RhBG mediates ammonium influx into kidney collecting duct cells

Stable Identifier
R-HSA-446278
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The human gene RhBG encodes a Rhesus blood group family type B glycoprotein which is expressed mainly in the kidney but is also found in the liver. The liver and kidney are important tissues for ammonium metabolism and excretion. RhBG is located on the basolateral membrane and mediates the reversible transport of ammonium in and out of renal collecting duct cells in an electroneutral manner, with H+ transported the other way (Ludewig U, 2004; Liu Z et al, 2001).

Literature References
PubMed ID Title Journal Year
15284342 Electroneutral ammonium transport by basolateral rhesus B glycoprotein

Ludewig, U

J Physiol 2004
11024028 Rh type B glycoprotein is a new member of the Rh superfamily and a putative ammonia transporter in mammals

Liu, Z, Peng, J, Mo, R, Hui, C, Huang, CH

J Biol Chem 2001
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Event Information
Catalyst Activity
Catalyst Activity
Title
ammonium transmembrane transporter activity of RHBG [plasma membrane]
Physical Entity
Activity
Orthologous Events
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