Reactome | p-T342,T345,S346-IRAK4 [cytosol]

p-T342,T345,S346-IRAK4 [cytosol]

Stable Identifier

R-HSA-446649

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Activated IRAK4

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Locations in the PathwayBrowser for interactor UniProt:Q15109 AGER

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External Reference Information

External Reference

UniProt:Q9NWZ3 IRAK4

Gene Names

IRAK4

Chain

chain:1-460

Reference Genes

BioGPS Gene:51135 IRAK4

COSMIC (genes):IRAK4 IRAK4

CTD Gene:51135 IRAK4

dbSNP Gene:51135 IRAK4

ENSEMBL:ENSG00000198001 IRAK4

ENSEMBL_homo_sapiens_GENE:ENSG00000198001.16 IRAK4

HGNC:17967 IRAK4

KEGG Gene (Homo sapiens):51135 IRAK4

Monarch:51135 IRAK4

NCBI Gene:51135 IRAK4

OMIM:606883 IRAK4

UCSC:Q9NWZ3 IRAK4

Reference Transcript

Other Identifiers

11734066_x_at

11734067_a_at

11740649_a_at

11742042_a_at

16750277

219618_3p_at

219618_PM_at

219618_at

3412297

3412299

3412302

3412306

3412307

3412308

3412309

3412311

3412316

3412317

3412318

3412320

3412321

3412322

3412323

3412324

3412325

3412326

3412327

3412328

3412329

3412330

51135

7954969

81368_at

A_23_P13978

A_24_P158903

GE58687

GE595587

GO:0000166

GO:0000287

GO:0002224

GO:0002376

GO:0002446

GO:0002755

GO:0003824

GO:0004672

GO:0004674

GO:0005149

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005768

GO:0005829

GO:0005886

GO:0006468

GO:0006950

GO:0007165

GO:0007254

GO:0008063

GO:0009986

GO:0010008

GO:0016301

GO:0016310

GO:0016740

GO:0019221

GO:0019897

GO:0019901

GO:0023052

GO:0031349

GO:0031410

GO:0032103

GO:0034142

GO:0034162

GO:0035556

GO:0036211

GO:0038172

GO:0043123

GO:0043226

GO:0045087

GO:0048661

GO:0048870

GO:0070498

GO:0071222

GO:0071310

GO:0098542

GO:0106310

GO:0140096

GO:1990266

HMNXSV003043621

ILMN_1692352

TC12000325.hg

g7705840_3p_x_at

Participates

as an output of

TRAF6 binding leads to IRAK1:TRAF6 release (Homo sapiens)

as a component of

IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Homo sapiens)

Other forms of this molecule

IRAK4 Q293* [cytosol]

IRAK4 R12C [cytosol]

IRAK4 E402* [cytosol]

IRAK4 [endosome membrane]

p-T342,T345,S346-IRAK4 [endosome membrane]

IRAK4 [plasma membrane]

p-T342,T345,S346-IRAK4 [plasma membrane]

IRAK4 [cytosol]

Inferred To

Ghost homologue of p-T342,T345,S346-IRAK4 [cytosol] (Gallus gallus)

Ghost homologue of p-T342,T345,S346-IRAK4 [cytosol] (Xenopus tropicalis)

phospho-p-T342,T345,S346-IRAK4 [cytosol] (Bos taurus)

phospho-p-T342,T345,S346-IRAK4 [cytosol] (Mus musculus)

phospho-p-T342,T345,S346-IRAK4 [cytosol] (Rattus norvegicus)

phospho-p-T342,T345,S346-IRAK4 [cytosol] (Sus scrofa)

phospho-IRAK4 [cytosol] (Canis familiaris)

Modified Residues

Name

O-phospho-L-threonine at 342

Coordinate

342

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-threonine at 345

Coordinate

345

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 346

Coordinate

346

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

XP_016874879.1, NP_001107654.1, NP_057207.2, XP_011536733.1, XP_005269004.1, XP_005269005.1, XP_011536734.1, XP_005269006.1, XP_011536735.1, XP_016874880.1, XP_005269000.1, NP_001138730.1, XP_005269001.1, XP_006719502.1, XP_005269002.1, NP_001138728.1, XP_006719501.1, NP_001138729.1

ZINC - World Drugs

IRAK4_HUMAN

Guide to Pharmacology - Targets

2045

OpenTargets

ENSG00000198001

ZINC - FDA approved

IRAK4_HUMAN

ZINC - Substances

IRAK4_HUMAN

ZINC - Biogenic

IRAK4_HUMAN

ZINC target

Q9NWZ3

PRO

Q9NWZ3

PDB

4YP8, 2OIC, 5KX8, 6O8U, 2OID, 5K7I, 5UIT, 5UIS, 5UIU, 8DKS, 6F3G, 6VQL, 2OIB, 6F3E, 2O8Y, 5KX7, 7QG5, 6UYA, 8ATL, 8BR7, 4ZTN, 4RMZ, 8ATN, 5K75, 8BR5, 5K76, 8BR6, 5UIR, 8ATB, 6EGE, 6LXY, 6THW, 7C2V, 6EGD, 7QG3, 4U97, 7QG2, 5K72, 6EGF, 6F3I, 6O94, 5K7G, 6RFJ, 4XS2, 6O95, 6EGA, 3MOP, 6MOM, 5T1T, 5T1S, 6N8G, 6RFI, 6EG9, 2NRY, 5UIQ, 6TI8, 4U9A, 6TIA, 6F3D, 4Y73, 5W84, 2NRU, 7QG1, 6THZ, 4ZTL, 6O9D, 4ZTM, 6THX, 7C2W, 4YO6, 5W85, 8WTF

ZINC - Investigational

IRAK4_HUMAN

IntEnz

2.7.11.1

GeneCards

Q9NWZ3

HPA

ENSG00000198001-IRAK4

Ensembl

ENST00000440781, ENSP00000479889, ENST00000551736, ENSP00000446490, ENSP00000408734, ENST00000613694, ENSG00000198001

Pharos - Targets

Q9NWZ3

Orphanet

16266

ZINC - Predictions - Purchasable

IRAK4_HUMAN

HMDB Protein

HMDBP01466

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q99836 MYD88	8	MyD88 R196C [cytosol] (R-HSA-5602329) MyD88 E52del [cytosol] (R-HSA-5602451) MyD88 L93P [cytosol] (R-HSA-5602612) MyD88 S34Y [cytosol] (R-HSA-5602521) MyD88 E65del [cytosol] (R-HSA-5602598) MYD88 [endosome membrane] (R-HSA-975123) MYD88 [plasma membrane] (R-HSA-937017) MYD88 [cytosol] (R-HSA-166059)	0.922	15
UniProt:Q96FA3 PELI1	2	PELI1 [cytosol] (R-HSA-450696) p-PELI1 [cytosol] (R-HSA-450815)	0.775	6
UniProt:Q99836-1 MYD88			0.75	9
UniProt:O43187 IRAK2	6	IRAK2 [endosome membrane] (R-HSA-975116) p-IRAK2 [endosome membrane] (R-HSA-975187) IRAK2 [plasma membrane] (R-HSA-937014) IRAK2 [cytosol] (R-HSA-772534) p-IRAK2 [plasma membrane] (R-HSA-936949) p-IRAK2 [cytosol] (R-HSA-446636)	0.711	6
UniProt:Q9HAT8 PELI2	2	PELI2 [cytosol] (R-HSA-450694) p-PELI2 [cytosol] (R-HSA-450825)	0.593	3
UniProt:P0DPA2 VSIG8			0.589	2
UniProt:Q9UBH0 IL36RN	1	IL36RN [extracellular region] (R-HSA-8940995)	0.556	3
UniProt:Q96LX8 ZNF597	1	ZNF597 [nucleoplasm] (R-HSA-2127591)	0.556	3
UniProt:Q9C029 TRIM7			0.556	3
UniProt:P51617 IRAK1	14	K63polyUb-hp-IRAK1 [endosome membrane] (R-HSA-975112) p-S376,T387-IRAK1 [cytosol] (R-HSA-446687) p-S,T-IRAK1 [cytosol] (R-HSA-3149574) K63polyUb-hp-IRAK1 [cytosol] (R-HSA-451565) p-T209-IRAK1 [endosome membrane] (R-HSA-975189) p-T209,T387-IRAK1 [endosome membrane] (R-HSA-975117) IRAK1 [endosome membrane] (R-HSA-975127) p-2S,S376,T,T209,T387-IRAK1 [endosome membrane] (R-HSA-975157) IRAK1 [plasma membrane] (R-HSA-937045) p-T209-IRAK1 [plasma membrane] (R-HSA-937031) p-T209,T387-IRAK1 [plasma membrane] (R-HSA-166279) p-2S,S376,T,T209,T387-IRAK1 [plasma membrane] (R-HSA-937011) p-2S,S376,T,T209,T387-IRAK1 [cytosol] (R-HSA-446682) IRAK1 [cytosol] (R-HSA-446639)	0.547	2
UniProt:P58753 TIRAP	2	TIRAP [cytosol] (R-HSA-166141) p-4Y-TIRAP [plasma membrane] (R-HSA-2201321)	0.499	2
UniProt:Q15109 AGER	1	AGER [plasma membrane] (R-HSA-197639)	0.462	4

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