Reactome | CASP1(1-404) [cytosol]

CASP1(1-404) [cytosol]

Stable Identifier

R-HSA-448692

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Procaspase-1, CASP1 propeptide, Caspase-1 propeptide, CASP1, CASP1_HUMAN

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Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Caspase Activators and Caspases (Homo sapiens)
        
        TP53 family members stimulate CASP1 expression (Homo sapiens)
        
        CASP1(1-404) [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P29466 CASP1

Gene Names

CASP1, IL1BC, IL1BCE

Chain

propeptide:1-119, chain:120-297, propeptide:298-316, chain:317-404

Reference Genes

COSMIC (genes):CASP1 CASP1

dbSNP Gene:834 CASP1

ENSEMBL:ENSG00000137752 CASP1

Participates

as an output of

TP53 family members stimulate CASP1 expression (Homo sapiens)

as an input of

as a candidate of

Long prodomain caspases [cytosol] (Homo sapiens)

as a component of

Other forms of this molecule

CASP1(1-119) [cytosol]

CASP1(120-297) [cytosol]

CASP1(317-404) [cytosol]

CASP1(298-316) [cytosol]

Inferred To

CASP1 [cytosol] (Bos taurus)

CASP1 [cytosol] (Sus scrofa)

Casp1 [cytosol] (Mus musculus)

Casp1 [cytosol] (Rattus norvegicus)

casp1 [cytosol] (Xenopus tropicalis)

CASP4 [cytosol] (Canis familiaris)

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9ULZ3 PYCARD	4	PYCARD [cytosol] (R-HSA-561191) PYCARD [secretory granule lumen] (R-HSA-6800957) PYCARD [extracellular region] (R-HSA-6806196) PYCARD [azurophil granule lumen] (R-HSA-6798768)	0.861	11
UniProt:Q9NPP4 NLRC4	1	NLRC4 [cytosol] (R-HSA-561198)	0.743	4
UniProt:Q08AM6 VAC14	3	VAC14 [Golgi membrane] (R-HSA-1806235) VAC14 [early endosome membrane] (R-HSA-1806207) VAC14 [late endosome membrane] (R-HSA-1806219)	0.666	4
UniProt:Q9C000 NLRP1	1	NLRP1 [cytosol] (R-HSA-561196)	0.656	3
UniProt:P57730 CAR18			0.598	3
UniProt:Q5XLA6 CAR17			0.591	3
UniProt:P57764 GSDMD	13	GSDMD(1-275) [cytosol] (R-HSA-9647641) GSDMD [cytosol] (R-HSA-6801577) GSDMD(276-484) [cytosol] (R-HSA-9647672) S-(2-succinyl)-C191-GSDMD [cytosol] (R-HSA-9716198) GSDMD(269-484) [cytosol] (R-HSA-9710116) GSDMD(1-268) [cytosol] (R-HSA-9710104) dithiocarb-C191-GSDMD(1-275) [cytosol] (R-HSA-9693317) GSDMD(1-87) [cytosol] (R-HSA-9686099) GSDMD(88-484) [cytosol] (R-HSA-9686133) GSDMD [specific granule lumen] (R-HSA-6801468) GSDMD [extracellular region] (R-HSA-6801576) GSDMD [tertiary granule lumen] (R-HSA-6801501) GSDMD [ficolin-1-rich granule lumen] (R-HSA-6801498)	0.591	4
UniProt:Q9HC29 NOD2	1	NOD2 [cytosol] (R-HSA-168411)	0.591	4
UniProt:P29466 CASP1	5	CASP1(1-119) [cytosol] (R-HSA-448680) CASP1(120-297) [cytosol] (R-HSA-448686) CASP1(317-404) [cytosol] (R-HSA-448704) CASP1(298-316) [cytosol] (R-HSA-448674) CASP1(1-404) [cytosol] (R-HSA-448692)	0.587	2
UniProt:P58753-2 TIRAP			0.581	5
UniProt:P01583 IL1A	4	Myr82K-Myr83K-IL1A [extracellular region] (R-HSA-445746) IL1A(1-112) [cytosol] (R-HSA-449059) 2xMyri-IL1A [cytosol] (R-HSA-449054) IL1A(1-271) [cytosol] (R-HSA-449042)	0.524	3
UniProt:O14862 AIM2	1	AIM2 [cytosol] (R-HSA-874111)	0.488	2

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