Reactome: A Curated Pathway Database

IL24 binds to IL22RA1:JAK1:IL20RB

Stable Identifier
R-HSA-448708
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Synonyms
IL20, IL24 bind to IL22RA1:JAK1:IL20RB receptor complex, IL22RA:IL20RB is a receptor for IL20, IL24
Locations in the PathwayBrowser
Summation

Interleukin-24 (IL24) (and Interleukin-20 (IL20)) can activate a complex that consists of Interleukin-22 receptor subunit alpha-1 (IL22RA1), which is associated with Tyrosine-protein kinase JAK1 (JAK1) and Interleukin-20 receptor B (IL20RB) (Dumoutier et al. 2001, Parrish-Novak et al. 2002). As it is not clear whether the receptor can form in the absence of ligand, association of the ligand with the receptor trimer is represented here as an uncertain event.

Literature References
Participants
Participant Of
Orthologous Events