Reactome: A Curated Pathway Database

NrCAM interactions

Stable Identifier
R-HSA-447038
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The NgCAM-related cell adhesion molecule (NrCAM) is member of the L1 family involved in the eye development and node of Ranvier. Like all the other members of L1 family NrCAM also has the ability to bind to ankyrins. The last C-terminal amino acids of NrCAM form a PDZ-binding motif and can interact with SAP (synapse-associated protein) 102 and SAP97. Member of the GPI-anchored TAG-1/axonin-1 have been shown to interact with NrCAM. NrCAM also binds the Sema3B receptor NP-2 to mediate repulsive axon guidance.

Literature References
Participants
Participant Of