p-2S,S376,T,T209,T387-IRAK1 [cytosol]

Stable Identifier
R-HSA-446682
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-6T-IRAK1, hp-IRAK1, Interleukin-1 receptor-associated kinase 1, IRAK1_HUMAN, IRAK1
Icon
p-2S,S376,T,T209,T387-IRAK1 [cytosol] icon
p-2S,S376,T,T209,T387-IRAK1 [cytosol] icon
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:P51617 IRAK1
Gene Names
IRAK1, IRAK
Chain
chain:1-712
Reference Genes
BioGPS Gene:3654 IRAK1
COSMIC (genes):IRAK1 IRAK1
CTD Gene:3654 IRAK1
dbSNP Gene:3654 IRAK1
ENSEMBL:ENSG00000184216 IRAK1
ENSEMBL:ENSG00000184216.15 IRAK1
HGNC:6112 IRAK1
KEGG Gene (Homo sapiens):3654 IRAK1
Monarch:3654 IRAK1
NCBI Gene:3654 IRAK1
OMIM:300283 IRAK1
UCSC:P51617 IRAK1
Reference Transcript
Other Identifiers
1100_at
11734006_a_at
1555784_PM_s_at
1555784_s_at
17115428
201587_PM_s_at
201587_s_at
3654
4027010
4027011
4027012
4027013
4027014
4027015
4027016
4027017
4027018
4027021
4027022
4027023
4027024
4027027
4027028
4027029
4027031
4027033
4027034
4027037
4027038
4027040
4027041
4027043
4027045
4027046
4027048
4027050
4027051
4027052
4027053
8175977
A_23_P73780
A_33_P3286616
GE62370
GO:0000166
GO:0001959
GO:0002224
GO:0002376
GO:0002755
GO:0003824
GO:0004672
GO:0004674
GO:0004704
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005811
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006468
GO:0007155
GO:0007165
GO:0007250
GO:0007254
GO:0009986
GO:0010008
GO:0010556
GO:0016301
GO:0016310
GO:0016740
GO:0019221
GO:0019901
GO:0023052
GO:0031072
GO:0031326
GO:0031410
GO:0031663
GO:0032088
GO:0032481
GO:0032496
GO:0032991
GO:0034134
GO:0034142
GO:0034162
GO:0034605
GO:0035556
GO:0036211
GO:0042802
GO:0042803
GO:0043123
GO:0043226
GO:0043406
GO:0044093
GO:0045087
GO:0046777
GO:0046982
GO:0048583
GO:0048661
GO:0051092
GO:0060337
GO:0070498
GO:0070555
GO:0071222
GO:0071345
GO:0071456
GO:0098542
GO:0098772
GO:0106310
GO:0140096
GO:1901224
GO:1904996
HMNXSV003048644
HMNXSV003053546
Hs2.182018.3.S1_3p_s_at
ILMN_2379130
L76191_at
PH_hs_0010754
TC0X001524.hg
g4755143_3p_s_at
Participates
as a member of
as a component of
Other forms of this molecule
p-S376,T387-IRAK1 [cytosol]
K63polyUb-hp-IRAK1 [endosome membrane]
p-S,T-IRAK1 [cytosol]
K63polyUb-hp-IRAK1 [cytosol]
p-T209-IRAK1 [endosome membrane]
p-T209,T387-IRAK1 [endosome membrane]
IRAK1 [endosome membrane]
p-2S,S376,T,T209,T387-IRAK1 [endosome membrane]
IRAK1 [plasma membrane]
p-T209-IRAK1 [plasma membrane]
p-T209,T387-IRAK1 [plasma membrane]
p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]
IRAK1 [cytosol]
Inferred To
phospho-p-2S,S376,T,T209,T387-IRAK1 [cytosol] (Bos taurus)
phospho-p-2S,S376,T,T209,T387-IRAK1 [cytosol] (Caenorhabditis elegans)
phospho-p-2S,S376,T,T209,T387-IRAK1 [cytosol] (Canis familiaris)
phospho-p-2S,S376,T,T209,T387-IRAK1 [cytosol] (Danio rerio)
phospho-p-2S,S376,T,T209,T387-IRAK1 [cytosol] (Dictyostelium discoideum)
phospho-p-2S,S376,T,T209,T387-IRAK1 [cytosol] (Drosophila melanogaster)
phospho-p-2S,S376,T,T209,T387-IRAK1 [cytosol] (Mus musculus)
phospho-p-2S,S376,T,T209,T387-IRAK1 [cytosol] (Rattus norvegicus)
phospho-p-2S,S376,T,T209,T387-IRAK1 [cytosol] (Saccharomyces cerevisiae)
phospho-p-2S,S376,T,T209,T387-IRAK1 [cytosol] (Schizosaccharomyces pombe)
phospho-p-2S,S376,T,T209,T387-IRAK1 [cytosol] (Sus scrofa)
Homologues of p-2S,S376,T,T209,T387-IRAK1 [cytosol] (Saccharomyces cerevisiae)
Ghost homologue of p-2S,S376,T,T209,T387-IRAK1 [cytosol] (Gallus gallus)
Ghost homologue of p-2S,S376,T,T209,T387-IRAK1 [cytosol] (Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-threonine at 387
Coordinate
387
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 376
Coordinate
376
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 209
Coordinate
209
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at unknown position
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
PDB
ZINC - Investigational
GeneCards
HPA
Ensembl
Pharos - Targets
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
Interactors (21)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q9HAT8 PELI2  2 0.743 4
 UniProt:Q96FA3 PELI1  2 0.734 4
 UniProt:Q9Y4K3 TRAF6  8 0.702 3
 UniProt:Q13526 PIN1  2 0.645 10
 UniProt:Q99836 MYD88  8 0.641 3
 UniProt:Q8N2H9-2 PELI3      0.589 2
 UniProt:Q9Y616 IRAK3  1 0.564 3
 UniProt:O43187 IRAK2  6 0.564 3
 UniProt:Q9NWZ3 IRAK4  9 0.547 2
 UniProt:Q5D1E7  1 0.544 3
 UniProt:Q9UNE7 STUB1  1 0.527 2
 UniProt:P31689 DNAJA1  1 0.527 2
 UniProt:P50402 EMD  4 0.527 2
 UniProt:O15027 SEC16A  1 0.527 2
 UniProt:O60884 DNAJA2  1 0.527 2
 UniProt:Q96EY1 DNJA3      0.527 2
 UniProt:Q92985 IRF7  5 0.499 2
 UniProt:P58753 TIRAP  2 0.499 2
 UniProt:Q86WV6 STING1  5 0.499 2
 UniProt:Q8VCW4  2 0.499 2
 UniProt:Q15306 IRF4  1 0.499 2
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