The Interleukin-15 (IL15) / Interleukin-15 receptor subunit alpha (IL15RA, IL15Rα) complex binds Interleukin-2 receptor subunit beta (IL2RB, IL2Rβ), which is associated with Tyrosine-protein kinase JAK1 (JAK1) and Cytokine receptor common subunit gamma (IL2RG, IL2Rγ), which is associated with Tyrosine-protein kinase JAK3 (JAK3) (Johnston et al. 1995). The heterodimer of IL2RB and IL2RG can bind IL15 with low affinity but high affinity binding requires a third component, IL15RA (Giri et al. 1994, 1995, Anderson et al. 1995). This is a Black Box Event because it is not clear whether the beta and gamma subunits pre-associate before binding IL15:IL15RA.
Anderson, DM, Kumaki, S, Ahdieh, M, Bertles, J, Tometsko, M, Loomis, A, Giri, J, Copeland, NG, Gilbert, DJ, Jenkins, NA
Giri, JG, Kumaki, S, Ahdieh, M, Friend, DJ, Loomis, A, Shanebeck, K, DuBose, R, Cosman, D, Park, LS, Anderson, DM
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