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p-T342,T345,S346-IRAK4 [cytosol]
Stable Identifier
R-HSA-446649
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Activated IRAK4
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
Hyperphosphorylated IRAK1 associates with TRAF6 (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
p-T342,T345,S346-IRAK4 [cytosol] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
p-T342,T345,S346-IRAK4 [cytosol] (Homo sapiens)
IRAK1 binds to MYD88 within the IL1R complex (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
p-T342,T345,S346-IRAK4 [cytosol] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
p-T342,T345,S346-IRAK4 [cytosol] (Homo sapiens)
IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
p-T342,T345,S346-IRAK4 [cytosol] (Homo sapiens)
IRAK4 is activated by autophosphorylation (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
p-T342,T345,S346-IRAK4 [cytosol] (Homo sapiens)
IRAK4 phosphorylates IRAK1 (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
p-T342,T345,S346-IRAK4 [cytosol] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
p-T342,T345,S346-IRAK4 [cytosol] (Homo sapiens)
p-T342,T345,S346-IRAK4 [cytosol] (Homo sapiens)
IRAK4-activated IRAK1 autophosphorylates (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
p-T342,T345,S346-IRAK4 [cytosol] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
p-T342,T345,S346-IRAK4 [cytosol] (Homo sapiens)
TRAF6 binding leads to IRAK1:TRAF6 release (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Homo sapiens)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
p-T342,T345,S346-IRAK4 [cytosol] (Homo sapiens)
p-T342,T345,S346-IRAK4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NWZ3 IRAK4
Gene Names
IRAK4
Chain
chain:1-460
Reference Genes
BioGPS Gene:51135 IRAK4
COSMIC (genes):IRAK4 IRAK4
CTD Gene:51135 IRAK4
dbSNP Gene:51135 IRAK4
ENSEMBL:ENSG00000198001 IRAK4
ENSEMBL_homo_sapiens_GENE:ENSG00000198001.16 IRAK4
HGNC:17967 IRAK4
KEGG Gene (Homo sapiens):51135 IRAK4
Monarch:51135 IRAK4
NCBI Gene:51135 IRAK4
OMIM:606883 IRAK4
UCSC:Q9NWZ3 IRAK4
Reference Transcript
RefSeq:NM_001114182.2 IRAK4
RefSeq:XM_017019390.1 IRAK4
RefSeq:NM_001145256.1 IRAK4
RefSeq:XM_017019391.1 IRAK4
RefSeq:XM_005268947.4 IRAK4
RefSeq:NM_001145257.1 IRAK4
RefSeq:XM_005268948.2 IRAK4
RefSeq:NM_001145258.1 IRAK4
RefSeq:XM_005268949.2 IRAK4
RefSeq:XM_006719438.3 IRAK4
RefSeq:NM_016123.3 IRAK4
RefSeq:XM_005268943.3 IRAK4
RefSeq:XM_005268944.4 IRAK4
RefSeq:XM_006719439.2 IRAK4
RefSeq:XM_011538431.2 IRAK4
RefSeq:XM_011538432.1 IRAK4
RefSeq:XM_005268945.4 IRAK4
RefSeq:XM_011538433.2 IRAK4
Other Identifiers
11734066_x_at
11734067_a_at
11740649_a_at
11742042_a_at
16750277
219618_3p_at
219618_PM_at
219618_at
3412297
3412299
3412302
3412306
3412307
3412308
3412309
3412311
3412316
3412317
3412318
3412320
3412321
3412322
3412323
3412324
3412325
3412326
3412327
3412328
3412329
3412330
51135
7954969
81368_at
A_23_P13978
A_24_P158903
GE58687
GE595587
GO:0000166
GO:0000287
GO:0002224
GO:0002376
GO:0002446
GO:0002755
GO:0003824
GO:0004672
GO:0004674
GO:0005149
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005768
GO:0005829
GO:0005886
GO:0006468
GO:0006950
GO:0007165
GO:0007254
GO:0008063
GO:0009986
GO:0010008
GO:0016301
GO:0016310
GO:0016740
GO:0019221
GO:0019897
GO:0019901
GO:0023052
GO:0031349
GO:0031410
GO:0032103
GO:0034142
GO:0034162
GO:0035556
GO:0036211
GO:0038172
GO:0043123
GO:0043226
GO:0045087
GO:0048661
GO:0048870
GO:0070498
GO:0071222
GO:0071310
GO:0098542
GO:0106310
GO:0140096
GO:1990266
HMNXSV003043621
ILMN_1692352
TC12000325.hg
g7705840_3p_x_at
Participates
as an output of
TRAF6 binding leads to IRAK1:TRAF6 release (Homo sapiens)
as a component of
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)
Other forms of this molecule
IRAK4 Q293* [cytosol]
IRAK4 R12C [cytosol]
IRAK4 E402* [cytosol]
IRAK4 [endosome membrane]
p-T342,T345,S346-IRAK4 [endosome membrane]
IRAK4 [plasma membrane]
p-T342,T345,S346-IRAK4 [plasma membrane]
IRAK4 [cytosol]
Inferred To
Ghost homologue of p-T342,T345,S346-IRAK4 [cytosol]
(Gallus gallus)
Ghost homologue of p-T342,T345,S346-IRAK4 [cytosol]
(Xenopus tropicalis)
phospho-p-T342,T345,S346-IRAK4 [cytosol]
(Bos taurus)
phospho-p-T342,T345,S346-IRAK4 [cytosol]
(Mus musculus)
phospho-p-T342,T345,S346-IRAK4 [cytosol]
(Rattus norvegicus)
phospho-p-T342,T345,S346-IRAK4 [cytosol]
(Sus scrofa)
phospho-IRAK4 [cytosol]
(Canis familiaris)
Modified Residues
Name
O-phospho-L-threonine at 342
Coordinate
342
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at 345
Coordinate
345
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 346
Coordinate
346
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
XP_016874879.1
,
NP_001107654.1
,
NP_057207.2
,
XP_011536733.1
,
XP_005269004.1
,
XP_005269005.1
,
XP_011536734.1
,
XP_005269006.1
,
XP_011536735.1
,
XP_016874880.1
,
XP_005269000.1
,
NP_001138730.1
,
XP_005269001.1
,
XP_006719502.1
,
XP_005269002.1
,
NP_001138728.1
,
XP_006719501.1
,
NP_001138729.1
ZINC - World Drugs
IRAK4_HUMAN
Guide to Pharmacology - Targets
2045
OpenTargets
ENSG00000198001
ZINC - FDA approved
IRAK4_HUMAN
ZINC - Substances
IRAK4_HUMAN
ZINC - Biogenic
IRAK4_HUMAN
ZINC target
Q9NWZ3
PRO
Q9NWZ3
PDB
4YP8
,
2OIC
,
5KX8
,
6O8U
,
2OID
,
5K7I
,
5UIT
,
5UIS
,
5UIU
,
8DKS
,
6F3G
,
6VQL
,
2OIB
,
6F3E
,
2O8Y
,
5KX7
,
7QG5
,
6UYA
,
8ATL
,
8BR7
,
4ZTN
,
4RMZ
,
8ATN
,
5K75
,
8BR5
,
5K76
,
8BR6
,
5UIR
,
8ATB
,
6EGE
,
6LXY
,
6THW
,
7C2V
,
6EGD
,
7QG3
,
4U97
,
7QG2
,
5K72
,
6EGF
,
6F3I
,
6O94
,
5K7G
,
6RFJ
,
4XS2
,
6O95
,
6EGA
,
3MOP
,
6MOM
,
5T1T
,
5T1S
,
6N8G
,
6RFI
,
6EG9
,
2NRY
,
5UIQ
,
6TI8
,
4U9A
,
6TIA
,
6F3D
,
4Y73
,
5W84
,
2NRU
,
7QG1
,
6THZ
,
4ZTL
,
6O9D
,
4ZTM
,
6THX
,
7C2W
,
4YO6
,
5W85
,
8WTF
ZINC - Investigational
IRAK4_HUMAN
IntEnz
2.7.11.1
GeneCards
Q9NWZ3
HPA
ENSG00000198001-IRAK4
Ensembl
ENST00000440781
,
ENSP00000479889
,
ENST00000551736
,
ENSP00000446490
,
ENSP00000408734
,
ENST00000613694
,
ENSG00000198001
Pharos - Targets
Q9NWZ3
Orphanet
16266
ZINC - Predictions - Purchasable
IRAK4_HUMAN
HMDB Protein
HMDBP01466
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q99836 MYD88
8
MyD88 R196C [cytosol]
(R-HSA-5602329)
MyD88 E52del [cytosol]
(R-HSA-5602451)
MyD88 L93P [cytosol]
(R-HSA-5602612)
MyD88 S34Y [cytosol]
(R-HSA-5602521)
MyD88 E65del [cytosol]
(R-HSA-5602598)
MYD88 [endosome membrane]
(R-HSA-975123)
MYD88 [plasma membrane]
(R-HSA-937017)
MYD88 [cytosol]
(R-HSA-166059)
0.922
15
UniProt:Q96FA3 PELI1
2
PELI1 [cytosol]
(R-HSA-450696)
p-PELI1 [cytosol]
(R-HSA-450815)
0.775
6
UniProt:Q99836-1 MYD88
0.75
9
UniProt:O43187 IRAK2
6
IRAK2 [endosome membrane]
(R-HSA-975116)
p-IRAK2 [endosome membrane]
(R-HSA-975187)
IRAK2 [plasma membrane]
(R-HSA-937014)
IRAK2 [cytosol]
(R-HSA-772534)
p-IRAK2 [plasma membrane]
(R-HSA-936949)
p-IRAK2 [cytosol]
(R-HSA-446636)
0.711
6
UniProt:Q9HAT8 PELI2
2
PELI2 [cytosol]
(R-HSA-450694)
p-PELI2 [cytosol]
(R-HSA-450825)
0.593
3
UniProt:P0DPA2 VSIG8
0.589
2
UniProt:Q9UBH0 IL36RN
1
IL36RN [extracellular region]
(R-HSA-8940995)
0.556
3
UniProt:Q96LX8 ZNF597
1
ZNF597 [nucleoplasm]
(R-HSA-2127591)
0.556
3
UniProt:Q9C029 TRIM7
0.556
3
UniProt:P51617 IRAK1
14
K63polyUb-hp-IRAK1 [endosome membrane]
(R-HSA-975112)
p-S376,T387-IRAK1 [cytosol]
(R-HSA-446687)
p-S,T-IRAK1 [cytosol]
(R-HSA-3149574)
K63polyUb-hp-IRAK1 [cytosol]
(R-HSA-451565)
p-T209-IRAK1 [endosome membrane]
(R-HSA-975189)
p-T209,T387-IRAK1 [endosome membrane]
(R-HSA-975117)
IRAK1 [endosome membrane]
(R-HSA-975127)
p-2S,S376,T,T209,T387-IRAK1 [endosome membrane]
(R-HSA-975157)
IRAK1 [plasma membrane]
(R-HSA-937045)
p-T209-IRAK1 [plasma membrane]
(R-HSA-937031)
p-T209,T387-IRAK1 [plasma membrane]
(R-HSA-166279)
p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]
(R-HSA-937011)
p-2S,S376,T,T209,T387-IRAK1 [cytosol]
(R-HSA-446682)
IRAK1 [cytosol]
(R-HSA-446639)
0.547
2
UniProt:P58753 TIRAP
2
TIRAP [cytosol]
(R-HSA-166141)
p-4Y-TIRAP [plasma membrane]
(R-HSA-2201321)
0.499
2
UniProt:Q15109 AGER
1
AGER [plasma membrane]
(R-HSA-197639)
0.462
4
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