Interleukin-16 is secreted

Stable Identifier
R-HSA-449077
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Interleukin-16 (IL16) does not contain a consensus secretory leader sequence, and the mechanism for its release has not been elucidated. Amino-terminal deletions of IL16 reduce its capacity for secretion (Zhou et al. 1999), but the significance of this is unclear.

Literature References
PubMed ID Title Journal Year
10395686 Processing, secretion, and anti-HIV-1 activity of IL-16 with or without a signal peptide in CD4+ T cells

Zhou, P, Devadas, K, Tewari, D, Jegorow, A, Notkins, AL

J Immunol 1999
Participants
Participant Of
Orthologous Events
Authored
Reviewed