Reactome | IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3

IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3

Stable Identifier

R-HSA-449115

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane, cytosol

ReviewStatus

5/5

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IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3

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The Interleukin-15 (IL15) / Interleukin-15 receptor subunit alpha (IL15RA, IL15Rα) complex binds Interleukin-2 receptor subunit beta (IL2RB, IL2Rβ), which is associated with Tyrosine-protein kinase JAK1 (JAK1) and Cytokine receptor common subunit gamma (IL2RG, IL2Rγ), which is associated with Tyrosine-protein kinase JAK3 (JAK3) (Johnston et al. 1995). The heterodimer of IL2RB and IL2RG can bind IL15 with low affinity but high affinity binding requires a third component, IL15RA (Giri et al. 1994, 1995, Anderson et al. 1995). This is a Black Box Event because it is not clear whether the beta and gamma subunits pre-associate before binding IL15:IL15RA.

Literature References

PubMed ID	Title	Journal	Year
7641685	Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor Shanebeck, K, Anderson, DM, Ahdieh, M, Kumaki, S, Loomis, A, Park, LS, DuBose, R, Friend, DJ, Giri, JG, Cosman, D	EMBO J	1995
8530383	Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes Copeland, NG, Anderson, DM, Ahdieh, M, Kumaki, S, Jenkins, NA, Loomis, A, Tometsko, M, Bertles, J, Gilbert, DJ, Giri, J	J Biol Chem	1995