Reactome: A Curated Pathway Database

IL22 binds IL22RA1:JAK1 receptor complex

Stable Identifier
R-HSA-448480
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
IL22RA1 binds IL22
Locations in the PathwayBrowser
Summation

Temporal models suggest that the first event in IL22 receptor formation is binding of Interleukin-22 (IL22) to IL22RA1), which pre associates with JAK1 (Li et al. 2004, Jones et al. 2008, Xie et al. 2000, Xu et al. 2001).
The Interleukin-22 receptor consists of IL22RA1 and Interleukin-10 receptor subunit beta (IL10RB), which is also a component of the receptors for Interleukin-10 (IL10), Interleukin-22 (IL22), Interleukin-26 (IL26), Interleukin-28 (IL28), and Interferon lambda-1 (IFNL1).

Literature References
Participants
Participant Of
This entity is regulated by:
Orthologous Events