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About
What is Reactome ?
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Team
Scientific Advisory Board
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Release Calendar
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Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
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Table of Contents
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Docs
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p-T180,Y182-MAPK14 [nucleoplasm]
Stable Identifier
R-HSA-446227
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p-T180,Y182-MAP kinase p38 alpha, Mitogen-activated protein kinase 14(phosphorylated), MK14_HUMAN, pp38 alpha
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p-p38 MAPK: MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Homo sapiens)
phospho-p38 MAPK: MAPKAPK5 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
p-p38 MAPK: MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Active p38 MAPK phosphorylates MAPKAPK5 (Homo sapiens)
phospho-p38 MAPK: MAPKAPK5 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
phospho-p38 MAPK:p-T-182-MAPKAPK5 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
MAPKAPK2/3-mediated removal of PRC1.4 complex stimulates p14ARF transcription (Homo sapiens)
phospho-MAPK p38:p-MAPKAPK3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
MAPKAPK5 phosphorylates TP53 (Homo sapiens)
phospho-p38 MAPK:p-T-182-MAPKAPK5 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
p-MAPKAPK3 phosphorylates BMI1 (Homo sapiens)
phospho-MAPK p38:p-MAPKAPK3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
MITF-M-dependent gene expression (Homo sapiens)
Regulation of MITF-M-dependent genes involved in pigmentation (Homo sapiens)
USF1 is phosphorylated by p-MAPK14 (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Myogenesis (Homo sapiens)
Nuclear translocation of p38 MAPK (Homo sapiens)
phospho-p38 alpha/beta/gamma MAPK [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Phosphorylation of E proteins by p38 MAPK (Homo sapiens)
phospho-p38 alpha/beta/gamma MAPK [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Phosphorylation of MEF2 proteins by p38 (Homo sapiens)
phospho p38:phospho MEF2 [nucleoplasm] (Homo sapiens)
phospho-p38 alpha/beta/gamma MAPK [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
phospho-p38 alpha/beta/gamma MAPK [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
MAPKAPK5 phosphorylates TP53 (Homo sapiens)
phospho-p38 MAPK:p-T-182-MAPKAPK5 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
Activation of the AP-1 family of transcription factors (Homo sapiens)
Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
p38MAPK phosphorylates MSK1 (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p-p38 MAPK: MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
p-p38 MAPK: MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Homo sapiens)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
Activation of the AP-1 family of transcription factors (Homo sapiens)
Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
p38MAPK phosphorylates MSK1 (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p-p38 MAPK: MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
p-p38 MAPK: MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Homo sapiens)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
Activation of the AP-1 family of transcription factors (Homo sapiens)
Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
p38MAPK phosphorylates MSK1 (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p-p38 MAPK: MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
p-p38 MAPK: MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Homo sapiens)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
Activation of the AP-1 family of transcription factors (Homo sapiens)
Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
p38MAPK phosphorylates MSK1 (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p-p38 MAPK: MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
p-p38 MAPK: MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Homo sapiens)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
Activation of the AP-1 family of transcription factors (Homo sapiens)
Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
p38MAPK phosphorylates MSK1 (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p-p38 MAPK: MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
p-p38 MAPK: MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Homo sapiens)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
Activation of the AP-1 family of transcription factors (Homo sapiens)
Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
p38MAPK phosphorylates MSK1 (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p-p38 MAPK: MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
p-p38 MAPK: MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Homo sapiens)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
Activation of the AP-1 family of transcription factors (Homo sapiens)
Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
p38MAPK phosphorylates MSK1 (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p-p38 MAPK: MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
p-p38 MAPK: MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Homo sapiens)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
Activation of the AP-1 family of transcription factors (Homo sapiens)
Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
p38MAPK phosphorylates MSK1 (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p-p38 MAPK: MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
p-p38 MAPK: MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Homo sapiens)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
Activation of the AP-1 family of transcription factors (Homo sapiens)
Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
p38MAPK phosphorylates MSK1 (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p-p38 MAPK: MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
p-p38 MAPK: MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Homo sapiens)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
Activation of the AP-1 family of transcription factors (Homo sapiens)
Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
p38MAPK phosphorylates MSK1 (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p-p38 MAPK: MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
p-p38 MAPK: MAPKAPK2,3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Homo sapiens)
p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Organelle biogenesis and maintenance (Homo sapiens)
Mitochondrial biogenesis (Homo sapiens)
Activation of PPARGC1A (PGC-1alpha) by phosphorylation (Homo sapiens)
p38 MAPK phosphorylates PPARGC1A (Homo sapiens)
phospho-p38 alpha/beta/gamma MAPK [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
p38MAPK phosphorylates MSK1 (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16539 MAPK14
Gene Names
MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2, SAPK2A
Chain
initiator methionine:, chain:2-360
Reference Genes
COSMIC (genes):MAPK14 MAPK14
dbSNP Gene:1432 MAPK14
ENSEMBL:ENSG00000112062 MAPK14
Participates
as a member of
phospho-p38 alpha/beta/gamma MAPK [nucleoplasm] (Homo sapiens)
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
Other forms of this molecule
MAPK14 [ficolin-1-rich granule lumen]
MAPK14 [extracellular region]
MAPK14 [secretory granule lumen]
MAPK14 [nucleoplasm]
MAPK14 [cytosol]
p-T180,Y182-MAPK14 [cytosol]
Inferred To
p-T180,Y182-Mapk14 [nucleoplasm]
(Mus musculus)
phospho-gskl-2 [nucleoplasm]
(Caenorhabditis elegans)
phospho-p-T180,Y182-MAPK14 [nucleoplasm]
(Bos taurus)
phospho-p-T180,Y182-MAPK14 [nucleoplasm]
(Caenorhabditis elegans)
phospho-p-T180,Y182-MAPK14 [nucleoplasm]
(Canis familiaris)
phospho-p-T180,Y182-MAPK14 [nucleoplasm]
(Danio rerio)
phospho-p-T180,Y182-MAPK14 [nucleoplasm]
(Dictyostelium discoideum)
phospho-p-T180,Y182-MAPK14 [nucleoplasm]
(Drosophila melanogaster)
phospho-p-T180,Y182-MAPK14 [nucleoplasm]
(Rattus norvegicus)
phospho-p-T180,Y182-MAPK14 [nucleoplasm]
(Saccharomyces cerevisiae)
phospho-p-T180,Y182-MAPK14 [nucleoplasm]
(Schizosaccharomyces pombe)
phospho-p-T180,Y182-MAPK14 [nucleoplasm]
(Sus scrofa)
phospho-p-T180,Y182-MAPK14 [nucleoplasm]
(Xenopus tropicalis)
phospho-MAPK14 [nucleoplasm]
(Gallus gallus)
Homologues of p-T180,Y182-MAPK14 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of p-T180,Y182-MAPK14 [nucleoplasm]
(Dictyostelium discoideum)
Homologues of p-T180,Y182-MAPK14 [nucleoplasm]
(Drosophila melanogaster)
Modified Residues
Name
O-phospho-L-threonine at 180
Coordinate
180
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O4'-phospho-L-tyrosine at 182
Coordinate
182
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Interactors (33)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49137 MAPKAPK2
5
MAPKAPK2 [cytosol]
(R-HSA-187743)
p-T222,S272-MAPKAPK2 [nucleoplasm]
(R-HSA-199936)
p-S272,T222,T334-MAPKAPK2 [cytosol]
(R-HSA-187760)
p-T222,S272,T334-MAPKAPK2 [nucleoplasm]
(R-HSA-450268)
MAPKAPK2 [nucleoplasm]
(R-HSA-450235)
0.93
15
UniProt:Q16644 MAPKAPK3
4
MAPKAPK3 [nucleoplasm]
(R-HSA-450218)
p-S,2T-MAPKAPK3 [nucleoplasm]
(R-HSA-450359)
p-S,2T-MAPKAPK3 [cytosol]
(R-HSA-187723)
MAPKAPK3 [cytosol]
(R-HSA-187764)
0.914
15
UniProt:O75676 RPS6KA4
1
RPS6KA4 [cytosol]
(R-HSA-772527)
0.829
9
UniProt:P46734 MAP2K3
3
MAP2K3 [cytosol]
(R-HSA-168051)
p-S218,T222-MAP2K3 [cytosol]
(R-HSA-167955)
p-S218,T222-MAP2K3 [nucleoplasm]
(R-HSA-450229)
0.802
7
UniProt:Q9BUB5 MKNK1
1
p-T250,T255,T385,S437-MKNK1 [cytosol]
(R-HSA-947860)
0.798
7
UniProt:Q9HBH9 MKNK2
0.788
5
UniProt:Q99956 DUSP9
1
DUSP9 [cytosol]
(R-HSA-5675351)
0.779
6
UniProt:P28562 DUSP1
1
DUSP1 [nucleoplasm]
(R-HSA-203796)
0.767
4
UniProt:Q8NEM7 SUPT20H
1
SUPT20H [nucleoplasm]
(R-HSA-3662286)
0.756
5
UniProt:O75147 OBSL1
1
OBSL1 [cytosol]
(R-HSA-8955929)
0.725
4
UniProt:O43257 ZNHI1
0.72
7
UniProt:Q15750 TAB1
6
TAB1 [cytosol]
(R-HSA-167923)
TAB1 [endosome membrane]
(R-HSA-450238)
TAB1(1-444) [cytosol]
(R-HSA-9729751)
TAB1(1-132) [cytosol]
(R-HSA-9729698)
TAB1(133-504) [cytosol]
(R-HSA-9729724)
TAB1(445-504) [cytosol]
(R-HSA-9729691)
0.713
4
UniProt:P27361 MAPK3
6
p-T202,Y204-MAPK3 [nucleoplasm]
(R-HSA-112359)
p-T202,Y204-MAPK3 [cytosol]
(R-HSA-109842)
MAPK3 [cytosol]
(R-HSA-59284)
MAPK3 [nucleoplasm]
(R-HSA-73724)
p-T202-MAPK3 [cytosol]
(R-HSA-9635775)
MAPK3 [endoplasmic reticulum lumen]
(R-HSA-9636295)
0.691
5
UniProt:Q15256 PTPRR
0.664
4
UniProt:Q9BY84 DUSP16
3
Ac-55-DUSP16 [cytosol]
(R-HSA-9636576)
DUSP16 [nucleoplasm]
(R-HSA-5675337)
DUSP16 [cytosol]
(R-HSA-5675336)
0.659
3
UniProt:Q9H0W5 CCDC8
1
CCDC8 [cytosol]
(R-HSA-8955915)
0.643
3
UniProt:P46940 IQGAP1
3
IQGAP1 [cytosol]
(R-HSA-5626371)
IQGAP1 [secretory granule membrane]
(R-HSA-6804803)
IQGAP1 [plasma membrane]
(R-HSA-381681)
0.643
4
UniProt:P06400 RB1
20
RB1 R661W [nucleoplasm]
(R-HSA-9659801)
RB1 C706F [nucleoplasm]
(R-HSA-9659812)
RB1 N480del [nucleoplasm]
(R-HSA-9659792)
RB1 C706Y [nucleoplasm]
(R-HSA-9659821)
RB1 R661Q [nucleoplasm]
(R-HSA-9659807)
RB1 I703_E737del [nucleoplasm]
(R-HSA-9661065)
RB1 R830_G887del [cytosol]
(R-HSA-9661059)
RB1 K791* [cytosol]
(R-HSA-9662284)
RB1 Q176* [cytosol]
(R-HSA-9661774)
RB1 S114* [cytosol]
(R-HSA-9661775)
RB1 K765* [cytosol]
(R-HSA-9662281)
RB1 W99* [cytosol]
(R-HSA-9661769)
RB1 S149* [cytosol]
(R-HSA-9661770)
RB1 E166* [cytosol]
(R-HSA-9661767)
RB1 G100* [cytosol]
(R-HSA-9661763)
RB1 E125* [cytosol]
(R-HSA-9661784)
RB1 Q121* [cytosol]
(R-HSA-9661780)
RB1 E184* [cytosol]
(R-HSA-9661781)
RB1 E137* [cytosol]
(R-HSA-9661782)
RB1 K745* [cytosol]
(R-HSA-9662288)
0.623
4
UniProt:Q16829 DUSP7
2
DUSP7 [cytosol]
(R-HSA-5675346)
DUSP7 [nucleoplasm]
(R-HSA-203791)
0.59
2
UniProt:P52564 MAP2K6
3
MAP2K6 [cytosol]
(R-HSA-167998)
p-S207,T211-MAP2K6 [cytosol]
(R-HSA-206255)
p-S207,T211-MAP2K6 [nucleoplasm]
(R-HSA-450258)
0.564
3
UniProt:P48730-2 CSNK1D
0.556
3
UniProt:Q9H869 YYAP1
0.553
2
UniProt:Q15759 MAPK11
4
p-T180,Y182-MAPK11 [cytosol]
(R-HSA-171009)
MAPK11 [cytosol]
(R-HSA-170989)
MAPK11 [nucleoplasm]
(R-HSA-203790)
p-T180,Y182-MAPK11 [nucleoplasm]
(R-HSA-198741)
0.547
2
UniProt:Q6PJG2 MDEAS
0.547
2
UniProt:O75582 RPS6KA5
3
p-S212,S360,S376,T581-RPS6KA5 [nucleoplasm]
(R-HSA-198683)
RPS6KA5 [nucleoplasm]
(R-HSA-198657)
RPS6KA5 [cytosol]
(R-HSA-772525)
0.547
3
UniProt:Q14814 MEF2D
1
MEF2D [nucleoplasm]
(R-HSA-445328)
0.547
2
UniProt:P68104 EEF1A1
7
EEF1A1 [lysosomal membrane]
(R-HSA-9626022)
EEF1A1 [cytosol]
(R-HSA-156905)
EEF1A1 [secretory granule lumen]
(R-HSA-6801479)
EEF1A1 [extracellular region]
(R-HSA-6806456)
EEF1A1 [ficolin-1-rich granule lumen]
(R-HSA-6801528)
Me3K318-EEF1A1 [cytosol]
(R-HSA-8932419)
Me3K79-EEF1A1 [cytosol]
(R-HSA-8932212)
0.547
3
UniProt:P51784 USP11
1
USP11 [cytosol]
(R-HSA-391303)
0.527
2
UniProt:P13639 EEF2
10
EEF2 [secretory granule lumen]
(R-HSA-6801504)
EEF2 [extracellular region]
(R-HSA-6806499)
EEF2 [ficolin-1-rich granule lumen]
(R-HSA-6801513)
EEF2 [cytosol]
(R-HSA-156901)
aminocarboxypropyl EEF2 [cytosol]
(R-HSA-5358478)
Me-diphthine EEF2 [cytosol]
(R-HSA-5367025)
nascent EEF2 [cytosol]
(R-HSA-5358472)
diphthine EEF2 [cytosol]
(R-HSA-5358501)
ADP-ribo-EEF2 [cytosol]
(R-HSA-5334764)
Me3K525-EEF2 [cytosol]
(R-HSA-8932237)
0.527
2
UniProt:Q96RR4 CAMKK2
4
p-CAMKK2 [nucleoplasm]
(R-HSA-9618968)
CAMKK2 [nucleoplasm]
(R-HSA-5336483)
p-CAMKK2 [cytosol]
(R-HSA-9619358)
CAMKK2 [cytosol]
(R-HSA-9619231)
0.527
2
UniProt:Q14999 CUL7
1
CUL7 [cytosol]
(R-HSA-535534)
0.527
2
UniProt:Q92574 TSC1
2
TSC1 [cytosol]
(R-HSA-5672338)
TSC1 [plasma membrane]
(R-HSA-165169)
0.508
2
UniProt:Q07352 ZFP36L1
3
p-S54,S92,S203-p-ZFP36L1 [cytosol]
(R-HSA-450384)
ZFP36L1 [cytosol]
(R-HSA-450547)
p-S92,S203-ZFP36L1 [cytosol]
(R-HSA-450618)
0.508
2
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