Reactome | TXLNA (IL14) binds syntaxin1A

TXLNA (IL14) binds syntaxin1A

Stable Identifier

R-HSA-449117

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Interleukin-14, renamed alpha-taxilin (TXLNA) was originally described as High molecular weight B-cell growth factor (Ambrus et al. 1994). TXLNA binds several forms of syntaxin (Nogami et al. 2003), but not when they are complexed with SNAP25, VAMP2 or STXBP1, suggesting that TXLNA interacts with syntaxins outside the SNARE complex. This observation and a predicted role in intracellular vesicle trafficking led to renaming of the gene. Txlna transgenic mice show a phenotype similar to systemic lupus erythematosus and Sjogren's syndrome (Shen et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
12558796	Taxilin; a novel syntaxin-binding protein that is involved in Ca2+-dependent exocytosis in neuroendocrine cells Nogami, S, Satoh, S, Nakano, M, Shimizu, H, Fukushima, H, Maruyama, A, Terano, A, Shirataki, H	Genes Cells	2003