NrCAM interactions

Stable Identifier
R-HSA-447038
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Pathway
Species
Homo sapiens
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The NgCAM-related cell adhesion molecule (NrCAM) is member of the L1 family involved in the eye development and node of Ranvier. Like all the other members of L1 family NrCAM also has the ability to bind to ankyrins. The last C-terminal amino acids of NrCAM form a PDZ-binding motif and can interact with SAP (synapse-associated protein) 102 and SAP97. Member of the GPI-anchored TAG-1/axonin-1 have been shown to interact with NrCAM. NrCAM also binds the Sema3B receptor NP-2 to mediate repulsive axon guidance.

Literature References
PubMed ID Title Journal Year
10662501 Structural and functional evolution of the L1 family: are four adhesion molecules better than one?

Hortsch, M

Mol Cell Neurosci 2000
16202709 Dual functional activity of semaphorin 3B is required for positioning the anterior commissure

Falk, J, Bechara, A, Fiore, R, Nawabi, H, Zhou, H, Hoyo-Becerra, C, Bozon, M, Rougon, G, Grumet, M, PĆ¼schel, AW, Sanes, JR, Castellani, V

Neuron 2005
19356150 The intracellular interactions of the L1 family of cell adhesion molecules

Herron, LR, Hill, M, Davey, F, Gunn-Moore, FJ

Biochem J 2009
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