Reactome | IL13 [extracellular region]

IL13 [extracellular region]

Stable Identifier

R-HSA-447211

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Interleukin-13, IL13_HUMAN

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P35225 IL13

Gene Names

IL13, NC30

Chain

signal peptide:1-24, chain:25-146

Reference Genes

BioGPS Gene:3596 IL13

COSMIC (genes):IL13 IL13

CTD Gene:3596 IL13

dbSNP Gene:3596 IL13

ENSEMBL:ENSG00000169194 IL13

ENSEMBL_homo_sapiens_GENE:ENSG00000169194.10 IL13

HGNC:5973 IL13

KEGG Gene (Homo sapiens):3596 IL13

Monarch:3596 IL13

NCBI Gene:3596 IL13

OMIM:147683 IL13

UCSC:P35225 IL13

Reference Transcript

RefSeq:NM_002188.2 IL13

Other Identifiers

11735860_at

11745622_a_at

16989093

207844_PM_at

207844_at

2828692

2828693

2828694

2828695

2828696

2828697

2828698

3596

494_at

8107970

A_14_P119868

A_14_P200144

A_23_P251031

GE81131

GO:0001774

GO:0002376

GO:0002639

GO:0005125

GO:0005126

GO:0005144

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005886

GO:0006954

GO:0006955

GO:0007165

GO:0009612

GO:0009897

GO:0010155

GO:0010628

GO:0012501

GO:0016192

GO:0023052

GO:0030154

GO:0030890

GO:0032496

GO:0032723

GO:0032733

GO:0035094

GO:0036211

GO:0042116

GO:0042531

GO:0043032

GO:0043270

GO:0043306

GO:0045471

GO:0048018

GO:0048661

GO:0048856

GO:0050714

GO:0050728

GO:0051281

GO:0055065

GO:0055085

GO:0071260

GO:0071345

GO:0071635

GO:0098772

GO:0120162

GO:1901247

GO:1901251

GO:1903660

GO:2000231

GO:2000352

HMNXSV003020005

ILMN_2052511

PH_hs_0000101

TC05000640.hg

U31120_rna1_at

g4504644_3p_at

Participates

as a component of

as an input of

as a member of

IL4, IL13 [extracellular region] (Homo sapiens)

This entity regulates

Negatively

Expression of IL13-downregulated extracellular proteins (Homo sapiens)

Positively

Expression of IL13-upregulated plasma membrane proteins (Homo sapiens)

Inferred To

Il13 [extracellular region] (Mus musculus)

Il13 [extracellular region] (Rattus norvegicus)

IL13 [extracellular region] (Bos taurus)

IL13 [extracellular region] (Canis familiaris)

IL13 [extracellular region] (Sus scrofa)

Ghost homologue of IL13 [extracellular region] (Gallus gallus)

Cross References

RefSeq

NP_002179.2

OpenTargets

ENSG00000169194

GeneCards

P35225

HPA

ENSG00000169194-IL13

Ensembl

ENSG00000169194, ENST00000304506, ENSP00000304915

PRO

P35225

Pharos - Targets

P35225

PDB

1IJZ, 1GA3, 5E4E, 4I77, 3L5W, 1IK0, 3L5X, 3BPO, 3LB6, 4PS4, 3G6D, 5L6Y

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14627 IL13RA2	1	IL13RA2 [extracellular region] (R-HSA-449666)	0.802	9
UniProt:P78552 IL13RA1	2	IL13RA1 [plasma membrane] (R-HSA-449671) p-Y-IL13RA1 [plasma membrane] (R-HSA-6786750)	0.74	6