Phosphorylation of E proteins by p38 MAPK

Stable Identifier
R-HSA-448948
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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p38 MAPK plays a fundamental role in the transition of myoblasts to different myocytes. Activated p38 MAPK phosphorylates E12/E47, a member of the E protein subfamily of bHLH proteins. p38 MAPK in particular phosphorylates Ser140 of E47. Its been observed that phosphorylation of E47 improves its ability to form heterodimers with Myod transcription factor.

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hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of phospho-p38 alpha/beta/gamma MAPK [nucleoplasm]
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Activity
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