Activation of p38 alpha/beta MAPK

Stable Identifier
R-HSA-448951
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
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p38 alpha/beta MAPK is well established as a promyogenic kinase, but the mechanism by which it is activated during differentiation is not well understood. CDO, JLP and p38 form a ternary complex and it is anticipated that in its role as a scaffold, JLP brings additional components of the pathway, such as MKKs, to these complexes and cooperate to activate p38 alpha/beta MAPK pathway. p38 is activated by phosphorylation on a canonical TxY motif by dual specificity kinases MKK6 and MKK3. MKK6 is the most abundant in skeletal muscles and displays minimal substrate selectivity among all p38 isoforms.

Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
MAP kinase kinase activity of p-S207,T211-MAP2K6 [cytosol]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created