Caspase-3 cleaves pro-interleukin-16

Stable Identifier
R-HSA-449073
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The mature and biologically active secreted interleukin-16 (IL16) is a 13-kDa carboxy terminal peptide derived from a larger intracellular precursor protein. Cleavage of IL16 from the propeptide is mediated by caspase-3. IL16 is a chemoattractant for a variety of cell types that express the cell surface antigen CD4.

Literature References
PubMed ID Title Journal Year
9422780 Processing and activation of pro-interleukin-16 by caspase-3 J Biol Chem 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activator activity involved in apoptotic process of Active Caspase-3 heterotetramer [cytosol]
Physical Entity
Activity
Orthologous Events