AMPK phosphorylates Raptor in the mTORC1 complex

Stable Identifier
R-HSA-447074
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Activated AMPK (phosphorylated on Thr172 or Thr174 and AMP bound) phosphorylates RPTOR (Raptor) on Ser722 and Ser792. These phosphorylations are required for inhibition of mTORC1 activity in response to energy stress (Gwinn et al. 2008).

Literature References
PubMed ID Title Journal Year
18439900 AMPK phosphorylation of raptor mediates a metabolic checkpoint

Gwinn, DM, Shackelford, DB, Egan, DF, Mihaylova, MM, Mery, A, Vasquez, DS, Turk, BE, Shaw, RJ

Mol Cell 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
AMP-activated protein kinase activity of p-AMPK heterotrimer:AMP [cytosol]
Physical Entity
Activity
Orthologous Events
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