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IL18 [extracellular region]
Stable Identifier
R-HSA-448446
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
IL18(37-193), Interleukin-18
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Cell recruitment (pro-inflammatory response) (Homo sapiens)
Purinergic signaling in leishmaniasis infection (Homo sapiens)
Interleukin-1 family are secreted (Homo sapiens)
Interleukin-1 family [extracellular region] (Homo sapiens)
IL18 [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 processing (Homo sapiens)
Interleukin-1 family are secreted (Homo sapiens)
Interleukin-1 family [extracellular region] (Homo sapiens)
IL18 [extracellular region] (Homo sapiens)
Interleukin-18 signaling (Homo sapiens)
IL18 binds IL18R1 (Homo sapiens)
IL18 [extracellular region] (Homo sapiens)
IL18:IL18R1 [plasma membrane] (Homo sapiens)
IL18 [extracellular region] (Homo sapiens)
IL18BP:IL18 [extracellular region] (Homo sapiens)
IL18 [extracellular region] (Homo sapiens)
IL18:IL18R1 binds IL18RAP (Homo sapiens)
IL18:IL18R1 [plasma membrane] (Homo sapiens)
IL18 [extracellular region] (Homo sapiens)
IL18:IL18R1:IL18RAP [plasma membrane] (Homo sapiens)
IL18:IL18R1 [plasma membrane] (Homo sapiens)
IL18 [extracellular region] (Homo sapiens)
IL18BP binds IL18 (Homo sapiens)
IL18 [extracellular region] (Homo sapiens)
IL18BP:IL18 [extracellular region] (Homo sapiens)
IL18 [extracellular region] (Homo sapiens)
Interleukin-10 signaling (Homo sapiens)
IL10 negatively regulates extracellular inflammatory mediators (Homo sapiens)
IL10-downregulated extracellular proteins [extracellular region] (Homo sapiens)
IL18 [extracellular region] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Regulated Necrosis (Homo sapiens)
Pyroptosis (Homo sapiens)
Interleukin-1 family are secreted (Homo sapiens)
Interleukin-1 family [extracellular region] (Homo sapiens)
IL18 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14116 IL18
Gene Names
IL18, IGIF, IL1F4
Chain
propeptide:1-36, chain:37-193
Reference Genes
BioGPS Gene:3606 IL18
COSMIC (genes):IL18 IL18
CTD Gene:3606 IL18
dbSNP Gene:3606 IL18
ENSEMBL:ENSG00000150782 IL18
ENSEMBL_homo_sapiens_GENE:ENSG00000150782.12 IL18
HGNC:5986 IL18
KEGG Gene (Homo sapiens):3606 IL18
Monarch:3606 IL18
NCBI Gene:3606 IL18
OMIM:600953 IL18
UCSC:Q14116 IL18
Reference Transcript
RefSeq:NM_001243211.1 IL18
RefSeq:NM_001562.3 IL18
RefSeq:XM_011542806.2 IL18
RefSeq:XM_011542805.1 IL18
Other Identifiers
1165_at
11727092_x_at
16744415
206295_3p_at
206295_PM_at
206295_at
3391256
3391257
3391258
3391266
3391267
3391268
3391274
3391275
3391277
3391278
3606
7951686
A_23_P104798
D49950_at
GE57234
GO:0001525
GO:0002376
GO:0005125
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006954
GO:0006955
GO:0007155
GO:0007267
GO:0008283
GO:0010468
GO:0010557
GO:0010628
GO:0010744
GO:0023052
GO:0030101
GO:0030154
GO:0030155
GO:0030431
GO:0032722
GO:0032725
GO:0032729
GO:0032736
GO:0032740
GO:0032819
GO:0034105
GO:0035655
GO:0036211
GO:0038061
GO:0042088
GO:0042092
GO:0042104
GO:0042119
GO:0042267
GO:0042531
GO:0042632
GO:0045515
GO:0045630
GO:0045662
GO:0045944
GO:0048018
GO:0048661
GO:0048856
GO:0050729
GO:0050830
GO:0051092
GO:0051142
GO:0051897
GO:0061436
GO:0070328
GO:0098542
GO:0098772
GO:0120162
GO:0150078
GO:1901224
GO:2000556
HMNXSV003036617
ILMN_1778457
TC11002293.hg
g4504652_3p_at
g4504652_3p_x_at
Participates
as a member of
IL10-downregulated extracellular proteins [extracellular region] (Homo sapiens)
Interleukin-1 family [extracellular region] (Homo sapiens)
as an input of
IL18BP binds IL18 (Homo sapiens)
IL18 binds IL18R1 (Homo sapiens)
as a component of
IL18BP:IL18 [extracellular region] (Homo sapiens)
IL18:IL18R1 [plasma membrane] (Homo sapiens)
Other forms of this molecule
IL18(1-36) [cytosol]
IL18 [cytosol]
IL18(1-193) [cytosol]
Inferred To
IL18 [extracellular region]
(Bos taurus)
IL18 [extracellular region]
(Canis familiaris)
IL18 [extracellular region]
(Sus scrofa)
Homologues of IL18 [extracellular region]
(Sus scrofa)
Homologues of IL18 [extracellular region]
(Xenopus tropicalis)
Il18 [extracellular region]
(Mus musculus)
Il18 [extracellular region]
(Rattus norvegicus)
LOC105946938 [extracellular region]
(Xenopus tropicalis)
il1b [extracellular region]
(Xenopus tropicalis)
IL-18 [extracellular region]
(Gallus gallus)
il-1FMA [extracellular region]
(Danio rerio)
Cross References
RefSeq
NP_001230140.1
,
NP_001553.1
,
XP_011541108.1
,
XP_011541107.1
OpenTargets
ENSG00000150782
GeneCards
Q14116
HPA
ENSG00000150782-IL18
Ensembl
ENST00000528832
,
ENSG00000150782
,
ENSP00000434161
,
ENST00000524595
,
ENSP00000434561
,
ENSP00000280357
,
ENST00000280357
PRO
Q14116
Pharos - Targets
Q14116
Orphanet
24619
PDB
4XFU
,
4R6U
,
1J0S
,
4EKX
,
4XFS
,
3WO3
,
3F62
,
4XFT
,
4EEE
,
2VXT
,
4HJJ
,
3WO2
,
3WO4
,
7AL7
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13478 IL18R1
1
IL18R1 [plasma membrane]
(R-HSA-197600)
0.558
2
UniProt:Q9IW12 Q9IW12
0.558
2
UniProt:Q15847 ADIRF
1
ADIRF [nucleoplasm]
(R-HSA-8936822)
0.556
3
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