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IL7 [extracellular region]
Stable Identifier
R-HSA-447209
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Interleukin-7, IL7_HUMAN, lymphopoietin 1, pre-B cell factor
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-7 signaling (Homo sapiens)
IL7 binds HGF(495-728) to form PPBSF (Homo sapiens)
HGF(495-728):IL7 [extracellular region] (Homo sapiens)
IL7 [extracellular region] (Homo sapiens)
IL7 [extracellular region] (Homo sapiens)
IL7 binds IL7R:JAK1 (Homo sapiens)
IL7 [extracellular region] (Homo sapiens)
IL7:IL7R:JAK1 [plasma membrane] (Homo sapiens)
IL7 [extracellular region] (Homo sapiens)
IL7:IL7R:JAK1 binds IL2RG:JAK3 (Homo sapiens)
IL7:IL7R:JAK1 [plasma membrane] (Homo sapiens)
IL7 [extracellular region] (Homo sapiens)
IL7:IL7R:JAK1:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL7:IL7R:JAK1 [plasma membrane] (Homo sapiens)
IL7 [extracellular region] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1 [plasma membrane] (Homo sapiens)
IL7 [extracellular region] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:p-FYN:IL2RG:JAK3:PI3K-regulatory subunits [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1 [plasma membrane] (Homo sapiens)
IL7 [extracellular region] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits:IRS1,IRS2 [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:p-FYN:IL2RG:JAK3:PI3K-regulatory subunits [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1 [plasma membrane] (Homo sapiens)
IL7 [extracellular region] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:p-FYN:IL2RG:JAK3:PI3K-regulatory subunits [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1 [plasma membrane] (Homo sapiens)
IL7 [extracellular region] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1 [plasma membrane] (Homo sapiens)
IL7 [extracellular region] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1 [plasma membrane] (Homo sapiens)
IL7 [extracellular region] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1 [plasma membrane] (Homo sapiens)
IL7 [extracellular region] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1 [plasma membrane] (Homo sapiens)
IL7 [extracellular region] (Homo sapiens)
IL7R is phosphorylated on Y499 (Homo sapiens)
IL7:IL7R:JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL7:IL7R:JAK1 [plasma membrane] (Homo sapiens)
IL7 [extracellular region] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1 [plasma membrane] (Homo sapiens)
IL7 [extracellular region] (Homo sapiens)
JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Homo sapiens)
IL7:IL7R:JAK1:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL7:IL7R:JAK1 [plasma membrane] (Homo sapiens)
IL7 [extracellular region] (Homo sapiens)
IL7:IL7R:JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL7:IL7R:JAK1 [plasma membrane] (Homo sapiens)
IL7 [extracellular region] (Homo sapiens)
p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1 [plasma membrane] (Homo sapiens)
IL7 [extracellular region] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1 [plasma membrane] (Homo sapiens)
IL7 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P13232 IL7
Gene Names
IL7
Chain
signal peptide:1-25, chain:26-177
Reference Genes
BioGPS Gene:3574 IL7
COSMIC (genes):IL7 IL7
CTD Gene:3574 IL7
dbSNP Gene:3574 IL7
ENSEMBL:ENSG00000104432 IL7
HGNC:6023 IL7
KEGG Gene (Homo sapiens):3574 IL7
Monarch:3574 IL7
NCBI Gene:3574 IL7
OMIM:146660 IL7
UCSC:P13232 IL7
Reference Transcript
RefSeq:NM_001199888.1 IL7
RefSeq:NM_001199886.1 IL7
RefSeq:NM_000880.3 IL7
RefSeq:NM_001199887.1 IL7
Other Identifiers
1159_at
11735257_a_at
11735258_x_at
11747034_a_at
11747035_a_at
11754162_a_at
11754163_x_at
17078434
206693_at
3141605
3141606
3141607
3141608
3141609
3141610
3141611
3141612
3141621
3141622
3141623
3141629
33966_at
3574
8151447
A_23_P8961
GE60509
GO:0001961
GO:0002360
GO:0002376
GO:0003674
GO:0005125
GO:0005126
GO:0005139
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0006464
GO:0006955
GO:0006959
GO:0007155
GO:0007165
GO:0007267
GO:0008083
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0009887
GO:0010468
GO:0010628
GO:0019221
GO:0030154
GO:0030890
GO:0031012
GO:0032722
GO:0038111
GO:0040007
GO:0042592
GO:0043066
GO:0043086
GO:0045453
GO:0045579
GO:0045582
GO:0046622
GO:0048856
GO:0048873
GO:0050730
GO:0062023
GO:2001237
GO:2001240
ILMN_2059744
J04156_at
PH_hs_0004192
g4504676_3p_at
Participant Of
hasComponent
HGF(495-728):IL7 [extracellular region]
IL7:IL7R:JAK1 [plasma membrane]
IL7:p-Y449-IL7R:JAK1 [plasma membrane]
PPBSF (chimeric) [extracellular region]
input
IL7 binds HGF(495-728) to form PPBSF
IL7 binds IL7R:JAK1
PPBSF is a complex of Il7 and Hgf(495-728)
Inferred To
Ghost homologue of IL7 [extracellular region] (Canis familiaris)
Ghost homologue of IL7 [extracellular region] (Danio rerio)
Ghost homologue of IL7 [extracellular region] (Mus musculus)
Ghost homologue of IL7 [extracellular region] (Rattus norvegicus)
Ghost homologue of IL7 [extracellular region] (Sus scrofa)
Cross References
RefSeq
NP_001186817.1
,
NP_001186815.1
,
NP_001186816.1
,
NP_000871.1
OpenTargets
ENSG00000104432
HPA
ENSG00000104432-IL7
GeneCards
P13232
Ensembl
ENSG00000104432
,
ENST00000263851
,
ENSP00000263851
,
ENST00000520269
,
ENSP00000427750
PRO
P13232
Orphanet
27944
PDB
3DI2
,
3DI3
,
1IL7
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P16871 IL7R
3
IL7R [plasma membrane]
(R-HSA-449945)
IL7R [clathrin-coated endocytic vesicle membrane]
(R-HSA-9028500)
p-Y449-IL7R [plasma membrane]
(R-HSA-1295531)
0.737
10
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