IL19 binds IL20RA:JAK1:IL20RB

Stable Identifier
R-HSA-448728
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Synonyms
IL20RA:IL20RB binds IL19
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Interleukin-19 (IL19) binds a heterodimeric receptor complex that consists of Interleukin-20 Receptor subunit alpha (IL20RA) associated with Tyrosine-protein kinase JAK1 (JAK1) and Interleukin-20 receptor subunit beta (IL20RB).
Interleukin-20 receptor A (IL20RA) and Interleukin-20 receptor B (IL20RB) form a receptor complex for Interleukin-19 (IL19) (and Interleukin-20 (IL20) and Interleukin-24 (IL24)) (Gallagher et al. 2000, Blumberg et al. 2001, Parrish-Novak et al. 2002, Logsdon et al. 2012, Rutz et al. 2014, Pletnev et al. 2003).
This is a black box event because it is not clear whether the dimeric receptor can form in the absence of ligand.

Literature References
PubMed ID Title Journal Year
14580208 Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20

Pletnev, S, Magracheva, E, Kozlov, S, Tobin, G, Kotenko, SV, Wlodawer, A, Zdanov, A

Biochemistry 2003
22802649 Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines

Logsdon, NJ, Deshpande, A, Harris, BD, Rajashankar, KR, Walter, MR

Proc. Natl. Acad. Sci. U.S.A. 2012
12351624 Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions

Parrish-Novak, J, Xu, W, Brender, T, Yao, L, Jones, C, West, J, Brandt, C, Jelinek, L, Madden, K, McKernan, PA, Foster, DC, Jaspers, S, Chandrasekher, YA

J Biol Chem 2002
11196675 Cloning, expression and initial characterization of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10)

Gallagher, G, Dickensheets, H, Eskdale, J, Izotova, LS, Mirochnitchenko, OV, Peat, JD, Vazquez, N, Pestka, S, Donnelly, RP, Kotenko, SV

Genes Immun. 2000
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