IL12RB1:TYK2 binds IL12RB2:JAK2

Stable Identifier
R-HSA-447252
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
Synonyms
Interleukin-12 receptor B1 binds Interleukin-12 receptor B2 forming Interleukin-12 receptor
ReviewStatus
5/5
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IL12RB1:TYK2 binds IL12RB2:JAK2
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Interleukin-12 receptor beta 2 (IL12RB2) is a type I transmembrane protein with a 595-amino-acid-long extracellular domain and a cytoplasmic tail of 216 amino acids that contains three tyrosine residues. It binds Interleukin-12 with low affinity. IL12RB2 binds Interleukin 12 receptor beta 1 subunit (IL12RB1) forming the high affinity Interleukin-12 receptor (Presky et al. 1996a, 1996b), which signals via JAK2 and TYK2 (Zou et al. 1997).
Literature References
PubMed ID Title Journal Year
8943050 A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits

Presky, DH, Minetti, LJ, Yang, H, Gately, MK, Gubler, U, Nabavi, N, Chua, AO, Wu, CY

Proc Natl Acad Sci U S A 1996
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Orthologous Events
IL12RB1:TYK2 binds IL12RB2:JAK2 (Bos taurus)
IL12RB1:TYK2 binds IL12RB2:JAK2 (Canis familiaris)
IL12RB1:TYK2 binds IL12RB2:JAK2 (Gallus gallus)
IL12RB1:TYK2 binds IL12RB2:JAK2 (Mus musculus)
IL12RB1:TYK2 binds IL12RB2:JAK2 (Rattus norvegicus)
IL12RB1:TYK2 binds IL12RB2:JAK2 (Sus scrofa)
Authored
Jupe, S  (2014-06-04)
Reviewed
Meldal, BH  (2016-01-28)
Created
Jupe, S  (2009-11-20)
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