RPS23	3	RPS23 [cytosol] (R-HSA-72353) RPS23 [nucleoplasm] (R-HSA-6791209) 3OHP62-RPS23 [nucleoplasm] (R-HSA-9630773)	0.462	2
UniProt:hCG_2020860 A0A024RC46			0.462	2
UniProt:P38159 RBMX	2	RBMX [cytosol] (R-HSA-9715135) RBMX [nucleoplasm] (R-HSA-71939)	0.462	2
UniProt:Q9NYF8 BCLF1			0.462	2
UniProt:Q07020 RPL18	1	RPL18 [cytosol] (R-HSA-72420)	0.462	2
UniProt:P61978 HNRNPK	2	HNRNPK [nucleoplasm] (R-HSA-71945) polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532)	0.462	2
UniProt:Q01844 EWS			0.462	2
UniProt:Q8IYB3 SRRM1	2	SRRM1 [nucleoplasm] (R-HSA-156781) SRRM1 [cytosol] (R-HSA-159255)	0.462	2
UniProt:P39023 RPL3	1	RPL3 [cytosol] (R-HSA-72448)	0.462	2
UniProt:P62249 RPS16	2	RPS16 [cytosol] (R-HSA-72337) RPS16 [nucleoplasm] (R-HSA-6791196)	0.462	2
UniProt:O00159 MYO1C	1	MYO1C [cytosol] (R-HSA-1449619)	0.462	2
UniProt:P62241 RPS8	2	RPS8 [cytosol] (R-HSA-72385) RPS8 [nucleoplasm] (R-HSA-6791203)	0.462	2
UniProt:Q08211 DHX9	3	DHX9 [cytosol] (R-HSA-847700) p-DHX9 [cytosol] (R-HSA-9836168) DHX9 [nucleoplasm] (R-HSA-53517)	0.462	2
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070) Ub-105-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783103) Ub-27-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783038) Ub-179-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783114)	0.462	2
UniProt:Q16629 SRSF7	1	SRSF7 [nucleoplasm] (R-HSA-72029)	0.462	2
UniProt:Q14444 CAPR1			0.462	2
UniProt:P17480 UBTF	2	UBTF [nucleoplasm] (R-HSA-73683) p-UBTF [nucleoplasm] (R-HSA-76039)	0.462	2
UniProt:Q6PJG2 MDEAS			0.462	2
UniProt:P05141 SLC25A5	1	SLC25A5 [mitochondrial inner membrane] (R-HSA-49743)	0.462	2
UniProt:Q9NVP1 DDX18			0.462	2
UniProt:P02787 TF	6	apoTF [extracellular region] (R-HSA-350754) apoTF [endosome membrane] (R-HSA-917974) TF [endoplasmic reticulum lumen] (R-HSA-8956763) p-TF [endoplasmic reticulum lumen] (R-HSA-8957001) apoTF [clathrin-coated endocytic vesicle membrane] (R-HSA-8869140) TF [secretory granule lumen] (R-HSA-350704)	0.462	2
UniProt:P02786 TFRC	5	TFRC(1-760) [plasma membrane] (R-HSA-917983) TFRC(1-760) [endosome membrane] (R-HSA-8961829) TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (R-HSA-8869124) TFRC(1-760) [cytoplasmic vesicle membrane] (R-HSA-434196) TFRC(1-760) [Golgi membrane] (R-HSA-434330)	0.462	2
UniProt:P62917 RPL8	3	RPL8 [cytosol] (R-HSA-72490) RPL8 [nucleoplasm] (R-HSA-9630985) 3OHH216-RPL8 [nucleoplasm] (R-HSA-9630976)	0.462	2
UniProt:Q96PK6 RBM14	1	RBM14 [nucleoplasm] (R-HSA-8938345)	0.462	2
UniProt:P04843 RPN1	1	RPN1 [endoplasmic reticulum membrane] (R-HSA-264994)	0.462	2
UniProt:P04844 RPN2	1	RPN2 [endoplasmic reticulum membrane] (R-HSA-264937)	0.462	2
UniProt:P36578 RPL4	1	RPL4 [cytosol] (R-HSA-72474)	0.462	2
UniProt:P09874 PARP1	4	PARP1 [nucleoplasm] (R-HSA-201568) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617)	0.462	2
UniProt:P46013 KI67			0.462	2
UniProt:Q14669 TRIP12	1	TRIP12 [cytosol] (R-HSA-976046)	0.462	2
UniProt:Q9P035 HACD3	1	PTPLAD1 [endoplasmic reticulum membrane] (R-HSA-5676074)	0.462	2
UniProt:P15880 RPS2	3	RPS2 [cytosol] (R-HSA-72347) Me2aR-RPS2 [cytosol] (R-HSA-8879138) RPS2 [nucleoplasm] (R-HSA-6790655)	0.462	2
UniProt:P11387 TOP1	2	TOP1 [nucleoplasm] (R-HSA-4641363) monoSUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364)	0.462	2
UniProt:P11388 TOP2A	3	TOP2A [nucleoplasm] (R-HSA-1362276) polySUMO2,3-TOP2A [nucleoplasm] (R-HSA-4641298) monoSUMO1-K-TOP2A [nucleoplasm] (R-HSA-4641367)	0.462	2
UniProt:P83731 RPL24	1	RPL24 [cytosol] (R-HSA-72434)	0.462	2
UniProt:P11940 PABPC1	1	PABPC1 [cytosol] (R-HSA-156803)	0.462	2
UniProt:P68032 ACTC1	1	ACTC1 [cytosol] (R-HSA-390536)	0.462	2
UniProt:P09651 HNRNPA1	2	HNRNPA1 [nucleoplasm] (R-HSA-71927) HNRNPA1 [cytosol] (R-HSA-9727902)	0.462	2
UniProt:Q02543 RPL18A	1	RPL18A [cytosol] (R-HSA-72422)	0.462	2
UniProt:P19338 NCL	4	NCL [cytosol] (R-HSA-450514) NCL [plasma membrane] (R-HSA-9836466) NCL [macropinosome membrane] (R-HSA-9837666) NCL [nucleoplasm] (R-HSA-6791213)	0.462	2
UniProt:O43795 MYO1B			0.462	2
UniProt:P18124 RPL7	1	RPL7 [cytosol] (R-HSA-72486)	0.462	2
UniProt:O00571 DDX3X	4	DDX3X [secretory granule lumen] (R-HSA-6801275) DDX3X [extracellular region] (R-HSA-6806507) DDX3X [ficolin-1-rich granule lumen] (R-HSA-6801273) DDX3X [nucleoplasm] (R-HSA-9921623)	0.462	2
UniProt:P62424 RPL7A	1	RPL7A [cytosol] (R-HSA-72488)	0.462	2
UniProt:Q32P51 RA1L2			0.462	2
UniProt:Q02880 TOP2B	2	TOP2B [nucleoplasm] (R-HSA-4641359) monoSUMO1-K-TOP2B [nucleoplasm] (R-HSA-4641297)	0.462	2
UniProt:Q14980 NUMA1	3	NUMA1 [nucleoplasm] (R-HSA-380443) p-T2055-NUMA1 [nucleoplasm] (R-HSA-380473) p-NUMA1 [cytosol] (R-HSA-380484)	0.462	2
UniProt:Q9BZE4 GTPB4			0.462	2
UniProt:O00567 NOP56	2	NOP56 [nucleoplasm] (R-HSA-6790696) NOP56 [cytosol] (R-HSA-391293)	0.462	2
UniProt:Q9NVI7 ATD3A			0.462	2
UniProt:P61313 RPL15	1	RPL15 [cytosol] (R-HSA-72416)	0.462	2
UniProt:P35268 RPL22	1	RPL22 [cytosol] (R-HSA-72428)	0.462	2
UniProt:P14923 JUP	7	JUP [plasma membrane] (R-HSA-437260) JUP [cytosol] (R-HSA-201598) p-Y-JUP [cytosol] (R-HSA-9934829) JUP [specific granule lumen] (R-HSA-6799534) JUP [extracellular region] (R-HSA-6806309) JUP [ficolin-1-rich granule lumen] (R-HSA-6801028) JUP [cornified envelope] (R-HSA-8847739)	0.462	2
UniProt:Q96HS1 PGAM5			0.462	2
UniProt:P52272 HNRNPM	1	HNRNPM [nucleoplasm] (R-HSA-71949)	0.462	2
UniProt:Q02878 RPL6	1	RPL6 [cytosol] (R-HSA-72484)	0.462	2
UniProt:P62753 RPS6	4	RPS6 [cytosol] (R-HSA-72381) p-5S-RPS6 [cytosol] (R-HSA-165727) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) RPS6 [nucleoplasm] (R-HSA-6790606)	0.462	2
UniProt:P51991 HNRNPA3	1	HNRNPA3 [nucleoplasm] (R-HSA-71931)	0.462	2
UniProt:P50914 RPL14	1	RPL14 [cytosol] (R-HSA-72414)	0.462	2
UniProt:P18621 RPL17	1	RPL17 [cytosol] (R-HSA-72418)	0.462	2
UniProt:P26373 RPL13	1	RPL13 [cytosol] (R-HSA-72410)	0.462	2
UniProt:P84098 RPL19	1	RPL19 [cytosol] (R-HSA-72424)	0.462	2
UniProt:P26368 U2AF2	2	U2AF2 [nucleoplasm] (R-HSA-71987) 5OHK15,276-U2AF2 [nucleoplasm] (R-HSA-9630011)	0.462	2
UniProt:P46776 RPL27A	3	RPL27A [cytosol] (R-HSA-72442) RPL27A [nucleoplasm] (R-HSA-9630984) 3OHH39-RPL27A [nucleoplasm] (R-HSA-9630970)	0.462	2
UniProt:Q9Y2W1 THRAP3	1	THRAP3 [nucleoplasm] (R-HSA-8932115)	0.462	2
UniProt:O43390 HNRNPR	1	HNRNPR [nucleoplasm] (R-HSA-71951)	0.462	2
UniProt:Q8TDD1 DDX54			0.462	2
UniProt:Q9BQG0 MYBBP1A	1	MYBBP1A [nucleoplasm] (R-HSA-5250650)	0.462	2
UniProt:Q07955 SRSF1	1	SRSF1 [nucleoplasm] (R-HSA-72031)	0.462	2
UniProt:Q9H0A0 NAT10	1	NAT10 [nucleoplasm] (R-HSA-6791008)	0.462	2
UniProt:P35637 FUS	1	FUS [nucleoplasm] (R-HSA-72040)	0.462	2
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.462	2
UniProt:Q14498 RBM39	1	RBM39 [nucleoplasm] (R-HSA-9770254)	0.462	2
UniProt:P40429 RPL13A	2	RPL13A [cytosol] (R-HSA-72412) p-RPL13A [cytosol] (R-HSA-156829)	0.462	2
UniProt:Q12905 ILF2	5	ILF2 [cytosol] (R-HSA-9836392) ILF2 [tertiary granule lumen] (R-HSA-6800995) ILF2 [extracellular region] (R-HSA-6799684) ILF2 [specific granule lumen] (R-HSA-6799611) ILF2 [ficolin-1-rich granule lumen] (R-HSA-6801001)	0.462	2
UniProt:P52597 HNRNPF	2	HNRNPF [nucleoplasm] (R-HSA-71937) HNRNPF [plasma membrane] (R-HSA-8950714)	0.462	2
UniProt:O43143 DHX15	1	DHX15 [nucleoplasm] (R-HSA-5688097)	0.462	2
UniProt:Q8IY81 FTSJ3	1	FTSJ3 [nucleoplasm] (R-HSA-6791507)	0.462	2
UniProt:P46781 RPS9	2	RPS9 [cytosol] (R-HSA-72387) RPS9 [nucleoplasm] (R-HSA-6790663)	0.462	2
UniProt:Q92769 HDAC2	2	HDAC2 [nucleoplasm] (R-HSA-205135) monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958)	0.462	2
UniProt:O60832 DKC1	1	DKC1 [nucleoplasm] (R-HSA-163102)	0.462	2
UniProt:P61247 RPS3A	2	RPS3A [cytosol] (R-HSA-72373) RPS3A [nucleoplasm] (R-HSA-6791182)	0.462	2

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