IL22RA2 binds IL22

Stable Identifier
R-HSA-448741
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Interleukin-22 receptor subunit alpha-2 (IL22RA2), also known as Interleukin-22 binding protein (IL22BP), is a soluble receptor that binds Interleukin-22 (IL22) within the extracellular region, preventing IL22 from binding to the functional membrane-associated IL22 receptor (Xu et al. 2001, De Moura et al. 2009, Dumoutier et al. 2001, Kotenko et al. 2001). This may play a regulatory role in inflammation.

Literature References
PubMed ID Title Journal Year
11390454 Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity

Kotenko, SV, Izotova, LS, Mirochnitchenko, OV, Esterova, E, Dickensheets, H, Donnelly, RP, Pestka, S

J Immunol 2001
11390453 Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22

Dumoutier, L, Lejeune, D, Colau, D, Renauld, JC

J Immunol 2001
Participants
Participant Of
Orthologous Events
Authored
Reviewed