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IL12RB1 [plasma membrane]
Stable Identifier
R-HSA-447227
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Interleukin-12 receptor beta-1 chain, I12R1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-12 signaling (Homo sapiens)
IL12 bound to IL12R internalises (Homo sapiens)
IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [cytosol] (Homo sapiens)
IL12RB1:TYK2:IL12RB2:JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:TYK2 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:TYK2:IL12RB2:JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:TYK2 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
IL12RB1 binds TYK2 (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
IL12RB1:TYK2 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
IL12RB1:TYK2 binds IL12RB2:JAK2 (Homo sapiens)
IL12RB1:TYK2 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
IL12RB1:TYK2:IL12RB2:JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:TYK2 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
p-Y800-IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:JAK1 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
Interleukin-12 binds Interleukin-12 receptor (Homo sapiens)
IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:TYK2:IL12RB2:JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:TYK2 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
IL12RB1:TYK2:IL12RB2:JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:TYK2 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
Interleukin-12 dissociates from Interleukin-12 receptor (Homo sapiens)
IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:TYK2:IL12RB2:JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:TYK2 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
IL12RB1:TYK2:IL12RB2:JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:TYK2 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:TYK2:IL12RB2:JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:TYK2 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
p-Y800-IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:JAK1 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2:2xSTAT4 [plasma membrane] (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
p-Y800-IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:JAK1 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction (Homo sapiens)
2xp-Y693-STAT4:IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
p-Y800-IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:JAK1 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2:2xSTAT4 [plasma membrane] (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
p-Y800-IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:JAK1 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
p-Y693-STAT4 dissociates after IL12:IL12R interaction (Homo sapiens)
2xp-Y693-STAT4:IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
p-Y800-IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:JAK1 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
Interleukin-23 signaling (Homo sapiens)
IL23R in IL23:IL23 receptor complex is phosphorylated (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:TYK2 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
Interleukin-23 binds interleukin-23 receptor (Homo sapiens)
IL12RB1:TYK2 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 [plasma membrane] (Homo sapiens)
IL12RB1:TYK2 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 [plasma membrane] (Homo sapiens)
IL12RB1:TYK2 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
STAT3 binds to p-Y-IL23R in IL23:IL23 receptor (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:TYK2 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:TYK2 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3:STAT4 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:TYK2 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:p-Y705-STAT3:p-Y693-STAT4 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:TYK2 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:TYK2 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3:STAT4 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:TYK2 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:TYK2 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:p-Y705-STAT3:p-Y693-STAT4 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12RB1:TYK2 [plasma membrane] (Homo sapiens)
IL12RB1 [plasma membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
25516297
IL12Rβ1: the cytokine receptor that we used to know
Robinson, RT
Cytokine
2015
External Reference Information
External Reference
UniProt:P42701 IL12RB1
Gene Names
IL12RB1, IL12R, IL12RB
Chain
signal peptide:1-23, chain:24-662
Reference Genes
BioGPS Gene:3594 IL12RB1
COSMIC (genes):IL12RB1 IL12RB1
CTD Gene:3594 IL12RB1
dbSNP Gene:3594 IL12RB1
ENSEMBL:ENSG00000096996 IL12RB1
ENSEMBL_homo_sapiens_GENE:ENSG00000096996.16 IL12RB1
HGNC:5971 IL12RB1
KEGG Gene (Homo sapiens):3594 IL12RB1
Monarch:3594 IL12RB1
NCBI Gene:3594 IL12RB1
OMIM:601604 IL12RB1
UCSC:P42701 IL12RB1
Reference Transcript
RefSeq:NM_153701.2 IL12RB1
RefSeq:NM_001290023.1 IL12RB1
RefSeq:NM_005535.2 IL12RB1
Other Identifiers
1066_at
11741270_x_at
11752440_a_at
11759434_at
1552584_PM_at
1552584_at
16870309
206890_PM_at
206890_at
239522_PM_at
239522_at
3594
3854698
3854699
3854702
3854703
3854704
3854705
3854706
3854707
3854708
3854709
3854710
3854711
3854713
3854714
3854716
3854717
3854718
3854719
3854720
3854721
3854722
3854724
3854725
3854726
72852_at
8035380
A_23_P101783
A_23_P399156
GE58862
GO:0001916
GO:0002230
GO:0002376
GO:0002827
GO:0004896
GO:0005143
GO:0005515
GO:0005886
GO:0007155
GO:0007165
GO:0009897
GO:0016020
GO:0016517
GO:0019221
GO:0019955
GO:0023052
GO:0030154
GO:0032729
GO:0035722
GO:0038155
GO:0042019
GO:0042020
GO:0042022
GO:0042104
GO:0043235
GO:0043382
GO:0048856
GO:0060089
GO:0071346
GO:0072536
GO:0098542
GO:2000318
GO:2000330
HMNXSV003049935
Hs.223894.0.A1_3p_at
Hs.223894.0.A1_3p_x_at
Hs2.121544.1.S1_3p_at
ILMN_1699908
ILMN_1789645
ILMN_1815890
PH_hs_0012528
TC19001281.hg
U03187_at
g5031784_3p_at
Participates
as a component of
IL12RB1:JAK1 [plasma membrane] (Homo sapiens)
IL12RB1:p-Y-TYK2 [plasma membrane] (Homo sapiens)
IL12RB1:TYK2 [plasma membrane] (Homo sapiens)
as an input of
IL12RB1 binds TYK2 (Homo sapiens)
Inferred To
Ghost homologue of IL12RB1 [plasma membrane]
(Xenopus tropicalis)
IL12RB1 [plasma membrane]
(Bos taurus)
IL12RB1 [plasma membrane]
(Canis familiaris)
IL12RB1 [plasma membrane]
(Gallus gallus)
IL12RB1 [plasma membrane]
(Sus scrofa)
Il12rb1 [plasma membrane]
(Mus musculus)
Il12rb1 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_714912.1
,
NP_005526.1
,
NP_001276952.1
Guide to Pharmacology - Targets
1715
OpenTargets
ENSG00000096996
HPA
ENSG00000096996-IL12RB1
GeneCards
P42701
Ensembl
ENST00000593993
,
ENSP00000314425
,
ENSP00000470788
,
ENST00000322153
,
ENST00000600835
,
ENSG00000096996
,
ENSP00000472165
PRO
P42701
Pharos - Targets
P42701
Orphanet
16255
PDB
6WDP
,
6WDQ
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