Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
IRAK1 [cytosol]
Stable Identifier
R-HSA-446639
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Interleukin-1 receptor-associated kinase 1, IRAK1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by MECP2 (Homo sapiens)
IRAK1 gene expression is inhibited by MECP2 (Homo sapiens)
IRAK1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
IRAK1 binds to MYD88 within the IL1R complex (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Homo sapiens)
IRAK1 [cytosol] (Homo sapiens)
IRAK1 [cytosol] (Homo sapiens)
IRAK4 phosphorylates IRAK1 (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Homo sapiens)
IRAK1 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
IRAK1/or IRAK2 binds to the activated IRAK4 :oligo MyD88:activated TLR5 or 10 complex (Homo sapiens)
IRAK1, IRAK2 [cytosol] (Homo sapiens)
IRAK1 [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex (Homo sapiens)
IRAK1, IRAK2 [cytosol] (Homo sapiens)
IRAK1 [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex (Homo sapiens)
IRAK1, IRAK2 [cytosol] (Homo sapiens)
IRAK1 [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex (Homo sapiens)
IRAK1, IRAK2 [cytosol] (Homo sapiens)
IRAK1 [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
IRAK1/or IRAK2 binds to the activated IRAK4 :oligo MyD88:activated TLR5 or 10 complex (Homo sapiens)
IRAK1, IRAK2 [cytosol] (Homo sapiens)
IRAK1 [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK1, IRAK2 [cytosol] (Homo sapiens)
IRAK1 [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9 (Homo sapiens)
IRAK1, IRAK2 [cytosol] (Homo sapiens)
IRAK1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
p75NTR signals via NF-kB (Homo sapiens)
p75NTR recruits signalling complexes (Homo sapiens)
IRAK is activated (Homo sapiens)
NGF ligand:p75NTR:IRAK1:MYD88 [plasma membrane] (Homo sapiens)
IRAK1:MYD88 [cytosol] (Homo sapiens)
IRAK1 [cytosol] (Homo sapiens)
p75NTR interacts with IRAK:MYD88 (Homo sapiens)
IRAK1:MYD88 [cytosol] (Homo sapiens)
IRAK1 [cytosol] (Homo sapiens)
NGF ligand:p75NTR:IRAK1:MYD88 [plasma membrane] (Homo sapiens)
IRAK1:MYD88 [cytosol] (Homo sapiens)
IRAK1 [cytosol] (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Homo sapiens)
IRAK1 [cytosol] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Homo sapiens)
IRAK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P51617 IRAK1
Gene Names
IRAK1, IRAK
Chain
chain:1-712
Reference Genes
BioGPS Gene:3654 IRAK1
COSMIC (genes):IRAK1 IRAK1
CTD Gene:3654 IRAK1
dbSNP Gene:3654 IRAK1
ENSEMBL:ENSG00000184216 IRAK1
ENSEMBL_homo_sapiens_GENE:ENSG00000184216.15 IRAK1
HGNC:6112 IRAK1
KEGG Gene (Homo sapiens):3654 IRAK1
Monarch:3654 IRAK1
NCBI Gene:3654 IRAK1
OMIM:300283 IRAK1
UCSC:P51617 IRAK1
Reference Transcript
RefSeq:NM_001569.3 IRAK1
RefSeq:NM_001025243.1 IRAK1
RefSeq:NM_001025242.1 IRAK1
Other Identifiers
1100_at
11734006_a_at
1555784_PM_s_at
1555784_s_at
17115428
201587_PM_s_at
201587_s_at
3654
4027010
4027011
4027012
4027013
4027014
4027015
4027016
4027017
4027018
4027021
4027022
4027023
4027024
4027027
4027028
4027029
4027031
4027033
4027034
4027037
4027038
4027040
4027041
4027043
4027045
4027046
4027048
4027050
4027051
4027052
4027053
8175977
A_23_P73780
A_33_P3286616
GE62370
GO:0000166
GO:0001959
GO:0002224
GO:0002376
GO:0002755
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005811
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006468
GO:0007155
GO:0007165
GO:0007249
GO:0007254
GO:0008063
GO:0009986
GO:0010008
GO:0016301
GO:0016310
GO:0016740
GO:0019221
GO:0019901
GO:0023052
GO:0031072
GO:0031410
GO:0031663
GO:0032088
GO:0032481
GO:0032496
GO:0032991
GO:0034134
GO:0034142
GO:0034162
GO:0034605
GO:0035556
GO:0036211
GO:0038172
GO:0042802
GO:0042803
GO:0043123
GO:0043226
GO:0045087
GO:0046777
GO:0046982
GO:0048583
GO:0048661
GO:0051092
GO:0060337
GO:0070498
GO:0070555
GO:0071222
GO:0071345
GO:0071456
GO:0098542
GO:0106310
GO:0140096
GO:1904996
HMNXSV003048644
HMNXSV003053546
Hs2.182018.3.S1_3p_s_at
ILMN_2379130
L76191_at
PH_hs_0010754
TC0X001524.hg
g4755143_3p_s_at
Participates
as an output of
IRAK1 gene expression is inhibited by MECP2 (Homo sapiens)
as an input of
IRAK1 binds to MYD88 within the IL1R complex (Homo sapiens)
as a component of
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Homo sapiens)
IRAK1:MYD88 [cytosol] (Homo sapiens)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Homo sapiens)
as a member of
IRAK1, IRAK2 [cytosol] (Homo sapiens)
Other forms of this molecule
K63polyUb-hp-IRAK1 [endosome membrane]
p-S376,T387-IRAK1 [cytosol]
p-S,T-IRAK1 [cytosol]
K63polyUb-hp-IRAK1 [cytosol]
p-T209-IRAK1 [endosome membrane]
p-T209,T387-IRAK1 [endosome membrane]
IRAK1 [endosome membrane]
p-2S,S376,T,T209,T387-IRAK1 [endosome membrane]
IRAK1 [plasma membrane]
p-T209-IRAK1 [plasma membrane]
p-T209,T387-IRAK1 [plasma membrane]
p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]
p-2S,S376,T,T209,T387-IRAK1 [cytosol]
Inferred To
IRAK1 [cytosol]
(Bos taurus)
IRAK1 [cytosol]
(Canis familiaris)
IRAK1 [cytosol]
(Mus musculus)
IRAK1 [cytosol]
(Rattus norvegicus)
IRAK1 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_001020413.1
,
NP_001560.2
,
NP_001020414.1
ZINC - World Drugs
IRAK1_HUMAN
Guide to Pharmacology - Targets
2042
OpenTargets
ENSG00000184216
ZINC - FDA approved
IRAK1_HUMAN
ZINC - Substances
IRAK1_HUMAN
ZINC target
P51617
ZINC - Biogenic
IRAK1_HUMAN
PRO
P51617
PDB
6BFN
ZINC - Investigational
IRAK1_HUMAN
IntEnz
2.7.11.1
HPA
ENSG00000184216-IRAK1
GeneCards
P51617
Ensembl
ENST00000369980
,
ENSP00000377291
,
ENSP00000358991
,
ENSG00000184216
,
ENST00000369974
,
ENST00000393687
,
ENSP00000358997
Pharos - Targets
P51617
Orphanet
22427
ZINC - Predictions - Purchasable
IRAK1_HUMAN
HMDB Protein
HMDBP08733
Interactors (22)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y4K3 TRAF6
8
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
TRAF6 [endosome membrane]
(R-HSA-450272)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
0.77
4
UniProt:Q9HAT8 PELI2
2
PELI2 [cytosol]
(R-HSA-450694)
p-PELI2 [cytosol]
(R-HSA-450825)
0.743
4
UniProt:Q96FA3 PELI1
2
PELI1 [cytosol]
(R-HSA-450696)
p-PELI1 [cytosol]
(R-HSA-450815)
0.734
4
UniProt:Q99836 MYD88
8
MyD88 R196C [cytosol]
(R-HSA-5602329)
MyD88 E52del [cytosol]
(R-HSA-5602451)
MyD88 L93P [cytosol]
(R-HSA-5602612)
MyD88 S34Y [cytosol]
(R-HSA-5602521)
MyD88 E65del [cytosol]
(R-HSA-5602598)
MYD88 [endosome membrane]
(R-HSA-975123)
MYD88 [plasma membrane]
(R-HSA-937017)
MYD88 [cytosol]
(R-HSA-166059)
0.723
4
UniProt:Q13526 PIN1
2
PIN1 [cytosol]
(R-HSA-9626823)
PIN1 [nucleoplasm]
(R-HSA-936016)
0.645
10
UniProt:P58753 TIRAP
2
TIRAP [cytosol]
(R-HSA-166141)
p-4Y-TIRAP [plasma membrane]
(R-HSA-2201321)
0.623
3
UniProt:Q8N2H9-2 PELI3
0.589
2
UniProt:Q9Y616 IRAK3
1
IRAK3 [cytosol]
(R-HSA-166103)
0.564
3
UniProt:O43187 IRAK2
6
IRAK2 [endosome membrane]
(R-HSA-975116)
p-IRAK2 [endosome membrane]
(R-HSA-975187)
IRAK2 [plasma membrane]
(R-HSA-937014)
IRAK2 [cytosol]
(R-HSA-772534)
p-IRAK2 [plasma membrane]
(R-HSA-936949)
p-IRAK2 [cytosol]
(R-HSA-446636)
0.564
3
UniProt:Q9NWZ3 IRAK4
9
IRAK4 Q293* [cytosol]
(R-HSA-5602426)
IRAK4 R12C [cytosol]
(R-HSA-5602511)
IRAK4 E402* [cytosol]
(R-HSA-5602517)
p-T342,T345,S346-IRAK4 [cytosol]
(R-HSA-446649)
IRAK4 [endosome membrane]
(R-HSA-975167)
p-T342,T345,S346-IRAK4 [endosome membrane]
(R-HSA-975149)
IRAK4 [plasma membrane]
(R-HSA-937051)
p-T342,T345,S346-IRAK4 [plasma membrane]
(R-HSA-936957)
IRAK4 [cytosol]
(R-HSA-166081)
0.547
2
UniProt:Q5D1E7
1
ZC3H12A [nucleoplasm]
(R-MMU-9774235)
0.544
3
UniProt:P50402 EMD
4
EMD [nuclear envelope]
(R-HSA-201573)
EMD [cytosol]
(R-HSA-9613988)
EMD [endoplasmic reticulum membrane]
(R-HSA-9613998)
EMD [endosome membrane]
(R-HSA-9715092)
0.527
2
UniProt:O15027 SEC16A
1
SEC16A [cytosol]
(R-HSA-5685728)
0.527
2
UniProt:O60884 DNAJA2
1
DNAJA2 [cytosol]
(R-HSA-3371555)
0.527
2
UniProt:Q96EY1 DNJA3
0.527
2
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.527
2
UniProt:Q13451 FKBP5
2
FKBP5 [cytosol]
(R-HSA-5618096)
FKBP5 [nucleoplasm]
(R-HSA-8939165)
0.527
2
UniProt:P31689 DNAJA1
2
SOH-C149,C150-DNAJA1 [cytosol]
(R-HSA-9857072)
DNAJA1 [cytosol]
(R-HSA-3371544)
0.527
2
UniProt:Q8VCW4
2
Unc93b1 [endoplasmic reticulum membrane]
(R-MMU-1678930)
Unc93b1 [Golgi membrane]
(R-MMU-1679064)
0.499
2
UniProt:Q15306 IRF4
2
IRF4 [nucleoplasm]
(R-HSA-9907101)
IRF4 [cytosol]
(R-HSA-1015679)
0.499
2
UniProt:Q92985 IRF7
5
K63polyUb-IRF7 [endosome membrane]
(R-HSA-975154)
IRF7 [endosome membrane]
(R-HSA-450274)
p-S477,S479-IRF7 [nucleoplasm]
(R-HSA-450270)
p-S477,S479-IRF7 [cytosol]
(R-HSA-450318)
IRF7 [cytosol]
(R-HSA-450281)
0.499
2
UniProt:Q86WV6 STING1
5
TMEM173 [plasma membrane]
(R-HSA-6804815)
TMEM173 [secretory granule membrane]
(R-HSA-6804798)
K63polyUb-STING [endoplasmic reticulum membrane]
(R-HSA-3134805)
K63polyUb-STING [cytoplasmic vesicle membrane]
(R-HSA-3248021)
STING [endoplasmic reticulum membrane]
(R-HSA-1834940)
0.499
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text