AMPK phosphorylates Raptor in the mTORC1 complex

Stable Identifier
R-HSA-447074
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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AMPK phosphorylates Raptor in the mTORC1 complex
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Activated AMPK (phosphorylated on Thr172 or Thr174 and AMP bound) phosphorylates RPTOR (Raptor) on Ser722 and Ser792. These phosphorylations are required for inhibition of mTORC1 activity in response to energy stress (Gwinn et al. 2008).

Literature References
PubMed ID Title Journal Year
18439900 AMPK phosphorylation of raptor mediates a metabolic checkpoint

Mihaylova, MM, Mery, A, Shaw, RJ, Turk, BE, Vasquez, DS, Gwinn, DM, Egan, DF, Shackelford, DB

Mol Cell 2008
Participants
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Output
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as an event of
Catalyst Activity

AMP-activated protein kinase activity of p-AMPK heterotrimer:AMP [cytosol]

Physical Entity
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
Activity
AMP-activated protein kinase activity (GO:0004679)
Orthologous Events
AMPK phosphorylates Raptor in the mTORC1 complex (Bos taurus)
AMPK phosphorylates Raptor in the mTORC1 complex (Caenorhabditis elegans)
AMPK phosphorylates Raptor in the mTORC1 complex (Canis familiaris)
AMPK phosphorylates Raptor in the mTORC1 complex (Danio rerio)
AMPK phosphorylates Raptor in the mTORC1 complex (Dictyostelium discoideum)
AMPK phosphorylates Raptor in the mTORC1 complex (Drosophila melanogaster)
AMPK phosphorylates Raptor in the mTORC1 complex (Gallus gallus)
AMPK phosphorylates Raptor in the mTORC1 complex (Mus musculus)
AMPK phosphorylates Raptor in the mTORC1 complex (Rattus norvegicus)
AMPK phosphorylates Raptor in the mTORC1 complex (Sus scrofa)
Authored
Makela, T  (2010-02-03)
Katajisto, P  (2010-02-03)
Wu, J  (2010-02-03)
Reviewed
Zwartkruis, FJ  (2015-05-14)
Created
Jassal, B  (2009-11-20)
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