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IL6ST [plasma membrane]
Stable Identifier
R-HSA-448453
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
IL6RB, Interleukin-6 receptor subunit beta, IL6RB_HUMAN, GP130
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-27 signaling (Homo sapiens)
IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Homo sapiens)
IL27:EBI3:IL27RA:p-JAK1:IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Homo sapiens)
IL6ST:(p-JAK1:p-JAK2:p-TYK2) [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
Interleukin-27 binds Interleukin-27 receptor (Homo sapiens)
IL27:EBI3:IL27RA:JAK1:IL6ST:JAK1,JAK2,(TYK2) [plasma membrane] (Homo sapiens)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
Interleukin-27 dissociates from Interleukin-27 receptor (Homo sapiens)
IL27:EBI3:IL27RA:JAK1:IL6ST:JAK1,JAK2,(TYK2) [plasma membrane] (Homo sapiens)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Homo sapiens)
IL27:EBI3:IL27RA:JAK1:IL6ST:JAK1,JAK2,(TYK2) [plasma membrane] (Homo sapiens)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
IL27:EBI3:IL27RA:p-JAK1:IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Homo sapiens)
IL6ST:(p-JAK1:p-JAK2:p-TYK2) [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
JAK1,JAK2,(TYK2) bind IL6ST (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
Interleukin-35 Signalling (Homo sapiens)
IL35 binds IL-12RB2:IL6ST receptor (Homo sapiens)
IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] (Homo sapiens)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
IL35 binds IL6ST:IL6ST receptor (Homo sapiens)
IL-35:(IL6ST:JAK1:JAK2) dimer [plasma membrane] (Homo sapiens)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT4 [plasma membrane] (Homo sapiens)
STAT1:IL12A:EBI3:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL6ST:p-JAK1 [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT4 [plasma membrane] (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL6ST:p-JAK1 [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Homo sapiens)
IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] (Homo sapiens)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL6ST:p-JAK1 [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Homo sapiens)
IL-35:(IL6ST:JAK1:JAK2) dimer [plasma membrane] (Homo sapiens)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
IL35:(IL6ST:p-JAK1:p-JAK2:p-TYK2) dimer [plasma membrane] (Homo sapiens)
IL6ST:p-JAK1:p-JAK2:p-TYK2 [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Homo sapiens)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer: STAT1 [plasma membrane] (Homo sapiens)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer:p-STAT1 [plasma membrane] (Homo sapiens)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL6ST:p-JAK1 [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT4 [plasma membrane] (Homo sapiens)
STAT1:IL12A:EBI3:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL6ST:p-JAK1 [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
STAT1 associates with IL6ST:IL6ST (Homo sapiens)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer: STAT1 [plasma membrane] (Homo sapiens)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL6ST:p-JAK1 [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT4 [plasma membrane] (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL6ST:p-JAK1 [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
p-STAT1 dissociates from IL6ST:IL6ST (Homo sapiens)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer:p-STAT1 [plasma membrane] (Homo sapiens)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
Interleukin-6 family signaling (Homo sapiens)
IL-6-type cytokine receptor ligand interactions (Homo sapiens)
IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Homo sapiens)
IL6RA:IL6:IL6RB:JAKs [plasma membrane] (Homo sapiens)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
LIFR:JAKs bind gp130:JAKs:CNTFR (Homo sapiens)
CNTF:CNTFR,CRLF1:CLCF1:CNTFR:IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Homo sapiens)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
CNTF:CNTFR,CRLF1:CLCF1:CNTFR:gp130:JAKs:LIFR:JAKs [plasma membrane] (Homo sapiens)
CNTF:CNTFR,CRLF1:CLCF1:CNTFR:IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Homo sapiens)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
OSM,LIF,CTF1 receptor complex binds gp130 (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
LIF,OSM receptor complex:gp130 [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
gp130:JAKs bind CNTFR (Homo sapiens)
CNTF:CNTFR,CRLF1:CLCF1:CNTFR:IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Homo sapiens)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
Interleukin-6 signaling (Homo sapiens)
Assembly of hexameric IL-6 receptor (Homo sapiens)
IL6 receptor hexamer:JAKs [plasma membrane] (Homo sapiens)
IL6 receptor trimer:JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:IL6RB:JAKs [plasma membrane] (Homo sapiens)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Homo sapiens)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
IL6 receptor trimer:JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:IL6RB:JAKs [plasma membrane] (Homo sapiens)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Homo sapiens)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Homo sapiens)
IL6:IL6RA:IL6RB:JAKs [plasma membrane] (Homo sapiens)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Homo sapiens)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Homo sapiens)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
IL6ST is tyrosine phosphorylated (Homo sapiens)
IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6 receptor trimer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
IL6:sIL6R:IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
JAK activation (Homo sapiens)
IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6 receptor trimer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
IL6:sIL6R:IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
IL6 receptor hexamer:JAKs [plasma membrane] (Homo sapiens)
IL6 receptor trimer:JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:IL6RB:JAKs [plasma membrane] (Homo sapiens)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Homo sapiens)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
JAK1,JAK2,(TYK2) bind IL6ST (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Homo sapiens)
IL6ST [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P40189 IL6ST
Gene Names
IL6ST
Chain
signal peptide:1-22, chain:23-918
Reference Genes
ENSEMBL:ENSG00000134352 IL6ST
Participates
as a component of
IL6ST:p-JAK1:p-JAK2:p-TYK2 [plasma membrane] (Homo sapiens)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Homo sapiens)
IL6ST:p-JAK1 [plasma membrane] (Homo sapiens)
IL6ST:(p-JAK1:p-JAK2:p-TYK2) [plasma membrane] (Homo sapiens)
LIF,OSM receptor complex:gp130 [plasma membrane] (Homo sapiens)
IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
Jaks:IL6RB [plasma membrane] (Homo sapiens)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Homo sapiens)
as an input of
OSM,LIF,CTF1 receptor complex binds gp130 (Homo sapiens)
Jaks associate with IL6RB (gp130) (Homo sapiens)
JAK1,JAK2,(TYK2) bind IL6ST (Homo sapiens)
Other forms of this molecule
p-Y-IL6ST [plasma membrane]
Inferred To
IL6ST [plasma membrane]
(Bos taurus)
IL6ST [plasma membrane]
(Canis familiaris)
IL6ST [plasma membrane]
(Sus scrofa)
gp130 [plasma membrane]
(Gallus gallus)
Il6st [plasma membrane]
(Mus musculus)
Il6st [plasma membrane]
(Rattus norvegicus)
il6st [plasma membrane]
(Danio rerio)
il6st [plasma membrane]
(Xenopus tropicalis)
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P26441 CNTF
1
CNTF [extracellular region]
(R-HSA-5696441)
0.691
10
UniProt:P13725 OSM
1
OSM [extracellular region]
(R-HSA-5696440)
0.688
4
UniProt:P05231 IL6
3
IL6 [extracellular region]
(R-HSA-447100)
IL6 [endoplasmic reticulum lumen]
(R-HSA-8956764)
p-IL6 [endoplasmic reticulum lumen]
(R-HSA-8957044)
0.667
3
UniProt:Q96EQ0 SGTB
0.666
4
UniProt:P42227 Stat3
13
phospho-Stat3 [nucleoplasm]
(R-MMU-1112554)
phospho-Stat3 [cytosol]
(R-MMU-914048)
Stat3 [cytosol]
(R-MMU-539044)
phospho-Stat3 [cytosol]
(R-MMU-8983130)
Stat3 [cytosol]
(R-MMU-914084)
p-Y705-Stat3 [cytosol]
(R-MMU-914034)
p(Y705)-Stat3 [nucleoplasm]
(R-MMU-2730582)
phospho-Stat3 [cytosol]
(R-MMU-539048)
phospho-Stat3 [nucleoplasm]
(R-MMU-9027589)
phospho-Stat3 [nucleoplasm]
(R-MMU-9701429)
phospho-Stat3 [nucleoplasm]
(R-MMU-9701435)
phospho-Stat3 [cytosol]
(R-MMU-8982823)
phospho-Stat3 [nucleoplasm]
(R-MMU-8983188)
0.656
4
UniProt:P15018 LIF
1
LIF [extracellular region]
(R-HSA-5696436)
0.623
2
UniProt:Q9Y2W7 KCNIP3
2
KCNIP3 [plasma membrane]
(R-HSA-5577044)
KCNIP3 [nucleoplasm]
(R-HSA-9640052)
0.601
7
UniProt:O43765 SGTA
1
SGTA [cytosol]
(R-HSA-5423595)
0.556
3
UniProt:P43364 MAGAB
0.556
3
UniProt:Q9NZI2-2 Q9NZI22-1
0.556
3
UniProt:Q2HRC7 VIL6
0.544
2
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