Neurofascin interactions

Stable Identifier
R-HSA-447043
Type
Pathway
Species
Homo sapiens
Compartment
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Summation

Neurofascin is an L1 family immunoglobulin cell adhesion molecule involved in axon subcellular targeting and synapse formation during neural development. There are a range of different isoforms identified in Neurofascin of which two of them are well studied the 186kDa commonly referred to as neuronal form and is present in node of Ranvier neurons and the 155kDa form known as a glial form present in schwann cells.
Neurofascin colocalizes with NrCAM and ankyrinG at the nodes of Ranvier. Neurofascin participates in transheterophilic adhesion with NrCAM and stimulates neurite outgrowth in chicken tectal neurons. The last few amino acids of neurofascin form the PDZ class I binding motif (SLA) and through these last few amino acids it associates with syntenin-1.

Literature References
PubMed ID Title Journal Year
19356150 The intracellular interactions of the L1 family of cell adhesion molecules

Herron, LR, Hill, M, Davey, F, Gunn-Moore, FJ

Biochem J 2009
10662501 Structural and functional evolution of the L1 family: are four adhesion molecules better than one?

Hortsch, M

Mol Cell Neurosci 2000
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