IL22 binds IL22RA1:JAK1 receptor complex

Stable Identifier
Homo sapiens
IL22RA1 binds IL22
Locations in the PathwayBrowser

Temporal models suggest that the first event in IL22 receptor formation is binding of Interleukin-22 (IL22) to IL22RA1), which pre associates with JAK1 (Li et al. 2004, Jones et al. 2008, Xie et al. 2000, Xu et al. 2001).
The Interleukin-22 receptor consists of IL22RA1 and Interleukin-10 receptor subunit beta (IL10RB), which is also a component of the receptors for Interleukin-10 (IL10), Interleukin-22 (IL22), Interleukin-26 (IL26), Interleukin-28 (IL28), and Interferon lambda-1 (IFNL1).

Literature References
PubMed ID Title Journal Year
11481447 A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist

Xu, W, Presnell, SR, Parrish-Novak, J, Kindsvogel, W, Jaspers, S, Chen, Z, Dillon, SR, Gao, Z, Gilbert, T, Madden, K, Schlutsmeyer, S, Yao, L, Whitmore, TE, Chandrasekher, Y, Grant, FJ, Maurer, M, Jelinek, L, Storey, H, Brender, T, Hammond, A, Topouzis, S, Clegg, CH, Foster, DC

Proc Natl Acad Sci U S A 2001
18599299 Structure of IL-22 bound to its high-affinity IL-22R1 chain

Jones, BC, Logsdon, NJ, Walter, MR

Structure 2008
10875937 Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R

Xie, MH, Aggarwal, S, Ho, WH, Foster, J, Zhang, Z, Stinson, J, Wood, WI, Goddard, AD, Gurney, AL

J Biol Chem 2000
15120653 Temporal associations between interleukin 22 and the extracellular domains of IL-22R and IL-10R2

Li, J, Tomkinson, KN, Tan, XY, Wu, P, Yan, G, Spaulding, V, Deng, B, Annis-Freeman, B, Heveron, K, Zollner, R, De Zutter, G, Wright, JF, Crawford, TK, Liu, W, Jacobs, KA, Wolfman, NM, Ling, V, Pittman, DD, Veldman, GM, Fouser, LA

Int. Immunopharmacol. 2004
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Orthologous Events